Showing entry for Cyclic AMP-dependent transcription factor ATF-6 alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008433
Protein NameCyclic AMP-dependent transcription factor ATF-6 alpha
Uniport IdP18850
GeneATF6
Gene Id22926
DomainbZIP_1
Pfam PF00170  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0036500 ATF6-mediated unfolded protein response
Biological Process GO:0030968 endoplasmic reticulum unfolded protein response
Biological Process GO:0001654 eye development
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:1903893 positive regulation of ATF6-mediated unfolded protein response
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Biological Process GO:0006457 protein folding
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0007165 signal transduction
Biological Process GO:0007601 visual perception
molecular function GO:0035497 cAMP response element binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0042802 identical protein binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0030176 integral component of endoplasmic reticulum membrane
cellular component GO:0016020 membrane
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005635 nuclear envelope
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones
R-HSA-381042 PERK regulates gene expression
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003949 BXGD000242 Asbestosis Respiratory Tract Diseases; Occupational Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008149 BXGD000520 Chlamydia Infections Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0008677 BXGD000560 Bronchitis, Chronic Infections; Respiratory Tract Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009398 BXGD000604 Color vision defect Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0011303 BXGD000712 Demyelinating Diseases Nervous System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0015310 BXGD000976 Exotropia Eye Diseases; Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015696 BXGD001014 Fatty Liver, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0021192 BXGD001490 Indeterminate leprosy Infections; Skin and Connective Tissue Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0023348 BXGD001636 Leprosy, Lepromatous Infections
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023827 BXGD001707 liposarcoma Neoplasms
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035869 BXGD002569 Rotavirus Infections Infections
C0036457 BXGD002617 Scrapie Infections; Nervous System Diseases; Animal Diseases
C0036646 BXGD002627 Age-related cataract Eye Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152191 BXGD003556 Scotoma, Central Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152200 BXGD003557 Achromatopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0155015 BXGD003764 Color Blindness, Red Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0155016 BXGD003765 Color Blindness, Red-Green Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0155017 BXGD003766 Color Blindness, Blue Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0155018 BXGD003767 Color Blindness, Acquired Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221757 BXGD004472 alpha 1-Antitrypsin Deficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239777 BXGD004991 Color Blindness, Green Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0242225 BXGD005143 Color blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0243066 BXGD005213 Atresia
C0265290 BXGD005503 Metaphyseal chondrodysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0271388 BXGD006196 Pendular Nystagmus Eye Diseases; Nervous System Diseases
C0276447 BXGD006425 Rhinovirus infection Infections
C0278608 BXGD006549 Adult Liposarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279984 BXGD006703 Childhood Liposarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302129 BXGD006830 Achromatopsia 1 Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0334276 BXGD007016 Adenocarcinoma in Situ Pathological Conditions, Signs and Symptoms; Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339537 BXGD007264 Cone monochromatism Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376329 BXGD007989 New Variant Creutzfeldt-Jakob Disease Infections; Nervous System Diseases; Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423420 BXGD008483 Absent foveal reflex
C0423421 BXGD008484 Atrophic macular change
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0543968 BXGD009303 Cone dysfunction syndrome
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0700501 BXGD009892 Congenital nystagmus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0730292 BXGD009947 Macular dystrophy Eye Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751042 BXGD010303 Color Blindness, Inherited Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0751043 BXGD010304 Monochromatopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751254 BXGD010366 Creutzfeldt-Jakob Disease, Familial Infections; Nervous System Diseases; Mental Disorders
C0751713 BXGD010564 Inclusion Body Myopathy, Sporadic Musculoskeletal Diseases; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0858618 BXGD011184 Dyschromatopsia
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1274795 BXGD012046 Urban Schosser Spohn syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1301034 BXGD012282 Pancreatic intraepithelial neoplasia Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1840457 BXGD014472 Retinal pigment epithelial atrophy
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1969372 BXGD016775 Tubulointerstitial fibrosis
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2673946 BXGD017234 Foveal hypoplasia (finding)
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2930617 BXGD017888 Pulmonary Fibrosis - from Asbestos Exposure Respiratory Tract Diseases; Occupational Diseases
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3272820 BXGD018634 Ulcerative Colitis-Associated Colorectal Adenocarcinoma
C3278975 BXGD018749 Attenuation of retinal blood vessels
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3887971 BXGD019935 RETINAL DYSPLASIA, PRIMARY
C4021796 BXGD020786 Renal steatosis
C4024799 BXGD021424 Granular macular appearance
C4225297 BXGD022213 ACHROMATOPSIA 7
C4529962 BXGD023178 Fatty Liver Disease
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4684870 BXGD023575 Refractory Osteosarcoma Neoplasms
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018772 Pseudoephedrine 165.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein