Showing entry for Protocadherin-15


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019721
Protein NameProtocadherin-15
Uniport IdQ96QU1
GenePCDH15
Gene Id65217
DomainCadherin; ECD
Pfam PF00028   PF18432  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:0050957 equilibrioception
Biological Process GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Biological Process GO:0048839 inner ear development
Biological Process GO:0045494 photoreceptor cell maintenance
Biological Process GO:0050953 sensory perception of light stimulus
Biological Process GO:0007605 sensory perception of sound
molecular function GO:0005509 calcium ion binding
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0001750 photoreceptor outer segment
cellular component GO:0032420 stereocilium
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0009197 BXGD000592 Cochlear Diseases Otorhinolaryngologic Diseases
C0011052 BXGD000693 Prelingual Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0011053 BXGD000694 Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0013222 BXGD000805 Drug Use Disorders Chemically-Induced Disorders; Mental Disorders
C0015382 BXGD000980 Extraversion (Psychology) Behavior and Behavior Mechanisms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018979 BXGD001260 Hemianopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0029231 BXGD002125 Organic Mental Disorders, Substance-Induced Chemically-Induced Disorders; Mental Disorders
C0032000 BXGD002318 Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036454 BXGD002616 Scotoma Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0038580 BXGD002771 Substance Dependence Chemically-Induced Disorders; Mental Disorders
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0038663 BXGD002778 Suicide attempt Behavior and Behavior Mechanisms
C0086395 BXGD003277 Hearing Loss, Extreme Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0154860 BXGD003752 Hereditary retinal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0154920 BXGD003755 Pigmentary iris degeneration Eye Diseases; Skin and Connective Tissue Diseases
C0236969 BXGD004842 Substance-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0271097 BXGD006163 Usher Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0424574 BXGD008534 Duration of sleep
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0581883 BXGD009575 Complete Hearing Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0751068 BXGD010310 Deafness, Acquired Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1568247 BXGD013418 Usher Syndrome, Type I Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1568248 BXGD013419 Usher Syndrome, Type III Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1568249 BXGD013420 Usher Syndrome, Type II Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1832845 BXGD013878 USHER SYNDROME, TYPE ID Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1836027 BXGD014071 Deafness, Autosomal Recessive 23 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1842981 BXGD014547 NEUROTICISM Behavior and Behavior Mechanisms
C1843367 BXGD014576 Poor school performance
C1843865 BXGD014615 Vestibular dysfunction
C1848606 BXGD014950 Vestibular hypofunction
C1848638 BXGD014952 USHER SYNDROME, TYPE IB (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1848639 BXGD014953 USHER SYNDROME, TYPE IA, FORMERLY
C1848640 BXGD014954 USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY
C1854301 BXGD015391 Motor delay Mental Disorders
C1855925 BXGD015561 Hyperopia, High Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1865885 BXGD016352 Usher Syndrome, Type IF Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2732267 BXGD017551 Auditory neuropathy spectrum disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2931205 BXGD017977 Usher syndrome, type 1A Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2931208 BXGD017980 Usher syndrome, type 1D Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2931210 BXGD017981 Usher syndrome, type 1F Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C3276419 BXGD018690 USHER SYNDROME, TYPE ID/F, DIGENIC
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665473 BXGD019290 Bilateral Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021800 BXGD020790 Abnormality of dental enamel
C4023018 BXGD021068 Subcortical cerebral atrophy
C4025858 BXGD021832 Abnormal cochlea morphology
C4072872 BXGD022008 obsolete Rod-cone dystrophy
C4082305 BXGD022091 Deaf Mutism Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4316881 BXGD022709 Prescription Drug Abuse Chemically-Induced Disorders; Mental Disorders
C4551583 BXGD023361 Cerebral cortical atrophy
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein