Showing entry for C-C motif chemokine 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011876
Protein NameC-C motif chemokine 8
Uniport IdP80075
GeneCCL8
Gene Id6355
DomainIL8
Pfam PF00048  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0070098 chemokine-mediated signaling pathway
Biological Process GO:0006935 chemotaxis
Biological Process GO:0048245 eosinophil chemotaxis
Biological Process GO:0006887 exocytosis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0006954 inflammatory response
Biological Process GO:0031640 killing of cells of other organism
Biological Process GO:0048247 lymphocyte chemotaxis
Biological Process GO:0002548 monocyte chemotaxis
Biological Process GO:0044828 negative regulation by host of viral genome replication
Biological Process GO:0070664 negative regulation of leukocyte proliferation
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0002687 positive regulation of leukocyte migration
Biological Process GO:0009615 response to virus
Biological Process GO:0007165 signal transduction
molecular function GO:0048020 CCR chemokine receptor binding
molecular function GO:0008009 chemokine activity
molecular function GO:0008201 heparin binding
molecular function GO:0016004 phospholipase activator activity
molecular function GO:0004672 protein kinase activity
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002390 BXGD000110 Extrinsic allergic alveolitis Respiratory Tract Diseases; Immune System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002873 BXGD000133 Anemia of chronic disease Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020517 BXGD001415 Hypersensitivity Immune System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032300 BXGD002346 Lobar Pneumonia Infections; Respiratory Tract Diseases
C0035228 BXGD002515 Respiratory Hypersensitivity Respiratory Tract Diseases; Immune System Diseases
C0035328 BXGD002537 Retinal Vein Occlusion Eye Diseases; Cardiovascular Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0037268 BXGD002675 Skin Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0039104 BXGD002792 Synovitis and tenosynovitis Musculoskeletal Diseases
C0039520 BXGD002818 Tenosynovitis Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041326 BXGD002915 Pleural Tuberculosis Infections; Respiratory Tract Diseases
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085702 BXGD003247 Monocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0162820 BXGD003985 Dermatitis, Allergic Contact Skin and Connective Tissue Diseases; Immune System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0206019 BXGD004144 HIV Encephalopathy Infections; Immune System Diseases; Nervous System Diseases; Mental Disorders
C0206061 BXGD004147 Pneumonia, Interstitial Respiratory Tract Diseases
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0221232 BXGD004413 Welts Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0234245 BXGD004641 Visceral Pain Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0240419 BXGD005036 Muscle tenderness Musculoskeletal Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0276447 BXGD006425 Rhinovirus infection Infections
C0276548 BXGD006430 HIV encephalitis Infections; Immune System Diseases; Nervous System Diseases; Mental Disorders
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282548 BXGD006814 Leukostasis Hemic and Lymphatic Diseases
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0409952 BXGD008399 Idiopathic osteoarthritis Musculoskeletal Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0575064 BXGD009511 Skeletal muscle tender Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0578575 BXGD009550 Dissection of proximal aorta
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0750046 BXGD010225 Granulomatous uveitis Eye Diseases
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C0887898 BXGD011401 Experimental Lung Inflammation Infections; Respiratory Tract Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1275685 BXGD012092 Avellino corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384584 BXGD012943 Generalized osteoarthritis Musculoskeletal Diseases
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1609538 BXGD013444 Latent Tuberculosis Infections
C1619692 BXGD013458 Nephrogenic Fibrosing Dermopathy Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1845118 BXGD014713 SHORT STATURE, IDIOPATHIC, X-LINKED Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1860224 BXGD015967 ABLEPHARON-MACROSTOMIA SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Stomatognathic Diseases
C1959635 BXGD016646 Parvovirus B19 (disease)
C2827503 BXGD017799 HFE-Associated Hereditary Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3495919 BXGD019013 Enthesitis-Related Arthritis Musculoskeletal Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3811918 BXGD019664 GRN-related frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4024795 BXGD021422 Nongranulomatous uveitis Eye Diseases
C4554601 BXGD023566 Amyloidosis cutis dyschromia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003765 Psidiolic acid 129.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein