Showing entry for Physostigmine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0030685
Compound NamePhysostigmine
Structure
FormulaC15H21N3O2
InchiKeyPIJVFDBKTWXHHD-HIFRSBDPSA-N
SMILESCN=C(Oc1ccc2c(c1)[C@]1(C)CCN([C@@H]1N2C)C)O
InchiInChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
IUPAC[(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate
Molecular Weight275.16
Pubchem Id5983
Chembl IdCHEMBL94
Targets of Information Source
DrugBank DB00981
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE approved; investigational inhibitor
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 reviewed Ion channel CHRNA4 approved; investigational -
P17787 BXGT008341 Neuronal acetylcholine receptor subunit beta-2 reviewed Ion channel CHRNB2 approved; investigational -
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 11023
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 28 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 16 - -
reviewed BXGT006524 Genome polyprotein reviewed - - >50000000 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 40 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 850 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 40 - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 850 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 40 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 1 - -
reviewed BXGT008694 Acetylcholinesterase reviewed Ache - 0.69 - -
reviewed BXGT007641 Muscarinic acetylcholine receptor M2 reviewed Chrm2 - 160000 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 35 - -
reviewed BXGT007831 Muscarinic acetylcholine receptor M1 reviewed Chrm1 - 37000 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 43 - -
reviewed BXGT008908 Acetylcholinesterase reviewed ACHE - 123 - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 46 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 46 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 0.43 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 26000 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 25000 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 53000 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 35 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 129 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 28 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 31 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 22000 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 15 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 4000 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 61 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 19 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 73 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 80 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 14 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 23 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 128 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 190 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 930 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 7.7 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 60 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 210 - - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 11 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 14 - -
reviewed BXGT008908 Acetylcholinesterase reviewed ACHE - 146 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 47 - -
reviewed BXGT012706 Cholinesterase reviewed Bche - 280 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 857 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 41 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 857 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 30 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 1200 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 500 - -
reviewed BXGT005373 Bile salt export pump reviewed Transporter ABCB11 - >1000000 - -
reviewed BXGT005057 Bile salt export pump reviewed Abcb11 - >1000000 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 40 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 850 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 28 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 103 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 275 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 61 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 0.68 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 32 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 78 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 27.9 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 16 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 220 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 80 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 1500 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 160 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 580 - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 21.3 - -
reviewed BXGT008694 Acetylcholinesterase reviewed Ache - 40 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 1 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 56.7 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 1000 - - -
reviewed BXGT006430 Cholinesterase reviewed BCHE 5000 - - -
reviewed BXGT008908 Acetylcholinesterase reviewed ACHE - 30 - -
reviewed BXGT020312 Muscarinic acetylcholine receptor M2 reviewed Chrm2 - 160000 - -
reviewed BXGT008694 Acetylcholinesterase reviewed Ache - 0.68 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 5.7 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 28 - -
reviewed BXGT008908 Acetylcholinesterase reviewed ACHE - 63300 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 19 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 53 - -
reviewed BXGT008908 Acetylcholinesterase reviewed ACHE - 2580 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 1340 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 150 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 11 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 34 - - -
reviewed BXGT011959 Cholinesterase reviewed BCHE 41 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 90 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 42 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 18.97 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 57.02 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 23 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 18 - -
CHEMBL CHEMBL94
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 16 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 19 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 26 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 12589 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 43 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 18 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 23000 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 4 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 14 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 15811 nM
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 16 nM
Q9ERZ4 BXGT020312 Muscarinic acetylcholine receptor M2 reviewed - Chrm2 IC50 '=' 160000 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P12657 BXGT007831 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 IC50 '=' 37000 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 8 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache MIC '=' 0 ug
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 94 %
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 12995 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 1164 nM
P23795 BXGT008908 Acetylcholinesterase reviewed - ACHE IC50 '=' 146 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 14 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 2 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 pA2 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 34 nM
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
Q9JKC1 BXGT020830 Carboxylic ester hydrolase unreviewed - Bche IC50 '=' 7 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE MIC '=' 3 10'-4nmol
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9441 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 28 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 7 %
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 57 nM
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 3700 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ratio '=' 1 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ratio '=' 1 -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 0 ug.mL-1
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 190 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 30 %
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 13371 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 1340 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Kc '=' 0 M
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 17 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ratio '=' 11 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ratio '=' 11 -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 35 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 35 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 28183 nM
Q03311 BXGT012706 Cholinesterase reviewed - Bche IC50 '=' 280 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 281 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 41 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 25000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 53000 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 1200 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 850 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache Activity - - -
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 39810 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 18 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache ID50 '>' 1 mg.kg-1
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ratio IC50 '=' 2 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ratio IC50 '=' 2 -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 89 %
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
O00519 BXGT003934 Fatty-acid amide hydrolase 1 reviewed - FAAH Inhibition '=' 12 %
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache INH '=' 0 ug
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 87 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition - - -
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 73 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 0 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ratio '=' 0 -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ratio pIC50 '=' 2 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ratio pIC50 '=' 2 -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 57 nM
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 pKb - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P21836 BXGT008694 Acetylcholinesterase reviewed - Ache IC50 '=' 40 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 28 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 pA2 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE K '=' 41 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 129 nM
P23795 BXGT008908 Acetylcholinesterase reviewed - ACHE IC50 '=' 30 nM
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 1000 nM
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Ki '=' 41 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 46 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 47 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 23 nM
Q9JKC1 BXGT020830 Carboxylic ester hydrolase unreviewed - Bche IC50 '=' 23 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 90 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 493 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 13 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 27 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Selectivity '=' 1 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Selectivity '=' 1 -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
Q9JKC1 BXGT020830 Carboxylic ester hydrolase unreviewed - Bche IC50 '=' 8 nM
Q64133 BXGT016109 Amine oxidase [flavin-containing] A reviewed - Maoa Activity - - -
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 25118 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 103 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE logIC50 '=' 1 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Activity '=' 0 uM
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition - - -
P04058 BXGT006139 Acetylcholinesterase reviewed - ache IC50 '=' 46 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 22 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 275 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 4000 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 80 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE K '=' 0 /hr
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Inhibition '=' 92 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1458 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 19952 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 31 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 1 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE Ki - - -
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 1 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 56 nM
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache ID50 '=' 0 mg.kg-1
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 1500 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 30 nM
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 73 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 160 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 4666 nM
O00519 BXGT003934 Fatty-acid amide hydrolase 1 reviewed - FAAH Inhibition '=' 18 %
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P23795 BXGT008908 Acetylcholinesterase reviewed - ACHE IC50 '=' 123 nM
Q8VH26 BXGT018927 Muscarinic acetylcholine receptor unreviewed - GPM3 pA2 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 128 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 19 nM
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P21836 BXGT008694 Acetylcholinesterase reviewed - Ache IC50 '=' 0 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 40 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 7 nM
Q9JKC1 BXGT020830 Carboxylic ester hydrolase unreviewed - Bche Ratio '=' 11 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE k3 '=' 70000 min-1 M-1
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 14000 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 29934 nM
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 0 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '=' 200 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ratio '=' 0 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ratio '=' 0 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ki '=' 5000 nM
P10980 BXGT007641 Muscarinic acetylcholine receptor M2 reviewed - Chrm2 IC50 '=' 160000 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 857 nM
P21836 BXGT008694 Acetylcholinesterase reviewed - Ache IC50 '=' 0 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 18105 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 175 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 61 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 28 nM
P04058 BXGT006139 Acetylcholinesterase reviewed - ache IC50 '=' 11 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 61 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 60 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 580 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 7 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache K '=' 34 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 25099 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 22000 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 220 nM
P38571 BXGT010054 Lysosomal acid lipase/cholesteryl ester hydrolase reviewed Enzyme LIPA Inhibition - - -
Q9ERZ4 BXGT020312 Muscarinic acetylcholine receptor M2 reviewed - Chrm2 Ratio '=' 4 -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 4 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ratio '=' 3 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ratio '=' 3 -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 78 %
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE K '=' 280 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE k3 '=' 9 min-1
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache Inhibition - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 40 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE Inhibition '=' 82 %
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 930 nM
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 160 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 39810 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 42 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Activity '=' 3 10'-4nmol
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 44668 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 91 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 37933 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache K '=' 0 /min
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 26000 nM
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 11 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 80 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE K '=' 0 /min
P23795 BXGT008908 Acetylcholinesterase reviewed - ACHE IC50 '=' 2580 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 857 nM
Q9JKC1 BXGT020830 Carboxylic ester hydrolase unreviewed - Bche Inhibition - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 1000000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 0 ug.mL-1
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 32 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 78 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 14125 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 0 ug.mL-1
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 68589 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 220 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 2 nM
O70127 BXGT005057 Bile salt export pump reviewed - Abcb11 IC50 '>' 1000000 nM
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 150 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 31622 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 53 nM
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE K '=' 41 nM
P10980 BXGT007641 Muscarinic acetylcholine receptor M2 reviewed - Chrm2 Ratio '=' 4 -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Relative potency '=' 100 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 40 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 500 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 80 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 92 %
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 15 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE K '=' 0 /min
Q9JKC1 BXGT020830 Carboxylic ester hydrolase unreviewed - Bche IC50 '=' 58 nM
P36196 BXGT009910 Acetylcholinesterase reviewed - ACHE IC50 '=' 20 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 87 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 14 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Ratio '=' 0 /uM/min
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 91 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 850 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 82 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF03547 Physostigma venenosum Physostigma venenosum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease