protein

Showing entry for Mineralocorticoid receptor

General Target Information
BXGT Id	BXGT006751
Protein Name	Mineralocorticoid receptor
Uniport Id	P08235
Gene	NR3C2
Gene Id	4306
Domain	Hormone_recep; zf-C4
Pfam	PF00104 PF00105
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.5 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0006367	transcription initiation from RNA polymerase II promoter
molecular function	GO:0003700	DNA-binding transcription factor activity
molecular function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function	GO:0070491	repressing transcription factor binding
molecular function	GO:1990837	sequence-specific double-stranded DNA binding
molecular function	GO:0005496	steroid binding
molecular function	GO:0003707	steroid hormone receptor activity
molecular function	GO:0008270	zinc ion binding
cellular component	GO:0005829	cytosol
cellular component	GO:0005789	endoplasmic reticulum membrane
cellular component	GO:0000790	nuclear chromatin
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0043235	receptor complex

Reactome

Pathway Id	Pathway Name
R-HSA-2262752	Cellular responses to stress
R-HSA-2990846	SUMOylation
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-392499	Metabolism of proteins
R-HSA-4090294	SUMOylation of intracellular receptors
R-HSA-597592	Post-translational protein modification
R-HSA-8953897	Cellular responses to external stimuli

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001126	BXGD000025	Renal tubular acidosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0002170	BXGD000105	Alopecia	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003469	BXGD000195	Anxiety Disorders	Mental Disorders
C0003811	BXGD000222	Cardiac Arrhythmia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0004936	BXGD000295	Mental disorders	Mental Disorders
C0005586	BXGD000315	Bipolar Disorder	Mental Disorders
C0005684	BXGD000319	Malignant neoplasm of urinary bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695	BXGD000323	Bladder Neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006012	BXGD000360	Borderline Personality Disorder	Mental Disorders
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007193	BXGD000451	Cardiomyopathy, Dilated	Cardiovascular Diseases
C0007194	BXGD000452	Hypertrophic Cardiomyopathy	Cardiovascular Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0007682	BXGD000471	CNS disorder	Nervous System Diseases
C0007785	BXGD000485	Cerebral Infarction	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0008626	BXGD000559	Congenital chromosomal disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009404	BXGD000606	Colorectal Neoplasms	Digestive System Diseases; Neoplasms
C0009777	BXGD000630	Conn Adenoma	Neoplasms; Endocrine System Diseases
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0010481	BXGD000673	Cushing Syndrome	Endocrine System Diseases
C0011175	BXGD000701	Dehydration	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011603	BXGD000734	Dermatitis	Skin and Connective Tissue Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0013264	BXGD000808	Muscular Dystrophy, Duchenne	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013473	BXGD000845	Eating Disorders	Mental Disorders
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0014070	BXGD000887	Encephalomyelitis	Infections; Nervous System Diseases
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0014547	BXGD000927	Epilepsies, Partial	Nervous System Diseases
C0014836	BXGD000954	Escherichia coli Infections	Infections
C0015544	BXGD001003	Failure to Thrive	Pathological Conditions, Signs and Symptoms
C0015695	BXGD001013	Fatty Liver	Digestive System Diseases
C0016059	BXGD001043	Fibrosis	Pathological Conditions, Signs and Symptoms
C0018378	BXGD001190	Guillain-Barre Syndrome	Immune System Diseases; Nervous System Diseases
C0018418	BXGD001192	Gynecomastia	Skin and Connective Tissue Diseases
C0018799	BXGD001224	Heart Diseases	Cardiovascular Diseases
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0019158	BXGD001293	Hepatitis	Digestive System Diseases
C0019159	BXGD001294	Hepatitis A	Digestive System Diseases; Infections
C0019337	BXGD001319	Heroin Dependence	Chemically-Induced Disorders; Mental Disorders
C0019348	BXGD001325	Herpes Simplex Infections	Infections; Skin and Connective Tissue Diseases
C0020428	BXGD001377	Hyperaldosteronism	Endocrine System Diseases
C0020429	BXGD001378	Hyperalgesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020443	BXGD001385	Hypercholesterolemia	Nutritional and Metabolic Diseases
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020461	BXGD001395	Hyperkalemia	Nutritional and Metabolic Diseases
C0020473	BXGD001396	Hyperlipidemia	Nutritional and Metabolic Diseases
C0020488	BXGD001402	Hypernatremia	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020557	BXGD001432	Hypertriglyceridemia	Nutritional and Metabolic Diseases
C0020595	BXGD001438	Hypoaldosteronism	Endocrine System Diseases
C0020615	BXGD001445	Hypoglycemia	Nutritional and Metabolic Diseases
C0020625	BXGD001451	Hyponatremia	Nutritional and Metabolic Diseases
C0020649	BXGD001459	Hypotension	Cardiovascular Diseases
C0021368	BXGD001502	Inflammation	Pathological Conditions, Signs and Symptoms
C0022658	BXGD001570	Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660	BXGD001571	Kidney Failure, Acute	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661	BXGD001572	Kidney Failure, Chronic	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023212	BXGD001616	Left-Sided Heart Failure	Cardiovascular Diseases
C0023418	BXGD001642	leukemia	Neoplasms
C0023440	BXGD001646	Acute Erythroblastic Leukemia	Neoplasms; Hemic and Lymphatic Diseases
C0023473	BXGD001661	Myeloid Leukemia, Chronic	Neoplasms; Hemic and Lymphatic Diseases
C0023787	BXGD001698	Lipodystrophy	Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0024117	BXGD001734	Chronic Obstructive Airway Disease	Respiratory Tract Diseases
C0024301	BXGD001759	Lymphoma, Follicular	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024440	BXGD001774	Macular Edema, Cystoid	Eye Diseases
C0025048	BXGD001823	Meconium Aspiration Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Respiratory Tract Diseases
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026850	BXGD001942	Muscular Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027726	BXGD002030	Nephrotic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029182	BXGD002121	orbit (eye disorders)	Eye Diseases
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0030779	BXGD002252	Pelger-Huet Anomaly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0030809	BXGD002258	Pemphigus Vulgaris	Skin and Connective Tissue Diseases; Immune System Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0032580	BXGD002362	Adenomatous Polyposis Coli	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033036	BXGD002389	Atrial Premature Complexes	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0033687	BXGD002415	Proteinuria	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0033805	BXGD002427	Pseudohypoaldosteronism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035078	BXGD002505	Kidney Failure	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035305	BXGD002529	Retinal Detachment	Eye Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0037274	BXGD002676	Dermatologic disorders	Skin and Connective Tissue Diseases
C0037315	BXGD002687	Sleep Apnea Syndromes	Respiratory Tract Diseases; Nervous System Diseases
C0038436	BXGD002755	Post-Traumatic Stress Disorder	Mental Disorders
C0038443	BXGD002757	Stress, Psychological	Behavior and Behavior Mechanisms
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0040822	BXGD002885	Tremor	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041696	BXGD002932	Unipolar Depression	Mental Disorders
C0041956	BXGD002942	Ureteral obstruction	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042029	BXGD002951	Urinary tract infection	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0042164	BXGD002965	Uveitis	Eye Diseases
C0042373	BXGD002978	Vascular Diseases	Cardiovascular Diseases
C0042963	BXGD003018	Vomiting	Pathological Conditions, Signs and Symptoms
C0085281	BXGD003152	Addictive Behavior	Behavior and Behavior Mechanisms
C0085580	BXGD003191	Essential Hypertension	Cardiovascular Diseases
C0085612	BXGD003204	Ventricular arrhythmia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0086132	BXGD003264	Depressive Symptoms	Behavior and Behavior Mechanisms
C0086543	BXGD003294	Cataract	Eye Diseases
C0149721	BXGD003349	Left Ventricular Hypertrophy	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151514	BXGD003429	Atrophic condition of skin	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0151620	BXGD003448	Hypertensive Encephalopathy	Nervous System Diseases
C0151650	BXGD003454	Renal fibrosis	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0152105	BXGD003541	Hypertensive heart disease	Cardiovascular Diseases
C0155626	BXGD003806	Acute myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162871	BXGD003996	Aortic Aneurysm, Abdominal	Cardiovascular Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0220748	BXGD004336	Cartilage-hair hypoplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Musculoskeletal Diseases; Immune System Diseases
C0220981	BXGD004348	Metabolic acidosis	Nutritional and Metabolic Diseases
C0221002	BXGD004360	Hyperparathyroidism, Primary	Endocrine System Diseases
C0221043	BXGD004377	Liddle Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0221074	BXGD004388	Depression, Postpartum	Female Urogenital Diseases and Pregnancy Complications; Mental Disorders
C0232466	BXGD004543	Feeding difficulties
C0233472	BXGD004579	Labile affect
C0233794	BXGD004618	Memory impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235527	BXGD004753	Heart Failure, Right-Sided	Cardiovascular Diseases
C0236734	BXGD004823	Caffeine related disorders
C0240783	BXGD005054	Increased circulating renin level
C0242292	BXGD005146	McCune-Albright Syndrome	Musculoskeletal Diseases
C0242339	BXGD005150	Dyslipidemias	Nutritional and Metabolic Diseases
C0242698	BXGD005189	Ventricular Dysfunction, Left	Cardiovascular Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0262655	BXGD005264	Recurrent urinary tract infection	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0264714	BXGD005416	Acute heart failure	Cardiovascular Diseases
C0264716	BXGD005417	Chronic heart failure	Cardiovascular Diseases
C0268287	BXGD005884	Deficiency of steroid 21-monooxygenase	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0268436	BXGD005946	Pseudohypoaldosteronism, Type I	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268790	BXGD006039	Renal vascular disorder	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0269102	BXGD006053	Endometrioma	Female Urogenital Diseases and Pregnancy Complications
C0271051	BXGD006153	Macular retinal edema	Eye Diseases
C0271084	BXGD006159	Exudative age-related macular degeneration	Eye Diseases
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0278488	BXGD006515	Carcinoma breast stage IV
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0332853	BXGD006901	Anastomosis
C0334108	BXGD006994	Multiple polyps	Pathological Conditions, Signs and Symptoms
C0338106	BXGD007167	Adenocarcinoma of colon	Digestive System Diseases; Neoplasms
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0339383	BXGD007245	Choroidal and/or chorioretinal disorder	Eye Diseases
C0340100	BXGD007304	High altitude pulmonary edema	Respiratory Tract Diseases
C0342257	BXGD007447	Complications of Diabetes Mellitus	Endocrine System Diseases
C0342443	BXGD007481	Adrenal Cushing's syndrome	Endocrine System Diseases
C0342488	BXGD007488	Mineralocorticoid Excess Syndrome, Apparent	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0403592	BXGD008297	Chronic rejection of renal transplant	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0432215	BXGD008739	Progressive pseudorheumatoid dysplasia	Musculoskeletal Diseases
C0494463	BXGD009029	Alzheimer Disease, Late Onset	Nervous System Diseases; Mental Disorders
C0494791	BXGD009034	Hepatic fibrosis and cirrhosis	Digestive System Diseases
C0520463	BXGD009085	Chronic active hepatitis	Digestive System Diseases
C0520679	BXGD009101	Sleep Apnea, Obstructive	Respiratory Tract Diseases; Nervous System Diseases
C0521170	BXGD009131	Osteoporotic Fractures	Wounds and Injuries
C0521991	BXGD009187	Symptoms of stress
C0524528	BXGD009229	Pervasive Development Disorder	Mental Disorders
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0525045	BXGD009255	Mood Disorders	Mental Disorders
C0542476	BXGD009276	Forgetful	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0556374	BXGD009442	Drunk driving	Chemically-Induced Disorders; Mental Disorders
C0565599	BXGD009488	Maternal hypertension	Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0588007	BXGD009619	Moderate depression	Mental Disorders
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0677607	BXGD009721	Hashimoto Disease	Endocrine System Diseases
C0677660	BXGD009725	Emotional problems	Mental Disorders
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0699885	BXGD009869	Carcinoma of bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0730314	BXGD009955	Chronic central serous chorioretinopathy	Pathological Conditions, Signs and Symptoms; Eye Diseases
C0730328	BXGD009959	Central Serous Chorioretinopathy	Eye Diseases
C0740391	BXGD009987	Middle Cerebral Artery Occlusion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740394	BXGD009989	Hyperuricemia	Pathological Conditions, Signs and Symptoms
C0741923	BXGD010045	cardiac event
C0741949	BXGD010047	Cardiovascular Pathology
C0745130	BXGD010117	Resistant hypertensive disorder	Cardiovascular Diseases
C0852036	BXGD010934	Pregnancy associated hypertension	Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0852654	BXGD010947	21-hydroxylase deficiency
C0856169	BXGD011096	Endothelial dysfunction
C0856742	BXGD011111	Post MI	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0857899	BXGD011166	Decreased circulating aldosterone level	Immune System Diseases; Endocrine System Diseases
C0871388	BXGD011314	social stress	Behavior and Behavior Mechanisms
C0878544	BXGD011368	Cardiomyopathies	Cardiovascular Diseases
C0917996	BXGD011425	Cerebral Aneurysm	Nervous System Diseases; Cardiovascular Diseases
C0920646	BXGD011471	Ischemia of kidney	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0947751	BXGD011494	Vascular inflammations	Cardiovascular Diseases
C0948008	BXGD011499	Ischemic stroke	Nervous System Diseases; Cardiovascular Diseases
C0948089	BXGD011504	Acute Coronary Syndrome	Cardiovascular Diseases
C0948201	BXGD011515	Alloimmunisation
C0948807	BXGD011558	Hepatic impairment
C1096155	BXGD011605	Macrophage Activation Syndrome	Immune System Diseases
C1135191	BXGD011692	Heart Failure, Systolic	Cardiovascular Diseases
C1260386	BXGD011828	Glucocorticoid-remediable aldosteronism	Endocrine System Diseases
C1263846	BXGD011897	Attention deficit hyperactivity disorder	Mental Disorders
C1269683	BXGD012001	Major Depressive Disorder	Mental Disorders
C1269955	BXGD012005	Tumor Cell Invasion
C1277187	BXGD012109	Left ventricular systolic dysfunction	Cardiovascular Diseases
C1280433	BXGD012125	Lipoatrophy	Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1290807	BXGD012195	Diarrheal disorder	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1291311	BXGD012207	Deficiency of dehydrogenase
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1332977	BXGD012569	Childhood Leukemia	Neoplasms
C1384514	BXGD012940	Conn Syndrome	Endocrine System Diseases
C1397307	BXGD012996	Cardiac fibrosis
C1449563	BXGD013086	Cardiomyopathy, Familial Idiopathic	Cardiovascular Diseases
C1449842	BXGD013093	Pseudohypoaldosteronism, Type I, Autosomal Dominant	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1449843	BXGD013094	Pseudohypoaldosteronism, Type I, Autosomal Recessive	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1449844	BXGD013095	Pseudohypoaldosteronism, Type II	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1510586	BXGD013176	Autism Spectrum Disorders	Mental Disorders
C1512409	BXGD013188	Hepatocarcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C1536220	BXGD013341	ST segment elevation myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1561643	BXGD013363	Chronic Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489	BXGD013401	Renal Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1609524	BXGD013440	ADHF
C1611743	BXGD013456	Familial (FPAH)
C1623038	BXGD013475	Cirrhosis	Pathological Conditions, Signs and Symptoms
C1832661	BXGD013866	ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1841972	BXGD014484	Glucocorticoid Receptor Deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1842981	BXGD014547	NEUROTICISM	Behavior and Behavior Mechanisms
C1845206	BXGD014727	Decreased circulating renin level
C1846345	BXGD014801	Hyperactive renin-angiotensin system
C1854631	BXGD015417	Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy	Cardiovascular Diseases
C1857276	BXGD015688	Trichohepatoenteric Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C1959583	BXGD016637	Myocardial Failure	Cardiovascular Diseases
C1961112	BXGD016674	Heart Decompensation	Cardiovascular Diseases
C1969372	BXGD016775	Tubulointerstitial fibrosis
C2004489	BXGD016873	Regurgitation
C2020625	BXGD016882	Group B Streptococcal Infection	Infections
C2062372	BXGD016895	Adrenal hyperplasia, bilateral
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2315100	BXGD017021	Pediatric failure to thrive	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2316810	BXGD017030	Chronic kidney disease stage 5	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2713447	BXGD017501	Hyperpotassemia and Hypertension, Familial	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2732473	BXGD017555	Ductal Carcinoma In Situ with Microinvasion
C2931822	BXGD018068	Nasopharyngeal carcinoma	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2936858	BXGD018147	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2960127	BXGD018197	Heart failure with normal ejection fraction	Cardiovascular Diseases
C2973725	BXGD018205	Pulmonary arterial hypertension	Respiratory Tract Diseases; Cardiovascular Diseases
C3160718	BXGD018468	PARKINSON DISEASE, LATE-ONSET
C3203102	BXGD018555	Idiopathic pulmonary arterial hypertension	Respiratory Tract Diseases
C3539878	BXGD019087	Triple Negative Breast Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C3838731	BXGD019760	Familial hyperaldosteronism type 1	Endocrine System Diseases
C3875321	BXGD019874	Inflammatory dermatosis	Skin and Connective Tissue Diseases
C3887551	BXGD019898	Memory dysfunction	Mental Disorders
C3887638	BXGD019906	Failure to thrive in infant	Pathological Conditions, Signs and Symptoms
C3887949	BXGD019932	Apparent mineralocorticoid excess	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3888198	BXGD019958	BESTROPHINOPATHY, AUTOSOMAL RECESSIVE	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4020969	BXGD020517	Inflammatory abnormality of the eye
C4021821	BXGD020806	Abnormality of the urinary system	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4083008	BXGD022100	Guillain-Barre Syndrome, Familial	Immune System Diseases; Nervous System Diseases
C4324685	BXGD022776	Hypertensive end-organ damage
C4509226	BXGD022972	Heart failure with preserved ejection fraction [HFpEF]
C4551689	BXGD023393	Sleep-Disordered Breathing	Respiratory Tract Diseases; Nervous System Diseases
C4552766	BXGD023523	Miscarriage	Female Urogenital Diseases and Pregnancy Complications
C4699152	BXGD023634	ST-segment elevation myocardial infarction (STEMI)
C4722518	BXGD023806	Triple-Negative Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C4725020	BXGD023821	Moderate Hepatic Insufficiency	Digestive System Diseases
C4733095	BXGD023910	HER2-negative breast cancer

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09
BXGC0000441	Dimethyl sulfoxide		78.13
BXGC0001325	Progesterone		314.46
BXGC0002591	Potassium		39.1
BXGC0003611	Latex		416.57
BXGC0003705	Chloride		35.45
BXGC0020800	Testosterone		288.21
BXGC0022231	Ursodiol		392.29
BXGC0024141	Hydrocortisone		362.21
BXGC0035101	Guggulsterone		312.21
BXGC0037687	(4S)-2-methylpentane-2,4-diol		118.1
BXGC0038988	testosterone enanthate		400.3
BXGC0040531	Lecanindole D		353.24
BXGC0053216	(R)-Sargachromenol		424.26
BXGC0053840	Lecanindole B		351.22

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}