Showing entry for Tripeptidyl-peptidase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004096
Protein NameTripeptidyl-peptidase 1
Uniport IdO14773
GeneTPP1
Gene Id1200
DomainPro-kuma_activ
Pfam PF09286  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0045453 bone resorption
Biological Process GO:0007417 central nervous system development
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0007040 lysosome organization
Biological Process GO:0007399 nervous system development
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0043171 peptide catabolic process
Biological Process GO:0030163 protein catabolic process
Biological Process GO:0070198 protein localization to chromosome, telomeric region
Biological Process GO:0006508 proteolysis
molecular function GO:0004175 endopeptidase activity
molecular function GO:0035727 lysophosphatidic acid binding
molecular function GO:0046872 metal ion binding
molecular function GO:0008233 peptidase activity
molecular function GO:0042277 peptide binding
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0008236 serine-type peptidase activity
molecular function GO:0120146 sulfatide binding
molecular function GO:0008240 tripeptidyl-peptidase activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005764 lysosome
cellular component GO:0042470 melanosome
cellular component GO:0045121 membrane raft
cellular component GO:0055037 recycling endosome
Reactome
Pathway Id Pathway Name
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004138 BXGD000258 Ataxias, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0004277 BXGD000266 Tooth Attrition Stomatognathic Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0022340 BXGD001536 Late-Infantile Neuronal Ceroid Lipfuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0022797 BXGD001586 Adult Neuronal Ceroid Lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027877 BXGD002055 Neuronal Ceroid-Lipofuscinoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0027888 BXGD002056 Hereditary Motor and Sensory Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030283 BXGD002200 Pancreatic Cyst Digestive System Diseases; Neoplasms
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034935 BXGD002497 Babinski Reflex
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0036391 BXGD002608 Schwartz-Jampel Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038325 BXGD002745 Stevens-Johnson Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0079680 BXGD003085 Lentivirus Infections Infections
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0162672 BXGD003972 MERRF Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0233844 BXGD004620 Clumsiness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0234162 BXGD004627 Cerebellar Dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234378 BXGD004661 Static Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0241210 BXGD005086 Speech Delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0241816 BXGD005115 Global brain atrophy
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265965 BXGD005592 Dyskeratosis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases
C0268274 BXGD005877 Gangliosidoses, GM2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268281 BXGD005882 Infantile neuronal ceroid lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268468 BXGD005957 Dystonia, Dopa-Responsive, due to Sepiapterin Reductase Deficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms
C0271270 BXGD006178 Oculovestibuloauditory syndrome Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0271385 BXGD006193 Horizontal Nystagmus Eye Diseases; Nervous System Diseases
C0272170 BXGD006312 Shwachman syndrome
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0278184 BXGD006506 Scanning speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0347959 BXGD007865 Lactic acidemia
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0423083 BXGD008469 Hypermetric saccades
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0546126 BXGD009328 Acute Confusional Senile Dementia Nervous System Diseases; Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678230 BXGD009750 Congenital Epicanthus
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0750900 BXGD010241 Alzheimer's Disease, Focal Onset Nervous System Diseases; Mental Disorders
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751383 BXGD010422 Juvenile Neuronal Ceroid Lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751783 BXGD010592 Lafora Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0856863 BXGD011122 Broad-based gait
C1148551 BXGD011766 X-Linked Dyskeratosis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1285498 BXGD012171 Vegetation
C1291230 BXGD012204 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1295585 BXGD012241 Decreased vibratory sense Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1334274 BXGD012695 Invasive Carcinoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1834207 BXGD013961 Ceroid Lipofuscinosis, Neuronal, Parry Type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1836392 BXGD014111 Dysmetric saccades
C1836474 BXGD014120 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1836479 BXGD014121 Saccadic smooth pursuit
C1836830 BXGD014165 Developmental regression Mental Disorders
C1836852 BXGD014169 Curvilinear intracellular accumulation of autofluorescent lipopigment storage material
C1839364 BXGD014371 Progressive visual loss
C1843885 BXGD014616 Progressive gait ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1846142 BXGD014785 HOYERAAL-HREIDARSSON SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Hemic and Lymphatic Diseases; Behavior and Behavior Mechanisms
C1850041 BXGD015098 Facial hirsutism
C1850451 BXGD015145 CEROID LIPOFUSCINOSIS, NEURONAL, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1851400 BXGD015210 Facial Hypertrichosis Skin and Connective Tissue Diseases
C1853241 BXGD015321 Flat face
C1854494 BXGD015409 Slow progression
C1855685 BXGD015531 Undetectable electroretinogram
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859828 BXGD015934 Increased extraneuronal autofluorescent lipopigment
C1876161 BXGD016555 CEROID LIPOFUSCINOSIS, NEURONAL, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3273225 BXGD018648 Hereditary Neurodegenerative Disorder Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3489733 BXGD018945 Oculomotor apraxia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C3541994 BXGD019100 Drug Hypersensitivity Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3896673 BXGD020041 Familial Nonmedullary Thyroid Gland Carcinoma
C4021219 BXGD020582 Multifocal epileptiform discharges
C4021727 BXGD020736 EMG: neuropathic changes
C4021781 BXGD020776 Abnormal nervous system electrophysiology
C4022738 BXGD020974 Neurodevelopmental delay
C4024710 BXGD021381 Cerebellar cortical atrophy
C4025728 BXGD021760 Increased neuronal autofluorescent lipopigment
C4025860 BXGD021833 Hearing abnormality
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551584 BXGD023362 Brain atrophy Nervous System Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein