Showing entry for Metabotropic glutamate receptor 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013508
Protein NameMetabotropic glutamate receptor 4
Uniport IdQ14833
GeneGRM4
Gene Id2914
Domain7tm_3; ANF_receptor; NCD3G
Pfam PF00003   PF01094   PF07562  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007216 G protein-coupled glutamate receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0043523 regulation of neuron apoptotic process
Biological Process GO:0051966 regulation of synaptic transmission, glutamatergic
molecular function GO:0008066 glutamate receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0001642 group III metabotropic glutamate receptor activity
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0098793 presynapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007370 BXGD000462 Catalepsy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0014558 BXGD000933 Uncinate Epilepsy Nervous System Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026269 BXGD001897 Mitral Valve Stenosis Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0393672 BXGD008115 Epilepsy, Benign Psychomotor, Childhood Nervous System Diseases
C0393682 BXGD008117 Epilepsy, Lateral Temporal Nervous System Diseases
C0426980 BXGD008599 Motor symptoms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1839730 BXGD014396 Prieto X-linked mental retardation syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4281785 BXGD022415 Childhood Absence Epilepsy Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0023948 (S)-2-Aminoadipic Acid 161.07
BXGC0036441 Quisqualate 189.04
BXGC0036476 D-Glutamate 147.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein