Showing entry for E3 ubiquitin-protein ligase TRIM63


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019610
Protein NameE3 ubiquitin-protein ligase TRIM63
Uniport IdQ969Q1
GeneTRIM63
Gene Id84676
Domainzf-B_box; zf-RING_UBOX
Pfam PF00643   PF13445  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006936 muscle contraction
Biological Process GO:0010614 negative regulation of cardiac muscle hypertrophy
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0070555 response to interleukin-1
Biological Process GO:0007165 signal transduction
Biological Process GO:0014732 skeletal muscle atrophy
molecular function GO:0031432 titin binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0031430 M band
cellular component GO:0005874 microtubule
cellular component GO:0005634 nucleus
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-9614085 FOXO-mediated transcription
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023269 BXGD001627 leiomyosarcoma Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026846 BXGD001939 Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029458 BXGD002158 Osteoporosis, Postmenopausal Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0031022 BXGD002268 Chronic periaortitis Pathological Conditions, Signs and Symptoms
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0035235 BXGD002519 Respiratory Syncytial Virus Infections Infections
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206657 BXGD004220 Alveolar Soft Part Sarcoma Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0264122 BXGD005366 Atrophy, Disuse Musculoskeletal Diseases; Nervous System Diseases
C0264716 BXGD005417 Chronic heart failure Cardiovascular Diseases
C0270948 BXGD006137 Neurogenic Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278607 BXGD006548 Adult Leiomyosarcoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279986 BXGD006705 Childhood Leiomyosarcoma Neoplasms
C0332949 BXGD006913 Overriding structures
C0333641 BXGD006961 Atrophic Pathological Conditions, Signs and Symptoms
C0334463 BXGD007076 Malignant Fibrous Histiocytoma Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0410158 BXGD008408 Muscle damage
C0429097 BXGD008648 QRS complex feature
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740380 BXGD009983 Varicella zoster
C0872084 BXGD011319 Sarcopenia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1279376 BXGD012119 Inflammatory abdominal aortic aneurysm Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1391732 BXGD012971 Cancer cachexia
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1842160 BXGD014501 MYOPATHY, MYOSIN STORAGE (disorder) Musculoskeletal Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931687 BXGD018048 Dysferlinopathy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4048297 BXGD021899 Idiopathic retroperitoneal fibrosis Pathological Conditions, Signs and Symptoms
C4087124 BXGD022132 Immunoglobulin G4-Related Disease Immune System Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein