Showing entry for Testosterone 17-beta-dehydrogenase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009956
Protein NameTestosterone 17-beta-dehydrogenase 3
Uniport IdP37058
GeneHSD17B3
Gene Id3293
Domainadh_short
Pfam PF00106  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006702 androgen biosynthetic process
Biological Process GO:0030539 male genitalia development
Biological Process GO:0006694 steroid biosynthetic process
Biological Process GO:0061370 testosterone biosynthetic process
molecular function GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-193048 Androgen biosynthesis
R-HSA-196071 Metabolism of steroid hormones
R-HSA-556833 Metabolism of lipids
R-HSA-75105 Fatty acyl-CoA biosynthesis
R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs
R-HSA-8957322 Metabolism of steroids
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001144 BXGD000028 Acne Vulgaris Skin and Connective Tissue Diseases
C0003810 BXGD000221 Sertoli-Leydig cell tumor of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0018418 BXGD001192 Gynecomastia Skin and Connective Tissue Diseases
C0019269 BXGD001310 Hermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021359 BXGD001498 Infertility Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033804 BXGD002426 Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0036875 BXGD002640 Disorders of Sex Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0156394 BXGD003856 Hypertrophy of clitoris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0238395 BXGD004922 Male Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0268296 BXGD005888 17-Hydroxysteroid Dehydrogenase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Endocrine System Diseases
C0268297 BXGD005889 Pseudovaginal Perineoscrotal Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0271623 BXGD006222 Hypogonadotropic hypogonadism Endocrine System Diseases
C0342471 BXGD007484 3 beta-Hydroxysteroid dehydrogenase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0432470 BXGD008792 46, XY female Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0520463 BXGD009085 Chronic active hepatitis Digestive System Diseases
C0555232 BXGD009435 pseudohermaphrodite (non-specific)
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0686346 BXGD009831 Gender Dysphoria Mental Disorders
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0936016 BXGD011475 Testicular Feminization Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1291316 BXGD012210 Deficiency of reductase
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1691215 BXGD013491 Penile hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C2751824 BXGD017742 46, XY Disorders of Sex Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2930618 BXGD017889 Intersex Conditions Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2930619 BXGD017890 Sex Differentiation Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C3160891 BXGD018492 Hormone-dependent prostate cancer Neoplasms; Male Urogenital Diseases
C3669122 BXGD019324 5-Alpha Reductase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4021985 BXGD020857 Germ cell neoplasia
C4025826 BXGD021813 Abnormality of the urethra
C4551492 BXGD023317 Micropenis
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000332 Fisetin 286.24
BXGC0002071 Apigenin 270.24
BXGC0004707 4'-Hydroxyacetophenone 136.15
BXGC0005624 Genistein 270.24
BXGC0005793 Baicalein 270.24
BXGC0005919 Biochanin A 284.27
BXGC0006306 Myricetin 318.24
BXGC0008784 p-Hydroxynonanophenone 234.33
BXGC0013582 Curcumin 368.13
BXGC0017757 Androstenedione 286.19
BXGC0024810 curcumin 368.13
BXGC0030094 Paroxypropione 150.07
BXGC0033999 Zuclomiphene 405.19
BXGC0047169 Hymecromone 176.05
BXGC0047871 7-Hydroxyflavone 238.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein