Showing entry for cGMP-dependent protein kinase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013409
Protein NamecGMP-dependent protein kinase 1
Uniport IdQ13976
GenePRKG1
Gene Id5592
DomaincNMP_binding; PKcGMP_CC; Pkinase
Pfam PF00027   PF16808   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0016358 dendrite development
Biological Process GO:0030900 forebrain development
Biological Process GO:0090331 negative regulation of platelet aggregation
Biological Process GO:1904753 negative regulation of vascular associated smooth muscle cell migration
Biological Process GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0001764 neuron migration
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0043087 regulation of GTPase activity
Biological Process GO:0060087 relaxation of vascular associated smooth muscle
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0005246 calcium channel regulator activity
molecular function GO:0030553 cGMP binding
molecular function GO:0004692 cGMP-dependent protein kinase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0004672 protein kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-195721 Signaling by WNT
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-4086398 Ca2+ pathway
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002103 BXGD000102 Atopic rhinitis Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C0003493 BXGD000199 Aortic Diseases Cardiovascular Diseases
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003706 BXGD000215 Arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0008074 BXGD000519 Child Development Disorders, Pervasive Mental Disorders
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013405 BXGD000834 Dyspnea, Paroxysmal Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Cardiovascular Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0019079 BXGD001278 Hemoptysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032326 BXGD002351 Pneumothorax Respiratory Tract Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036920 BXGD002645 Sezary Syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0038870 BXGD002782 Neuralgia, Supraorbital Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042656 BXGD002995 Neuralgia, Vidian Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042834 BXGD003004 Vital capacity
C0149630 BXGD003334 Bicuspid aortic valve Cardiovascular Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0162872 BXGD003997 Aortic Aneurysm, Thoracic Cardiovascular Diseases
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234119 BXGD004622 Neuromuscular inhibition
C0234247 BXGD004642 Neuralgia, Atypical Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234249 BXGD004643 Neuralgia, Stump Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0236733 BXGD004822 Amphetamine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236804 BXGD004835 Amphetamine Addiction Chemically-Induced Disorders; Mental Disorders
C0236807 BXGD004836 Amphetamine Abuse Chemically-Induced Disorders; Mental Disorders
C0241240 BXGD005089 Tall stature
C0241868 BXGD005118 acute aortic dissection Cardiovascular Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0263401 BXGD005298 Cutis marmorata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases; Cardiovascular Diseases; Wounds and Injuries
C0282313 BXGD006803 Condition, Preneoplastic Neoplasms
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0340647 BXGD007358 Distal aortic dissection
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0423711 BXGD008498 Neuralgia, Perineal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423712 BXGD008499 Neuralgia, Iliohypogastric Nerve Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0520572 BXGD009093 Enzymopathy Nutritional and Metabolic Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0546884 BXGD009345 Hypovolemia Pathological Conditions, Signs and Symptoms
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0751371 BXGD010415 Neuralgia, Ilioinguinal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751372 BXGD010416 Nerve Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751373 BXGD010417 Paroxysmal Nerve Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0871470 BXGD011316 Systolic Pressure
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1285654 BXGD012172 Memory performance
C1298820 BXGD012252 Aneurysm of aortic root Cardiovascular Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1388233 BXGD012961 Aneurysm of descending thoracic aorta Cardiovascular Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1836653 BXGD014143 Ascending aortic dissection Cardiovascular Diseases
C1837404 BXGD014229 High, narrow palate
C1849508 BXGD015060 EPILEPSY, PYRIDOXINE-DEPENDENT Nervous System Diseases
C1851712 BXGD015227 Dural ectasia
C1860493 BXGD015987 Abnormality of the sternum
C2825875 BXGD017779 Interferon Alpha Measurement
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3809513 BXGD019594 AORTIC ANEURYSM, FAMILIAL THORACIC 8
C4022878 BXGD021026 Descending aortic dissection Cardiovascular Diseases
C4025272 BXGD021615 Peripheral arterial stenosis
C4025690 BXGD021734 Prenatal maternal abnormality
C4025845 BXGD021825 Abnormality iris morphology
C4045968 BXGD021887 Altitude Hypoxia Respiratory Tract Diseases
C4049446 BXGD021933 Neointimal hyperplasia
C4476540 BXGD022824 Dilatation of the cerebral artery Nervous System Diseases; Cardiovascular Diseases
C4476554 BXGD022829 Carotid artery dilatation
C4509226 BXGD022972 Heart failure with preserved ejection fraction [HFpEF]
C4707243 BXGD023712 Familial thoracic aortic aneurysm and aortic dissection
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0002586 Calcium 40.08
BXGC0004266 2-Propanol 60.1
BXGC0012352 Chelerythrine 348.12
BXGC0028206 hexamethylene glycol 118.1
BXGC0036634 Cgmp 345.05
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein