protein

Showing entry for Complement factor I

General Target Information
BXGT Id	BXGT006329
Protein Name	Complement factor I
Uniport Id	P05156
Gene	CFI
Gene Id	3426
Domain	Ldl_recept_a; SRCR; Trypsin
Pfam	PF00057 PF00530 PF00089
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.1 Immune system	hsa04610	Complement and coagulation cascades
6. Human Diseases	6.8 Infectious diseases: Bacterial	hsa05150	Staphylococcus aureus infection

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006958	complement activation, classical pathway
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0030449	regulation of complement activation
Biological Process	GO:0016032	viral process
molecular function	GO:0046872	metal ion binding
molecular function	GO:0005044	scavenger receptor activity
molecular function	GO:0004252	serine-type endopeptidase activity
cellular component	GO:0070062	extracellular exosome
cellular component	GO:0005576	extracellular region
cellular component	GO:0005615	extracellular space
cellular component	GO:0016020	membrane

Reactome

Pathway Id	Pathway Name
R-HSA-166658	Complement cascade
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-977606	Regulation of Complement cascade

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000737	BXGD000005	Abdominal Pain	Pathological Conditions, Signs and Symptoms
C0000832	BXGD000013	Abruptio Placentae	Female Urogenital Diseases and Pregnancy Complications
C0001733	BXGD000073	Afibrinogenemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0003460	BXGD000191	Anuria	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003469	BXGD000195	Anxiety Disorders	Mental Disorders
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0004604	BXGD000278	Back Pain	Pathological Conditions, Signs and Symptoms
C0004623	BXGD000282	Bacterial Infections	Infections
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006267	BXGD000383	Bronchiectasis	Respiratory Tract Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0010674	BXGD000683	Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0012739	BXGD000786	Disseminated Intravascular Coagulation	Hemic and Lymphatic Diseases
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0014077	BXGD000889	Leukoencephalitis, Acute Hemorrhagic	Immune System Diseases; Nervous System Diseases
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0015672	BXGD001011	Fatigue	Pathological Conditions, Signs and Symptoms
C0017658	BXGD001138	Glomerulonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017921	BXGD001152	Glycogen storage disease type II	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018681	BXGD001214	Headache	Pathological Conditions, Signs and Symptoms
C0018781	BXGD001219	Noise-induced hearing loss	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018965	BXGD001258	Hematuria	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019048	BXGD001270	Hemoglobinuria	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019061	BXGD001273	Hemolytic-Uremic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C0019250	BXGD001309	Hereditary factor I deficiency disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020649	BXGD001459	Hypotension	Cardiovascular Diseases
C0021359	BXGD001498	Infertility	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022658	BXGD001570	Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023530	BXGD001683	Leukopenia	Hemic and Lymphatic Diseases
C0023903	BXGD001720	Liver neoplasms	Digestive System Diseases; Neoplasms
C0024121	BXGD001735	Lung Neoplasms	Neoplasms; Respiratory Tract Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0027092	BXGD001971	Myopia	Eye Diseases
C0027497	BXGD001993	Nausea	Pathological Conditions, Signs and Symptoms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027947	BXGD002061	Neutropenia	Hemic and Lymphatic Diseases
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0032227	BXGD002336	Pleural effusion disorder	Respiratory Tract Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0032914	BXGD002379	Pre-Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0033687	BXGD002415	Proteinuria	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034063	BXGD002453	Pulmonary Edema	Respiratory Tract Diseases
C0034186	BXGD002469	Pyelonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0037011	BXGD002656	Shoulder Pain	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0037199	BXGD002671	Sinusitis	Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0038356	BXGD002747	Stomach Neoplasms	Digestive System Diseases; Neoplasms
C0040034	BXGD002836	Thrombocytopenia	Hemic and Lymphatic Diseases
C0042164	BXGD002965	Uveitis	Eye Diseases
C0042170	BXGD002969	Uveomeningoencephalitic Syndrome	Eye Diseases; Immune System Diseases; Nervous System Diseases
C0042384	BXGD002979	Vasculitis	Cardiovascular Diseases
C0042963	BXGD003018	Vomiting	Pathological Conditions, Signs and Symptoms
C0043094	BXGD003026	Weight Gain	Pathological Conditions, Signs and Symptoms
C0151436	BXGD003417	Vasculitis, Leukocytoclastic, Cutaneous	Immune System Diseases; Cardiovascular Diseases
C0151539	BXGD003435	Blood urea increased	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151603	BXGD003445	Anasarca	Pathological Conditions, Signs and Symptoms
C0151872	BXGD003493	Prothrombin time increased	Hemic and Lymphatic Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0152259	BXGD003576	Cataract secondary to ocular disorder	Eye Diseases
C0162739	BXGD003979	HELLP Syndrome	Female Urogenital Diseases and Pregnancy Complications
C0221021	BXGD004368	Microangiopathic hemolytic anemia	Hemic and Lymphatic Diseases
C0232493	BXGD004550	Epigastric pain	Pathological Conditions, Signs and Symptoms
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0242383	BXGD005160	Age related macular degeneration	Eye Diseases
C0262655	BXGD005264	Recurrent urinary tract infection	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0262988	BXGD005278	Vasculitis of the skin	Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0271084	BXGD006159	Exudative age-related macular degeneration	Eye Diseases
C0272242	BXGD006330	Complement deficiency disease	Immune System Diseases; Hemic and Lymphatic Diseases
C0280100	BXGD006713	Solid Neoplasm	Neoplasms
C0302810	BXGD006853	Uremia syndrome	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0345967	BXGD007756	Malignant mesothelioma	Neoplasms; Respiratory Tract Diseases
C0423428	BXGD008485	Scarred macula	Pathological Conditions, Signs and Symptoms
C0427437	BXGD008615	MCH - low
C0438696	BXGD008805	Suicidal	Behavior and Behavior Mechanisms
C0553681	BXGD009406	Hypofibrinogenemia
C0565599	BXGD009488	Maternal hypertension	Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0581354	BXGD009561	Recurrent sinusitis	Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0600518	BXGD009711	Choroidal Neovascularization	Pathological Conditions, Signs and Symptoms; Eye Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0700225	BXGD009882	Serum creatinine raised	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0701807	BXGD009901	Acute anterior uveitis	Eye Diseases
C0746495	BXGD010143	Recurrent meningitis	Infections; Nervous System Diseases
C0747085	BXGD010158	Recurrent otitis media	Otorhinolaryngologic Diseases
C0860603	BXGD011236	Anxiety symptoms
C0876973	BXGD011322	Infectious Lung Disorder	Infections; Respiratory Tract Diseases
C1112472	BXGD011671	Aeromonas hydrophila infection
C1260959	BXGD011846	Drusen
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1504336	BXGD013137	Polypoidal choroidal vasculopathy
C1536085	BXGD013334	Geographic Atrophy	Eye Diseases
C1565489	BXGD013401	Renal Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704272	BXGD013537	Benign Prostatic Hyperplasia	Male Urogenital Diseases
C1832174	BXGD013807	DOYNE HONEYCOMB RETINAL DYSTROPHY	Eye Diseases; Nervous System Diseases
C1837512	BXGD014243	Decreased serum complement C3
C1839364	BXGD014371	Progressive visual loss
C1848701	BXGD014967	Elevated hepatic transaminase
C1850534	BXGD015149	Edema, generalized	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C1851789	BXGD015233	Poor wound healing
C1852020	BXGD015254	Malattia Leventinese	Eye Diseases; Nervous System Diseases
C1852021	BXGD015255	Drusen, Radial, Autosomal Dominant	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1853193	BXGD015312	Recurrent skin infections	Infections; Skin and Connective Tissue Diseases
C1969222	BXGD016765	Decreased serum complement factor H
C1970257	BXGD016826	Decreased serum complement factor I
C1970263	BXGD016827	Recurrent meningococcal disease
C2169794	BXGD016933	Recurrent streptococcus pneumoniae infections
C2237660	BXGD016962	exudative macular degeneration	Eye Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2609414	BXGD017182	Acute kidney injury	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2717961	BXGD017519	Thrombotic Microangiopathies	Hemic and Lymphatic Diseases
C2752039	BXGD017759	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 3
C2931788	BXGD018064	Atypical Hemolytic Uremic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C2937358	BXGD018159	Cerebral Hemorrhage	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C2973529	BXGD018204	Leukocytoclastic vasculitis	Immune System Diseases; Cardiovascular Diseases
C3463916	BXGD018901	Complement Factor I (C3 inactivator) deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C3539878	BXGD019087	Triple Negative Breast Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C3809523	BXGD019596	MACULAR DEGENERATION, AGE-RELATED, 13
C4016436	BXGD020333	MACULAR DEGENERATION, AGE-RELATED, 13, SUSCEPTIBILITY TO
C4021636	BXGD020710	Decreased serum complement factor B
C4025204	BXGD021590	Recurrent Haemophilus influenzae infections
C4055342	BXGD021999	C3 Glomerulonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4087273	BXGD022140	C3 glomerulopathy
C4316812	BXGD022704	Fibrinogen Deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4477095	BXGD022922	Increased lactate dehydrogenase activity
C4552000	BXGD023473	Episodic Kinesigenic Dyskinesia 1	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4554651	BXGD023568	Generalized Edema, CTCAE
C4721766	BXGD023764	Unspecified secondary cataract	Eye Diseases
C4722518	BXGD023806	Triple-Negative Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002586	Calcium		40.08
BXGC0002616	Copper		63.55
BXGC0002682	Zinc		65.41

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}