Showing entry for Glutamate receptor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010293
Protein NameGlutamate receptor 1
Uniport IdP42261
GeneGRIA1
Gene Id2890
DomainANF_receptor; Lig_chan; Lig_chan-Glu_bd
Pfam PF01094   PF00060   PF10613  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
6. Human Diseases 6.4 Neurodegenerative diseases hsa05014 Amyotrophic lateral sclerosis (ALS)
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0048208 COPII vesicle coating
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0007616 long-term memory
Biological Process GO:0060292 long-term synaptic depression
Biological Process GO:0031623 receptor internalization
Biological Process GO:2000310 regulation of NMDA receptor activity
Biological Process GO:0007165 signal transduction
molecular function GO:0004971 AMPA glutamate receptor activity
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0008066 glutamate receptor activity
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
molecular function GO:0030165 PDZ domain binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0032281 AMPA glutamate receptor complex
cellular component GO:0044308 axonal spine
cellular component GO:0009986 cell surface
cellular component GO:0030425 dendrite
cellular component GO:0043197 dendritic spine
cellular component GO:0032591 dendritic spine membrane
cellular component GO:0031901 early endosome membrane
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0012507 ER to Golgi transport vesicle membrane
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0000139 Golgi membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0044309 neuron spine
cellular component GO:0099544 perisynaptic space
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0098839 postsynaptic density membrane
cellular component GO:0055037 recycling endosome
cellular component GO:0055038 recycling endosome membrane
cellular component GO:0097060 synaptic membrane
cellular component GO:0030672 synaptic vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-392499 Metabolism of proteins
R-HSA-399710 Activation of AMPA receptors
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-438064 Post NMDA receptor activation events
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5694530 Cargo concentration in the ER
R-HSA-597592 Post-translational protein modification
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-8849932 Synaptic adhesion-like molecules
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9620244 Long-term potentiation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011253 BXGD000706 Delusions Behavior and Behavior Mechanisms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016722 BXGD001075 Frigidity Mental Disorders
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020594 BXGD001437 Hypoactive Sexual Desire Disorder Mental Disorders
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023186 BXGD001613 Learning Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0026552 BXGD001906 Morphine Dependence Chemically-Induced Disorders; Mental Disorders
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0029261 BXGD002126 Orgasmic Disorder Mental Disorders
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030201 BXGD002194 Pain, Postoperative Pathological Conditions, Signs and Symptoms
C0033953 BXGD002445 Psychosexual Disorders Mental Disorders
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036337 BXGD002598 Schizoaffective Disorder Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036902 BXGD002641 Sexual Arousal Disorder Mental Disorders
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0038587 BXGD002773 Substance Withdrawal Syndrome Chemically-Induced Disorders; Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0086189 BXGD003268 Drug Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0154723 BXGD003737 Migraine with Aura Nervous System Diseases
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0206725 BXGD004270 Subependymal Glioma Neoplasms
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0233488 BXGD004583 Feeling despair Behavior and Behavior Mechanisms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234245 BXGD004641 Visceral Pain Pathological Conditions, Signs and Symptoms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0266574 BXGD005697 Ablepharon Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280483 BXGD006750 Adult Anaplastic Astrocytoma Neoplasms
C0334579 BXGD007120 Anaplastic astrocytoma Neoplasms
C0338480 BXGD007186 Common Migraine Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0338831 BXGD007216 Manic Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0348165 BXGD007868 Central Nervous System Viral Diseases Infections; Nervous System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0376338 BXGD007990 Diagnosis, Psychiatric Mental Disorders
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432215 BXGD008739 Progressive pseudorheumatoid dysplasia Musculoskeletal Diseases
C0443306 BXGD008817 Spastic Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0524662 BXGD009238 Opiate Addiction Chemically-Induced Disorders; Mental Disorders
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0549622 BXGD009392 Sexual Dysfunction Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Mental Disorders; Behavior and Behavior Mechanisms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0600272 BXGD009702 Morphine Abuse Chemically-Induced Disorders; Mental Disorders
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0742078 BXGD010055 Mass lesion of brain
C0746408 BXGD010142 mass lesion
C0751217 BXGD010356 Hyperkinesia, Generalized Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751262 BXGD010368 Adult Learning Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751263 BXGD010369 Learning Disturbance Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0809983 BXGD010840 Schizophrenia and related disorders Mental Disorders
C0917796 BXGD011408 Optic Atrophy, Hereditary, Leber Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1266025 BXGD011935 Traditional Serrated Adenoma Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1330966 BXGD012478 Developmental Academic Disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1504404 BXGD013141 Hippocampal sclerosis
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1717947 BXGD013649 Incisional pain
C1720824 BXGD013686 Sudden Cardiac Arrest Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1960870 BXGD016669 Transformed migraine Nervous System Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887506 BXGD019886 Hyperkinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551548 BXGD023342 Grade III Childhood Astrocytoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0006162 L-Glutamic acid 147.13
BXGC0025199 (S)-Willardiine 199.06
BXGC0036476 D-Glutamate 147.05
BXGC0049516 Kainic Acid 213.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein