Showing entry for Serine/threonine-protein kinase PLK3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020474
Protein NameSerine/threonine-protein kinase PLK3
Uniport IdQ9H4B4
GenePLK3
Gene Id1263
DomainPkinase; POLO_box
Pfam PF00069   PF00659  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
5. Organismal Systems 5.1 Immune system hsa04625 C-type lectin receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0031122 cytoplasmic microtubule organization
Biological Process GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Biological Process GO:0007113 endomitotic cell cycle
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0090166 Golgi disassembly
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0007093 mitotic cell cycle checkpoint
Biological Process GO:0044819 mitotic G1/S transition checkpoint
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1904716 positive regulation of chaperone-mediated autophagy
Biological Process GO:0090316 positive regulation of intracellular protein transport
Biological Process GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
Biological Process GO:0043491 protein kinase B signaling
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0051302 regulation of cell division
Biological Process GO:0032465 regulation of cytokinesis
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0006970 response to osmotic stress
Biological Process GO:0009314 response to radiation
Biological Process GO:0000302 response to reactive oxygen species
molecular function GO:0005524 ATP binding
molecular function GO:0002039 p53 binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0030425 dendrite
cellular component GO:0005795 Golgi stack
cellular component GO:0043025 neuronal cell body
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000922 spindle pole
Reactome
Pathway Id Pathway Name
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010633 BXGD000679 Cystadenoma Neoplasms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0018179 BXGD001177 Granular Dystrophy, Corneal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0034951 BXGD002498 Refractive Errors Eye Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0162534 BXGD003953 Prion Diseases Infections; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0240803 BXGD005055 Primary cerebral lymphoma Neoplasms; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0349534 BXGD007919 Carcinoma of anal margin Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1412036 BXGD013053 Anal squamous cell carcinoma Digestive System Diseases; Neoplasms
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363771 BXGD017104 Myopic astigmatism Eye Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3839737 BXGD019781 High astigmatism Eye Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004580 Carbanilide 212.25
BXGC0006647 Thymoquinone 164.2
BXGC0012352 Chelerythrine 348.12
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein