acompound

Showing entry for 7-Hydroxyflavone

General Compound Information
BXGC Id	BXGC0047871
Compound Name	7-Hydroxyflavone
Structure
Formula	C15H10O3
InchiKey	MQGPSCMMNJKMHQ-UHFFFAOYSA-N
SMILES	Oc1ccc2c(c1)oc(cc2=O)c1ccccc1
Inchi	InChI=1S/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H
IUPAC	7-hydroxy-2-phenylchromen-4-one
Molecular Weight	238.06
Pubchem Id	5281894
Chembl Id	CHEMBL276915

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

26664

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT007685	Serine/threonine-protein kinase pim-1	reviewed	Kinase	PIM1	-	14000	-	-
reviewed	BXGT009956	Testosterone 17-beta-dehydrogenase 3	reviewed		HSD17B3	-	9000	-	-
reviewed	BXGT007717	Aromatase	reviewed	Enzyme	CYP19A1	-	17200	-	-
reviewed	BXGT007685	Serine/threonine-protein kinase pim-1	reviewed	Kinase	PIM1	-	14125	-	-
reviewed	BXGT009437	Adenosine receptor A2a	reviewed		Adora2a	2692	-	-	-
reviewed	BXGT009016	Adenosine receptor A1	reviewed		Adora1	3020	-	-	-
reviewed	BXGT008197	Aldo-keto reductase family 1 member B1	reviewed		AKR1B1	-	45210	-	-
reviewed	BXGT009437	Adenosine receptor A2a	reviewed		Adora2a	2680	-	-	-
reviewed	BXGT009016	Adenosine receptor A1	reviewed		Adora1	3030	-	-	-
reviewed	BXGT004148	Arachidonate 15-lipoxygenase B	reviewed	Enzyme	ALOX15B	-	>100000	-	-
reviewed	BXGT006427	Tyrosine-protein kinase Lck	reviewed	Kinase	LCK	-	8	-	-
reviewed	BXGT009956	Testosterone 17-beta-dehydrogenase 3	reviewed		HSD17B3	-	66980	-	-
reviewed	BXGT008184	Arachidonate 15-lipoxygenase	reviewed	Enzyme	ALOX15	-	>100000	-	-
reviewed	BXGT008370	Arachidonate 12-lipoxygenase, 12S-type	reviewed	Enzyme	ALOX12	-	>100000	-	-
reviewed	BXGT007520	Calmodulin-1	reviewed		CALM1	-	37100	-	-
reviewed	BXGT024595	Calmodulin-3	reviewed		CALM3	-	37100	-	-
reviewed	BXGT007521	Calmodulin-2	reviewed		CALM2	-	37100	-	-
reviewed	BXGT008197	Aldo-keto reductase family 1 member B1	reviewed		AKR1B1	-	14650	-	-
reviewed	BXGT010602	Xanthine dehydrogenase/oxidase	reviewed	Enzyme	XDH	-	38000	-	-
reviewed	BXGT007979	Estradiol 17-beta-dehydrogenase 1	reviewed	Enzyme	HSD17B1	-	5250	-	-
reviewed	BXGT009957	Estradiol 17-beta-dehydrogenase 2	reviewed	Enzyme	HSD17B2	-	>20000	-	-
reviewed	BXGT007717	Aromatase	reviewed	Enzyme	CYP19A1	-	30.5	-	-
reviewed	BXGT005689	Carbonic anhydrase 1	reviewed		CA1	3370	-	-	-
reviewed	BXGT005689	Carbonic anhydrase 1	reviewed		CA1	3430	-	-	-
reviewed	BXGT005690	Carbonic anhydrase 2	reviewed		CA2	2240	-	-	-
reviewed	BXGT005690	Carbonic anhydrase 2	reviewed		CA2	2320	-	-	-
reviewed	BXGT013670	Carbonic anhydrase 9	reviewed		CA9	4920	-	-	-
reviewed	BXGT013670	Carbonic anhydrase 9	reviewed		CA9	4850	-	-	-
reviewed	BXGT004601	Carbonic anhydrase 12	reviewed		CA12	8400	-	-	-
reviewed	BXGT004601	Carbonic anhydrase 12	reviewed		CA12	8510	-	-	-
reviewed	BXGT008096	Androgen receptor	reviewed		Ar	-	>42657.95	-	-
reviewed	BXGT006741	ATP-dependent translocase ABCB1	reviewed	Transporter	ABCB1	-	-	34674	-
reviewed	BXGT011959	Cholinesterase	reviewed		BCHE	-	>100000	-	-
reviewed	BXGT004559	Acetylcholinesterase	reviewed		ache	-	85000	-	-

CHEMBL

CHEMBL276915

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q05769	BXGT012834	Prostaglandin G/H synthase 2	reviewed	-	Ptgs2	Inhibition	'='	70	%
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	Ki	'='	4200	nM
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	Ki	'='	4200	nM
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	Ki	'='	4200	nM
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	Ki	'='	4200	nM
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	Ki	'='	4200	nM
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	Ki	'='	4200	nM
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	Ki	'='	4200	nM
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	Ki	'='	4200	nM
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	Ki	'='	4200	nM
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	Ki	'='	4200	nM
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	Ki	'='	4200	nM
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	Ki	'='	4200	nM
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	Ki	'='	4200	nM
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	Ki	'='	4200	nM
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	Ki	'='	4200	nM
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	Ki	'='	4200	nM
P30543	BXGT009437	Adenosine receptor A2a	reviewed	-	Adora2a	Ki	'='	2680	nM
P11511	BXGT007717	Aromatase	reviewed	Enzyme	CYP19A1	IC50	'='	30	nM
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	reviewed	Enzyme	AKR1B10	Inhibition	'='	19	%
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	reviewed	Enzyme	AKR1B10	IC50	'='	160000	nM
P37059	BXGT009957	Estradiol 17-beta-dehydrogenase 2	reviewed	Enzyme	HSD17B2	Activity	'='	23	%
O95149	BXGT005350	Snurportin-1	reviewed	-	SNUPN	Potency	-	10000	nM
Q14974	BXGT013516	Importin subunit beta-1	reviewed	Transporter	KPNB1	Potency	-	10000	nM
P47989	BXGT010602	Xanthine dehydrogenase/oxidase	reviewed	Enzyme	XDH	IC50	'='	38000	nM
P25099	BXGT009016	Adenosine receptor A1	reviewed	-	Adora1	Ki	'='	3030	nM
P37058	BXGT009956	Testosterone 17-beta-dehydrogenase 3	reviewed	-	HSD17B3	Inhibition	-	-	-
P37059	BXGT009957	Estradiol 17-beta-dehydrogenase 2	reviewed	Enzyme	HSD17B2	IC50	'>'	20000	nM
P0DP23	BXGT007520	Calmodulin-1	reviewed	-	CALM1	Ratio IC50	'='	0	-
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	reviewed	Enzyme	ALDH2	NI	-	-	-
P16050	BXGT008184	Arachidonate 15-lipoxygenase	reviewed	Enzyme	ALOX15	IC50	'>'	100000	nM
P43140	BXGT010360	Alpha-1A adrenergic receptor	reviewed	-	Adra1a	Kd	'='	246	nM
P23944	BXGT008930	Alpha-1D adrenergic receptor	reviewed	-	Adra1d	Kd	'='	246	nM
P15823	BXGT008160	Alpha-1B adrenergic receptor	reviewed	-	Adra1b	Kd	'='	246	nM
P16116	BXGT008197	Aldo-keto reductase family 1 member B1	reviewed	-	AKR1B1	IC50	'='	45210	nM
P11388	BXGT007697	DNA topoisomerase 2-alpha	reviewed	-	TOP2A	Activity	-	-	-
P15207	BXGT008096	Androgen receptor	reviewed	-	Ar	IC50	'>'	42657	nM
P27338	BXGT009172	Amine oxidase [flavin-containing] B	reviewed	-	MAOB	IC50	'='	120	nM
P21397	BXGT008644	Amine oxidase [flavin-containing] A	reviewed	-	MAOA	IC50	'='	120	nM
P14061	BXGT007979	Estradiol 17-beta-dehydrogenase 1	reviewed	Enzyme	HSD17B1	Activity	'='	16	%
Q965D6	BXGT019601	3-oxoacyl-acyl-carrier protein reductase	unreviewed	-	fabG	Activity	-	-	-
P25099	BXGT009016	Adenosine receptor A1	reviewed	-	Adora1	pKi(uM)	'='	0	-
P0DMS8	BXGT007506	Adenosine receptor A3	reviewed	G-protein coupled receptor	ADORA3	pKi(uM)	-	-	-
O15296	BXGT004148	Arachidonate 15-lipoxygenase B	reviewed	Enzyme	ALOX15B	IC50	'>'	100000	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	16360	nM
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	reviewed	Enzyme	BRCA1	Potency	-	10000	nM
P30543	BXGT009437	Adenosine receptor A2a	reviewed	-	Adora2a	pKi(uM)	'='	0	-
P18054	BXGT008370	Arachidonate 12-lipoxygenase, 12S-type	reviewed	Enzyme	ALOX12	IC50	'>'	100000	nM
O95149	BXGT005350	Snurportin-1	reviewed	-	SNUPN	Potency	-	5173	nM
Q14974	BXGT013516	Importin subunit beta-1	reviewed	Transporter	KPNB1	Potency	-	5173	nM
P62826	BXGT011463	GTP-binding nuclear protein Ran	reviewed	Enzyme modulator	RAN	Potency	-	5173	nM
P16116	BXGT008197	Aldo-keto reductase family 1 member B1	reviewed	-	AKR1B1	IC50	'='	14650	nM
P37058	BXGT009956	Testosterone 17-beta-dehydrogenase 3	reviewed	-	HSD17B3	IC50	'='	66980	nM
P06239	BXGT006427	Tyrosine-protein kinase Lck	reviewed	Kinase	LCK	IC50	'='	80	ug.mL-1
Q965D7	BXGT019602	Beta-hydroxyacyl-ACP dehydratase	unreviewed	-	fabZ	IC50	'='	20000	nM
Q965D5	BXGT019600	Enoyl-acyl-carrier protein reductase	unreviewed	-	fabI	Activity	-	-	-
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	Ki	'='	3430	nM
Q9ES14	BXGT020314	Gamma-aminobutyric acid receptor subunit epsilon	reviewed	-	Gabre	GABA ratio	'='	1	-
Q91ZM7	BXGT019327	GABA theta subunit	unreviewed	-	Gabrq	GABA ratio	'='	1	-
P63138	BXGT011502	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	-	Gabrb2	GABA ratio	'='	1	-
P63079	BXGT011491	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	-	Gabrb3	GABA ratio	'='	1	-
P62813	BXGT011460	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	-	Gabra1	GABA ratio	'='	1	-
P30191	BXGT009410	Gamma-aminobutyric acid receptor subunit alpha-6	reviewed	-	Gabra6	GABA ratio	'='	1	-
P28473	BXGT009261	Gamma-aminobutyric acid receptor subunit gamma-3	reviewed	-	Gabrg3	GABA ratio	'='	1	-
P28471	BXGT009259	Gamma-aminobutyric acid receptor subunit alpha-4	reviewed	-	Gabra4	GABA ratio	'='	1	-
P23576	BXGT008885	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	-	Gabra2	GABA ratio	'='	1	-
P23574	BXGT008884	Gamma-aminobutyric acid receptor subunit gamma-1	reviewed	-	Gabrg1	GABA ratio	'='	1	-
P20236	BXGT008551	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	-	Gabra3	GABA ratio	'='	1	-
P19969	BXGT008536	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	-	Gabra5	GABA ratio	'='	1	-
P18508	BXGT008412	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	-	Gabrg2	GABA ratio	'='	1	-
P18506	BXGT008410	Gamma-aminobutyric acid receptor subunit delta	reviewed	-	Gabrd	GABA ratio	'='	1	-
P15431	BXGT008122	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	-	Gabrb1	GABA ratio	'='	1	-
O09028	BXGT004049	Gamma-aminobutyric acid receptor subunit pi	reviewed	-	Gabrp	GABA ratio	'='	1	-
P0DMS8	BXGT007506	Adenosine receptor A3	reviewed	G-protein coupled receptor	ADORA3	Displacement	'='	41	%
P04150	BXGT006154	Glucocorticoid receptor	reviewed	Nuclear receptor	NR3C1	Activity	-	-	-
P04150	BXGT006154	Glucocorticoid receptor	reviewed	Nuclear receptor	NR3C1	EC150	'='	3	uM
P0DP23	BXGT007520	Calmodulin-1	reviewed	-	CALM1	IC50	'='	37100	nM
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	Ki	'='	2320	nM
P11309	BXGT007685	Serine/threonine-protein kinase pim-1	reviewed	Kinase	PIM1	#NAME?	'='	-1	uM
P08183	BXGT006741	ATP-dependent translocase ABCB1	reviewed	Transporter	ABCB1	Kd	'='	34673	nM
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	reviewed	Enzyme	AKR1B10	Ratio IC50	'='	10	-
P05067	BXGT006306	Amyloid-beta precursor protein	reviewed	Enzyme modulator	APP	IC50	-	-	-
O43570	BXGT004601	Carbonic anhydrase 12	reviewed	-	CA12	Ki	'='	8510	nM
Q16790	BXGT013670	Carbonic anhydrase 9	reviewed	-	CA9	Ki	'='	4920	nM
O43570	BXGT004601	Carbonic anhydrase 12	reviewed	-	CA12	Ki	'='	8400	nM
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	Inhibition	'='	0	%
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	IC50	'>'	100000	nM
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	Ki	'='	3370	nM
P10275	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	EC150	'='	3	uM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	IC50	'='	240	nM
P14061	BXGT007979	Estradiol 17-beta-dehydrogenase 1	reviewed	Enzyme	HSD17B1	IC50	'='	5250	nM
P0DP23	BXGT007520	Calmodulin-1	reviewed	-	CALM1	Inhibition	-	-	-
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	Inhibition	'='	24	%
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	IC50	'='	85000	nM
Q16790	BXGT013670	Carbonic anhydrase 9	reviewed	-	CA9	Ki	'='	4850	nM
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	Inhibition	'='	53	%
Q16678	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	IC50	'='	250	nM
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	reviewed	Enzyme	AKR1B1	IC50	'='	12300	nM
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	reviewed	Enzyme	AKR1B10	IC50	'='	8300	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	25929	nM
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	reviewed	Enzyme	AKR1B10	Inhibition	-	-	-
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	Ki	'='	2240	nM
P05067	BXGT006306	Amyloid-beta precursor protein	reviewed	Enzyme modulator	APP	Inhibition	'='	27	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF02963	Jasminum sambac	Jasminum sambac	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}