Showing entry for Metabotropic glutamate receptor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013332
Protein NameMetabotropic glutamate receptor 1
Uniport IdQ13255
GeneGRM1
Gene Id2911
Domain7tm_3; ANF_receptor; GluR_Homer-bdg; NCD3G
Pfam PF00003   PF01094   PF10606   PF07562  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0000186 activation of MAPKK activity
Biological Process GO:0071257 cellular response to electrical stimulus
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007216 G protein-coupled glutamate receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Biological Process GO:0051930 regulation of sensory perception of pain
Biological Process GO:0051966 regulation of synaptic transmission, glutamatergic
Biological Process GO:0019233 sensory perception of pain
molecular function GO:0008066 glutamate receptor activity
molecular function GO:0098872 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
molecular function GO:0042802 identical protein binding
molecular function GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
cellular component GO:0030425 dendrite
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0038037 G protein-coupled receptor dimeric complex
cellular component GO:0038038 G protein-coupled receptor homodimeric complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0098839 postsynaptic density membrane
cellular component GO:0098685 Schaffer collateral - CA1 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-500792 GPCR ligand binding
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-6794362 Protein-protein interactions at synapses
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004138 BXGD000258 Ataxias, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007760 BXGD000476 Cerebellar Diseases Nervous System Diseases
C0008476 BXGD000543 Chondromatosis, Synovial Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0014558 BXGD000933 Uncinate Epilepsy Nervous System Diseases
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016045 BXGD001037 fibroma Neoplasms
C0016048 BXGD001038 Fibromatosis Neoplasms
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018552 BXGD001202 Hamartoma Neoplasms
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029427 BXGD002144 Synovial osteochondromatosis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0038661 BXGD002777 Suicide Behavior and Behavior Mechanisms
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041671 BXGD002930 Attention Deficit Disorder Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0152244 BXGD003571 Bone Cysts, Aneurysmal Neoplasms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205766 BXGD004118 Myxofibroma Neoplasms
C0206639 BXGD004204 Neoplasms, Bone Tissue Neoplasms
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0221290 BXGD004439 Chondromyxoid fibroma Neoplasms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234162 BXGD004627 Cerebellar Dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234979 BXGD004707 Dysdiadochokinesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236018 BXGD004804 Aura Nervous System Diseases
C0241237 BXGD005088 Difficulty standing Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0262404 BXGD005236 Cerebellar degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270823 BXGD006112 Petit mal status Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270972 BXGD006147 Cornelia De Lange Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0271385 BXGD006193 Horizontal Nystagmus Eye Diseases; Nervous System Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279530 BXGD006628 Malignant Bone Neoplasm Neoplasms; Musculoskeletal Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0311335 BXGD006877 Grand Mal Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0393672 BXGD008115 Epilepsy, Benign Psychomotor, Childhood Nervous System Diseases
C0393682 BXGD008117 Epilepsy, Lateral Temporal Nervous System Diseases
C0393734 BXGD008131 Complex Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423082 BXGD008468 Hypometric saccades
C0423083 BXGD008469 Hypermetric saccades
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0426980 BXGD008599 Motor symptoms
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0455829 BXGD008859 Waist Circumference
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684337 BXGD009796 Ewings sarcoma-primitive neuroectodermal tumor (PNET) Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0742034 BXGD010052 cerebellar function
C0751111 BXGD010319 Awakening Epilepsy Nervous System Diseases
C0751522 BXGD010488 Status Epilepticus, Subclinical Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751523 BXGD010489 Non-Convulsive Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751524 BXGD010490 Simple Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752120 BXGD010668 Spinocerebellar Ataxia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752122 BXGD010670 Spinocerebellar Ataxia Type 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752124 BXGD010672 Spinocerebellar Ataxia Type 6 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0852975 BXGD010959 Congenital cerebellar ataxia
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1321905 BXGD012450 Minimal Brain Dysfunction Mental Disorders
C1332347 BXGD012527 Atypical Ductal Breast Hyperplasia Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510420 BXGD013158 Cavitation
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1608408 BXGD013434 Malignant transformation
C1845370 BXGD014744 Retrocerebellar cyst
C1853394 BXGD015333 Gaze-evoked horizontal nystagmus Eye Diseases; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1854489 BXGD015408 Limb dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854494 BXGD015409 Slow progression
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1855350 BXGD015491 Inferior vermis hypoplasia
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
C3179455 BXGD018552 Niemann-Pick Disease, Type C1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3553816 BXGD019192 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 13
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4023405 BXGD021180 Abnormality of ocular abduction
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4521563 BXGD023061 SPINOCEREBELLAR ATAXIA 44
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0006162 L-Glutamic acid 147.13
BXGC0006186 L-Aspartic acid 133.1
BXGC0006187 2-Aminoheptanedioic acid 175.18
BXGC0023948 (S)-2-Aminoadipic Acid 161.07
BXGC0029437 (1R,2S)-2-[(S)-Amino(Carboxy)Methyl]Cyclopropane-1-Carboxylic Acid 159.05
BXGC0036441 Quisqualate 189.04
BXGC0036476 D-Glutamate 147.05
BXGC0038154 D-Aspartate 133.04
BXGC0039032 Glutamic Acid 145.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein