Showing entry for Follicle-stimulating hormone receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008931
Protein NameFollicle-stimulating hormone receptor
Uniport IdP23945
GeneFSHR
Gene Id2492
Domain7tm_1; GnHR_trans; LRRNT; LRR_5
Pfam PF00001   PF12369   PF13306   PF01462  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007190 activation of adenylate cyclase activity
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0071372 cellular response to follicle-stimulating hormone stimulus
Biological Process GO:0007292 female gamete generation
Biological Process GO:0008585 female gonad development
Biological Process GO:0042699 follicle-stimulating hormone signaling pathway
Biological Process GO:0008406 gonad development
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0009755 hormone-mediated signaling pathway
Biological Process GO:0008584 male gonad development
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0010738 regulation of protein kinase A signaling
Biological Process GO:0007283 spermatogenesis
molecular function GO:0004963 follicle-stimulating hormone receptor activity
molecular function GO:0008528 G protein-coupled peptide receptor activity
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000731 BXGD000002 Abdomen distended Digestive System Diseases
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0000846 BXGD000015 Agenesis
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002453 BXGD000117 Amenorrhea Pathological Conditions, Signs and Symptoms
C0003128 BXGD000181 Anovulation Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0003706 BXGD000215 Arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0003962 BXGD000244 Ascites Pathological Conditions, Signs and Symptoms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013537 BXGD000853 Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0018050 BXGD001166 Gonadal Disorders Endocrine System Diseases
C0018051 BXGD001167 Gonadal Dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0018206 BXGD001186 granulosa cell tumor Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0019621 BXGD001340 Histiocytosis, Langerhans-Cell Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028960 BXGD002101 Oligospermia Male Urogenital Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029927 BXGD002182 Ovarian Cysts Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032000 BXGD002318 Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0034012 BXGD002449 Delayed Puberty Endocrine System Diseases
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0034063 BXGD002453 Pulmonary Edema Respiratory Tract Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0042063 BXGD002953 Urogenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085083 BXGD003120 Ovarian Hyperstimulation Syndrome Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085649 BXGD003222 Peripheral edema Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0086367 BXGD003276 Gonadotropin-Resistant Ovary Syndrome Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0149952 BXGD003393 Torsion of ovary Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151603 BXGD003445 Anasarca Pathological Conditions, Signs and Symptoms
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0154208 BXGD003707 Disorder of endocrine ovary Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0154723 BXGD003737 Migraine with Aura Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206081 BXGD004152 Hyperandrogenism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0206699 BXGD004249 Cystadenocarcinoma, Mucinous Neoplasms
C0206709 BXGD004257 Cystadenoma, Serous Neoplasms
C0206724 BXGD004269 Sex Cord-Stromal Tumor Neoplasms
C0206733 BXGD004278 Strawberry nevus of skin Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0220761 BXGD004339 Dizygotic twins (disorder)
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0232940 BXGD004569 Secondary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0233200 BXGD004572 Cullen's sign
C0241011 BXGD005073 Low serum estradiol levels
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0243066 BXGD005213 Atresia
C0262584 BXGD005256 Carcinoma, Small Cell Neoplasms
C0266371 BXGD005659 Streak ovary
C0266432 BXGD005667 Leydig cell agenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0271084 BXGD006159 Exudative age-related macular degeneration Eye Diseases
C0271791 BXGD006260 Severe hypothyroidism Endocrine System Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338078 BXGD007166 Non-Functioning Pituitary Gland Neoplasm Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0342510 BXGD007493 Ovarian dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0342543 BXGD007500 Central Precocious Puberty Endocrine System Diseases
C0342549 BXGD007504 Familial Testotoxicosis Endocrine System Diseases
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0346990 BXGD007842 Carcinomatosis of peritoneal cavity Digestive System Diseases; Neoplasms
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0404572 BXGD008322 Female infertility associated with anovulation Female Urogenital Diseases and Pregnancy Complications
C0425957 BXGD008555 Secondary amenorrhea Pathological Conditions, Signs and Symptoms
C0429468 BXGD008651 Anovulatory (finding) Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0432475 BXGD008794 XX males Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0473311 BXGD008937 Hemorrhagic cyst of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0520927 BXGD009124 Decreased fertility
C0521158 BXGD009130 Recurrent tumor
C0541764 BXGD009259 Delayed bone age
C0546884 BXGD009345 Hypovolemia Pathological Conditions, Signs and Symptoms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600113 BXGD009691 Stromal tumor of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685837 BXGD009819 Pure Gonadal Dysgenesis, 46, XX Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700502 BXGD009893 Acquired hypothyroidism Endocrine System Diseases
C0729353 BXGD009924 Subfertility Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0747102 BXGD010159 Ovarian failure Endocrine System Diseases
C0853662 BXGD010975 Oestrogen deficiency
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0855197 BXGD011079 Malignant Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0860158 BXGD011214 Leydig Cell Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948896 BXGD011563 Primary hypogonadism Endocrine System Diseases
C0949595 BXGD011580 Gonadal Dysgenesis, 46,XX Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1336708 BXGD012852 Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C1368683 BXGD012900 Epithelioma Neoplasms
C1382398 BXGD012934 Increased capillary permeability (finding)
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1611743 BXGD013456 Familial (FPAH)
C1658953 BXGD013486 tumor vasculature
C1832174 BXGD013807 DOYNE HONEYCOMB RETINAL DYSTROPHY Eye Diseases; Nervous System Diseases
C1850534 BXGD015149 Edema, generalized Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C1858573 BXGD015809 Sparse pubic hair
C1862265 BXGD016119 Increased circulating gonadotropin level Nervous System Diseases; Endocrine System Diseases
C1960447 BXGD016660 Hypergonadotropic amenorrhea
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2585739 BXGD017141 Hyperreactio luteinalis Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C2751898 BXGD017749 Ventricular Fibrillation, Paroxysmal Familial, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2986561 BXGD018230 Spindle Cell Oncocytoma of the Adenohypophysis Neoplasms
C3494162 BXGD018956 Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C3839507 BXGD019774 Diminished ovarian reserve Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4021107 BXGD020557 Non-obstructive azoospermia Male Urogenital Diseases
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4023911 BXGD021273 Aplasia/Hypoplasia of the breasts
C4024640 BXGD021354 Aplasia/hypoplasia of the uterus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4024641 BXGD021355 Enlarged polycystic ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4025170 BXGD021574 Osteoporosis of vertebrae
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4072885 BXGD022010 Increased serum testosterone level
C4316995 BXGD022715 Primary Hypothyroidism Endocrine System Diseases
C4317089 BXGD022721 Infantile hemangioma Neoplasms; Cardiovascular Diseases
C4521591 BXGD023064 Peripheral precocious puberty Endocrine System Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4554651 BXGD023568 Generalized Edema, CTCAE
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002379 N-Isobutyl-2,4,8,10,12-tetradecapentaenamide 273.41
BXGC0018397 beta-1,4-mannan 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein