Showing entry for Growth factor receptor-bound protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011480
Protein NameGrowth factor receptor-bound protein 2
Uniport IdP62993
GeneGRB2
Gene Id2885
DomainSH2; SH3_1
Pfam PF00017   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01522 Endocrine resistance
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04012 ErbB signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
5. Organismal Systems 5.1 Immune system hsa04650 Natural killer cell mediated cytotoxicity
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04664 Fc epsilon RI signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04917 Prolactin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05210 Colorectal cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05213 Endometrial cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05214 Glioma
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05220 Chronic myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05221 Acute myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05223 Non-small cell lung cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05224 Breast cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031532 actin cytoskeleton reorganization
Biological Process GO:0007568 aging
Biological Process GO:0048646 anatomical structure formation involved in morphogenesis
Biological Process GO:0007411 axon guidance
Biological Process GO:0060670 branching involved in labyrinthine layer morphogenesis
Biological Process GO:0071479 cellular response to ionizing radiation
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0035635 entry of bacterium into host cell
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0038128 ERBB2 signaling pathway
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:0008543 fibroblast growth factor receptor signaling pathway
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0035723 interleukin-15-mediated signaling pathway
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0061024 membrane organization
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0048011 neurotrophin TRK receptor signaling pathway
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0046579 positive regulation of Ras protein signal transduction
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0031623 receptor internalization
Biological Process GO:0043408 regulation of MAPK cascade
Biological Process GO:0042770 signal transduction in response to DNA damage
Biological Process GO:0031295 T cell costimulation
Biological Process GO:0016032 viral process
molecular function GO:0046875 ephrin receptor binding
molecular function GO:0005154 epidermal growth factor receptor binding
molecular function GO:0042802 identical protein binding
molecular function GO:0043560 insulin receptor substrate binding
molecular function GO:0005168 neurotrophin TRKA receptor binding
molecular function GO:0001784 phosphotyrosine residue binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0003723 RNA binding
molecular function GO:0017124 SH3 domain binding
cellular component GO:0005911 cell-cell junction
cellular component GO:0008180 COP9 signalosome
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0070436 Grb2-EGFR complex
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0012506 vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-449147 Signaling by Interleukins
R-HSA-449147 Signaling by Interleukins
R-HSA-451927 Interleukin-2 family signaling
R-HSA-451927 Interleukin-2 family signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8983432 Interleukin-15 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011882 BXGD000761 Diabetic Neuropathies Nervous System Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023480 BXGD001664 Leukemia, Myelomonocytic, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023891 BXGD001714 Liver Cirrhosis, Alcoholic Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Chemically-Induced Disorders
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028860 BXGD002093 Oculocerebrorenal Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036916 BXGD002643 Sexually Transmitted Diseases Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205682 BXGD004105 Waist-Hip Ratio
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265286 BXGD005500 Dyggve-Melchior-Clausen syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0339467 BXGD007248 Proliferative retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0339470 BXGD007249 Visually threatening diabetic retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0406775 BXGD008371 Symmetrical dyschromatosis of extremities Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0431375 BXGD008677 Classical Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0854917 BXGD011050 Rhabdoid Tumor of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1332182 BXGD012495 Adult Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332942 BXGD012558 Childhood Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512981 BXGD013196 Mammary Tumorigenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1608408 BXGD013434 Malignant transformation
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1827293 BXGD013768 Carcinoma of urinary bladder, invasive Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1959635 BXGD016646 Parvovirus B19 (disease)
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2676191 BXGD017324 PITUITARY ADENOMA, FAMILIAL ISOLATED (disorder) Neoplasms; Nervous System Diseases; Endocrine System Diseases
C2699510 BXGD017460 Split-Hand/Foot Malformation Pathological Conditions, Signs and Symptoms
C2827362 BXGD017794 Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3241958 BXGD018580 Myocardial Disorder Cardiovascular Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733092 BXGD023907 estrogen receptor-negative breast cancer
C4733095 BXGD023910 HER2-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0004266 2-Propanol 60.1
BXGC0004277 Acetic acid 60.05
BXGC0006174 4-Hydroxybenzyl alcohol 124.14
BXGC0006368 Formic acid 46.03
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein