Showing entry for Fluorouracil


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0050471
Compound NameFluorouracil
Structure
FormulaC4H3FN2O2
InchiKeyGHASVSINZRGABV-UHFFFAOYSA-N
SMILESOc1ncc(c(n1)O)F
InchiInChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
IUPAC5-fluoro-1H-pyrimidine-2,4-dione
Molecular Weight130.02
Pubchem Id3385
Chembl IdCHEMBL185
Targets of Information Source
DrugBank DB00544
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P04818 BXGT006269 Thymidylate synthase reviewed Enzyme TYMS approved incorporation into and destabilization
PDB URF
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q28943 BXGT013956 Dihydropyrimidine dehydrogenase [NADP(+)] reviewed DPYD - - - - -
P12758 BXGT007845 Uridine phosphorylase reviewed udp - - - - -
Q26998 BXGT013924 Uracil phosphoribosyltransferase reviewed uprt - 25000 - - -
A5PJH9 BXGT001350 Uridine phosphorylase unreviewed UPP1 - - - - -
Q80J95 BXGT017278 Polyprotein unreviewed - - - - -
Q16831 BXGT013677 Uridine phosphorylase 1 reviewed UPP1 Enzyme - - - -
P0A1F6 BXGT006985 Uridine phosphorylase reviewed udp - - - - -
D9J2T9 BXGT003028 Ribosome inactivating protein unreviewed RIP - - - - -
G4VGI0 BXGT003512 Putative uridine phosphorylase reviewed UPPA - - - - -
P9WFQ9 BXGT012247 Uracil-DNA glycosylase reviewed ung - - - - -
P9WHK3 BXGT023101 Bifunctional protein PyrR [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase reviewed pyrR - - - - -
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform reviewed PIK3CA Kinase - - - -
Q9I676 BXGT024661 D-hydantoinase/dihydropyrimidinase reviewed dht - - - 133200 -
Binding DB 50340677
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006648 Thymidylate synthase reviewed Tyms - 7000 - -
reviewed BXGT006648 Thymidylate synthase reviewed Tyms - 220 - -
reviewed BXGT006648 Thymidylate synthase reviewed Tyms - 20 - -
reviewed BXGT006648 Thymidylate synthase reviewed Tyms - 600 - -
reviewed BXGT006648 Thymidylate synthase reviewed Tyms - 60 - -
CHEMBL CHEMBL185
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 158 nM
Q8BW75 BXGT017924 Amine oxidase [flavin-containing] B reviewed - Maob Activity - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 14381 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 794 nM
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 8492 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P07607 BXGT006648 Thymidylate synthase reviewed - Tyms IC50 '>=' 10000 nM
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 12 nM
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 31622 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 11220 nM
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P0A6C1 BXGT007045 Endonuclease 4 reviewed - nfo Potency '=' 8912 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P07607 BXGT006648 Thymidylate synthase reviewed - Tyms IC50 '=' 20 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 37650 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 3262 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 50118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 14963 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 25118 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 23280 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform reviewed Kinase PIK3CA Inhibition '<' 25 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1258 nM
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 5619 nM
P04818 BXGT006269 Thymidylate synthase reviewed Enzyme TYMS Activity - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 11582 nM
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform reviewed Kinase PIK3CA Inhibition '<' 25 %
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha reviewed Kinase PIK3R1 Inhibition '<' 25 %
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 5011 nM
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 12589 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 11 nM
O88909 BXGT005288 Solute carrier family 22 member 8 reviewed - Slc22a8 Km '=' 53 nM
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P07607 BXGT006648 Thymidylate synthase reviewed - Tyms IC50 '=' 60 nM
P38889 BXGT010069 Transcription factor SKN7 reviewed - SKN7 AbsAC40_uM - 9 uM
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 22 nM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 56234 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Inhibition - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 2592 nM
Q8IL88 BXGT018311 HSP40, subfamily A, putative unreviewed - PF3D7_1437900 AbsAC1000_uM '=' 0 uM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 1258 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P0A8F0 BXGT007144 Uracil phosphoribosyltransferase reviewed - upp Ki '=' 13000 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 1000000 nM
P07607 BXGT006648 Thymidylate synthase reviewed - Tyms IC50 '=' 600 nM
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P42858 BXGT010341 Huntingtin reviewed - HTT Potency '=' 1995 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 86 %
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 1000 nM
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 28183 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 631 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
Q64133 BXGT016109 Amine oxidase [flavin-containing] A reviewed - Maoa Activity - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 158489 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Potency - 18356 nM
P07607 BXGT006648 Thymidylate synthase reviewed - Tyms IC50 '=' 220 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 3162 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 150 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 5623 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 446 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 125 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 100000 nM
O15440 BXGT004170 Multidrug resistance-associated protein 5 reviewed Transporter ABCC5 Activity '=' 59 %
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 91 %
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 22 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 35481 nM
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 33498 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 2310 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 3981 nM
Q77YF9 BXGT016886 Protein Vpr unreviewed - vpr Potency - 10000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 4775 nM
P07607 BXGT006648 Thymidylate synthase reviewed - Tyms IC50 '=' 7000 nM
O15440 BXGT004170 Multidrug resistance-associated protein 5 reviewed Transporter ABCC5 FC '=' 2 -
P10145 BXGT007542 Interleukin-8 reviewed Signaling CXCL8 Potency - 66824 nM
P04818 BXGT006269 Thymidylate synthase reviewed Enzyme TYMS Inhibition - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 25929 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 26854 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 11220 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 133000 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 133000 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 10590 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 3505 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Inhibition '=' 0 %
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 12995 nM
P47989 BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH Inhibition - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 25118 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 0 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 135000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01788 Patrinia scabra Patrinia scabra Medicinal Plant
BXGF01921 Morus cathayana Morus cathayana Medicinal Plant
BXGF03659 Carpesium faberi Carpesium faberi Others
BXGF05730 Alpinia blepharocalyx Alpinia blepharocalyx Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease