Showing entry for Inhibitor of nuclear factor kappa-B kinase subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004126
Protein NameInhibitor of nuclear factor kappa-B kinase subunit alpha
Uniport IdO15111
GeneCHUK
Gene Id1147
DomainIKBKB_SDD; IKKbetaNEMObind; Pkinase
Pfam PF18397   PF12179   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01523 Antifolate resistance
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04620 Toll-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04622 RIG-I-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04623 Cytosolic DNA-sensing pathway
5. Organismal Systems 5.1 Immune system hsa04625 C-type lectin receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04657 IL-17 signaling pathway
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04668 TNF signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04920 Adipocytokine signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05142 Chagas disease (American trypanosomiasis)
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05212 Pancreatic cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05220 Chronic myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05221 Acute myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05222 Small cell lung cancer
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Biological Process GO:0071276 cellular response to cadmium ion
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0098586 cellular response to virus
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0007252 I-kappaB phosphorylation
Biological Process GO:0006955 immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0002756 MyD88-independent toll-like receptor signaling pathway
Biological Process GO:0032088 negative regulation of NF-kappaB transcription factor activity
Biological Process GO:0038061 NIK/NF-kappaB signaling
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0032727 positive regulation of interferon-alpha production
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0010034 response to acetate
Biological Process GO:0043200 response to amino acid
Biological Process GO:0061847 response to cholecystokinin
Biological Process GO:0042493 response to drug
Biological Process GO:0033194 response to hydroperoxide
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0009615 response to virus
Biological Process GO:0007266 Rho protein signal transduction
Biological Process GO:0003009 skeletal muscle contraction
Biological Process GO:0002223 stimulatory C-type lectin receptor signaling pathway
Biological Process GO:0051403 stress-activated MAPK cascade
Biological Process GO:0051146 striated muscle cell differentiation
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0035666 TRIF-dependent toll-like receptor signaling pathway
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0008384 IkappaB kinase activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0097110 scaffold protein binding
molecular function GO:1990459 transferrin receptor binding
cellular component GO:0035631 CD40 receptor complex
cellular component GO:0005737 cytoplasm
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0008385 IkappaB kinase complex
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-446652 Interleukin-1 family signaling
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450294 MAP kinase activation
R-HSA-5260271 Diseases of Immune System
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5602358 Diseases associated with the TLR signaling cascade
R-HSA-5602636 IKBKB deficiency causes SCID
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-73887 Death Receptor Signalling
R-HSA-75893 TNF signaling
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9020702 Interleukin-1 signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-937039 IRAK1 recruits IKK complex
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005941 BXGD000353 Bone Diseases, Developmental Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013575 BXGD000854 Ectodermal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0013949 BXGD000872 Embryopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015929 BXGD001024 Fetal Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026846 BXGD001939 Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030354 BXGD002214 Papilloma Neoplasms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0037268 BXGD002675 Skin Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043144 BXGD003032 Wheezing Pathological Conditions, Signs and Symptoms
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0086438 BXGD003283 Hypogammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152244 BXGD003571 Bone Cysts, Aneurysmal Neoplasms; Musculoskeletal Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206762 BXGD004290 Limb Deformities, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0241442 BXGD005099 Protrusion of tongue
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265259 BXGD005487 Popliteal pterygium syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Musculoskeletal Diseases; Male Urogenital Diseases; Stomatognathic Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0345371 BXGD007729 Hypoplasia of lower limb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0406709 BXGD008365 Hay-Wells syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C0423757 BXGD008504 Thin skin
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685776 BXGD009816 Congenital absence of mandible
C0702139 BXGD009909 Congenital absence of external ear Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0795690 BXGD010728 Congenital omphalocele Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1629609 BXGD013479 Age at menopause
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1837406 BXGD014230 Hypoplasia involving bones of the upper limbs
C1848869 BXGD014980 Absent external genitalia
C1849718 BXGD015080 POPLITEAL PTERYGIUM SYNDROME, LETHAL TYPE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C1851585 BXGD015222 MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA Hemic and Lymphatic Diseases
C1851841 BXGD015242 ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C2118460 BXGD016927 Acute colitis Digestive System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2677485 BXGD017375 Aplasia of the sweat glands
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3150891 BXGD018347 COCOON SYNDROME
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3642345 BXGD019244 Luminal A Breast Carcinoma
C3714514 BXGD019409 Infection Infections
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004115 Norharman 168.19
BXGC0005625 alpha-D-Glucopyranose 180.16
BXGC0012352 Chelerythrine 348.12
BXGC0014682 Bergenin 328.08
BXGC0025362 Peperomin E 412.12
BXGC0028696 Cichoric Acid 474.08
BXGC0033112 Acetylcysteine 163.03
BXGC0037002 Eurycomalactone 348.16
BXGC0040462 Aminosalicylic Acid 153.04
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0049832 isosclerone 178.06
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein