Showing entry for MAP kinase-activated protein kinase 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018352
Protein NameMAP kinase-activated protein kinase 5
Uniport IdQ8IW41
GeneMAPKAPK5
Gene Id8550
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0032007 negative regulation of TOR signaling
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0051973 positive regulation of telomerase activity
Biological Process GO:1904355 positive regulation of telomere capping
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0006417 regulation of translation
Biological Process GO:0007165 signal transduction
Biological Process GO:0090400 stress-induced premature senescence
molecular function GO:0005524 ATP binding
molecular function GO:0009931 calcium-dependent protein serine/threonine kinase activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0004708 MAP kinase kinase activity
molecular function GO:0051019 mitogen-activated protein kinase binding
molecular function GO:0002039 p53 binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1277187 BXGD012109 Left ventricular systolic dysfunction Cardiovascular Diseases
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0002071 Apigenin 270.24
BXGC0005501 2'-Hydroxy-4,4',6'-trimethoxychalcone 314.33
BXGC0005683 Quercetin 302.24
BXGC0007014 Harman 182.22
BXGC0007029 Emodin 270.24
BXGC0012352 Chelerythrine 348.12
BXGC0024554 D-luciferin 280
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0034256 Rottlerin 516.18
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein