protein

Showing entry for Myeloid cell surface antigen CD33

General Target Information
BXGT Id	BXGT023857
Protein Name	Myeloid cell surface antigen CD33
Uniport Id	P20138
Gene	CD33
Gene Id	945
Domain	ig; V-set
Pfam	PF00047 PF07686
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.1 Immune system	hsa04640	Hematopoietic cell lineage

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0007267	cell-cell signaling
Biological Process	GO:0002765	immune response-inhibiting signal transduction
Biological Process	GO:0051926	negative regulation of calcium ion transport
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production
Biological Process	GO:0032717	negative regulation of interleukin-8 production
Biological Process	GO:0150102	negative regulation of monocyte activation
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production
Biological Process	GO:0043312	neutrophil degranulation
Biological Process	GO:0050714	positive regulation of protein secretion
Biological Process	GO:1903615	positive regulation of protein tyrosine phosphatase activity
Biological Process	GO:0050776	regulation of immune response
Biological Process	GO:0007165	signal transduction
molecular function	GO:0030246	carbohydrate binding
molecular function	GO:0019903	protein phosphatase binding
molecular function	GO:0033691	sialic acid binding
molecular function	GO:0038023	signaling receptor activity
cellular component	GO:0009986	cell surface
cellular component	GO:0009897	external side of plasma membrane
cellular component	GO:0005794	Golgi apparatus
cellular component	GO:0005887	integral component of plasma membrane
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0005777	peroxisome
cellular component	GO:0005886	plasma membrane
cellular component	GO:0035579	specific granule membrane
cellular component	GO:0070821	tertiary granule membrane

Reactome

Pathway Id	Pathway Name
R-HSA-1280218	Adaptive Immune System
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695	Neutrophil degranulation

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002726	BXGD000125	Amyloidosis	Nutritional and Metabolic Diseases
C0002792	BXGD000129	anaphylaxis	Immune System Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0005699	BXGD000325	Blast Phase	Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007124	BXGD000437	Noninfiltrating Intraductal Carcinoma	Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0008626	BXGD000559	Congenital chromosomal disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0011265	BXGD000708	Presenile dementia	Nervous System Diseases; Mental Disorders
C0011311	BXGD000714	Dengue Fever	Infections
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013467	BXGD000844	East Coast Fever	Infections; Animal Diseases
C0014060	BXGD000882	Encephalitis, St. Louis	Infections; Nervous System Diseases
C0014518	BXGD000921	Toxic Epidermal Necrolysis	Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C0015625	BXGD001006	Fanconi Anemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0018133	BXGD001176	Graft-vs-Host Disease	Immune System Diseases
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0021051	BXGD001475	Immunologic Deficiency Syndromes	Immune System Diseases
C0023418	BXGD001642	leukemia	Neoplasms
C0023434	BXGD001643	Chronic Lymphocytic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449	BXGD001650	Acute lymphocytic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452	BXGD001651	Childhood Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023461	BXGD001653	Leukemia, Mast-Cell	Neoplasms
C0023464	BXGD001655	Acute biphenotypic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465	BXGD001656	Acute monocytic leukemia	Neoplasms
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0023470	BXGD001659	Myeloid Leukemia	Neoplasms
C0023473	BXGD001661	Myeloid Leukemia, Chronic	Neoplasms; Hemic and Lymphatic Diseases
C0023485	BXGD001667	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023487	BXGD001669	Acute Promyelocytic Leukemia	Neoplasms
C0023508	BXGD001675	White Blood Cell Count procedure
C0023530	BXGD001683	Leukopenia	Hemic and Lymphatic Diseases
C0024117	BXGD001734	Chronic Obstructive Airway Disease	Respiratory Tract Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0024232	BXGD001751	Lymphatic Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0024299	BXGD001758	Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305	BXGD001763	Lymphoma, Non-Hodgkin	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0025286	BXGD001850	Meningioma	Neoplasms; Nervous System Diseases
C0026499	BXGD001905	Monosomy	Pathological Conditions, Signs and Symptoms
C0026764	BXGD001928	Multiple Myeloma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026998	BXGD001959	Acute Myeloid Leukemia, M1	Neoplasms
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032463	BXGD002357	Polycythemia Vera	Neoplasms; Hemic and Lymphatic Diseases
C0079731	BXGD003087	B-Cell Lymphomas	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085669	BXGD003233	Acute leukemia	Pathological Conditions, Signs and Symptoms; Neoplasms
C0152276	BXGD003581	Granulocytic Sarcoma	Neoplasms
C0202236	BXGD004086	Triglycerides measurement
C0206754	BXGD004289	Neuroendocrine Tumors	Neoplasms
C0220605	BXGD004294	Adult Non-Hodgkin Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612	BXGD004296	Childhood Non-Hodgkin Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220615	BXGD004298	Adult Acute Myeloblastic Leukemia	Neoplasms
C0220621	BXGD004300	Childhood Acute Myeloid Leukemia	Neoplasms
C0221013	BXGD004363	Mastocytosis, Systemic	Neoplasms; Immune System Diseases
C0234985	BXGD004708	Mental deterioration	Mental Disorders
C0235946	BXGD004789	Cerebral atrophy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0242596	BXGD005181	Neoplasm, Residual	Pathological Conditions, Signs and Symptoms; Neoplasms
C0265219	BXGD005468	Miller Dieker syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270823	BXGD006112	Petit mal status	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0275524	BXGD006376	Coinfection	Infections
C0276496	BXGD006426	Familial Alzheimer Disease (FAD)	Nervous System Diseases; Mental Disorders
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0279583	BXGD006640	Childhood T Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279592	BXGD006643	Adult T Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0280217	BXGD006720	stage, non-small cell lung cancer	Neoplasms; Respiratory Tract Diseases
C0280313	BXGD006737	Squamous cell carcinoma of oropharynx	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0340970	BXGD007379	Congenital neutropenia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0427460	BXGD008616	Red cell distribution width determination
C0474855	BXGD008963	Compound leukemias	Neoplasms
C0494463	BXGD009029	Alzheimer Disease, Late Onset	Nervous System Diseases; Mental Disorders
C0524851	BXGD009246	Neurodegenerative Disorders	Nervous System Diseases
C0546126	BXGD009328	Acute Confusional Senile Dementia	Nervous System Diseases; Mental Disorders
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0677886	BXGD009734	Epithelial ovarian cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0750900	BXGD010241	Alzheimer's Disease, Focal Onset	Nervous System Diseases; Mental Disorders
C0750901	BXGD010242	Alzheimer Disease, Early Onset	Nervous System Diseases; Mental Disorders
C0751606	BXGD010523	Adult Acute Lymphocytic Leukemia
C0878500	BXGD011365	Intraepithelial Neoplasia	Neoplasms
C1168401	BXGD011792	Squamous cell carcinoma of the head and neck	Neoplasms
C1269955	BXGD012005	Tumor Cell Invasion
C1270972	BXGD012006	Mild cognitive disorder	Mental Disorders
C1274310	BXGD012030	Primary cutaneous B-cell lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1292758	BXGD012229	Precursor T-cell lymphoblastic lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1292769	BXGD012230	Precursor B-cell lymphoblastic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1292778	BXGD012237	Chronic myeloproliferative disorder	Neoplasms; Hemic and Lymphatic Diseases
C1304746	BXGD012343	RDW - Red blood cell distribution width result
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1332206	BXGD012504	Adult Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332213	BXGD012507	Adult T Lymphoblastic Lymphoma
C1332977	BXGD012569	Childhood Leukemia	Neoplasms
C1332979	BXGD012571	Childhood Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332998	BXGD012577	Childhood T Lymphoblastic Lymphoma
C1456868	BXGD013128	Diabetic foot ulcer	Skin and Connective Tissue Diseases; Endocrine System Diseases; Cardiovascular Diseases
C1519653	BXGD013238	Trisomy 4	Pathological Conditions, Signs and Symptoms
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1709527	BXGD013626	B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
C1739395	BXGD013739	Takotsubo Cardiomyopathy	Cardiovascular Diseases
C1840264	BXGD014439	IMMUNE SUPPRESSION
C1853118	BXGD015302	Severe congenital neutropenia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1879321	BXGD016572	Acute Myeloid Leukemia (AML-M2)	Neoplasms
C1883018	BXGD016594	Severe Aplastic Anemia	Hemic and Lymphatic Diseases
C1955906	BXGD016613	Lymphoma, Extranodal NK-T-Cell	Neoplasms
C1961099	BXGD016672	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1961102	BXGD016673	Precursor Cell Lymphoblastic Leukemia Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2004493	BXGD016875	Leukemia, B-Cell	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2825139	BXGD017770	Acute Myeloid Leukemia with Myelodysplasia-Related Changes	Neoplasms
C2985280	BXGD018223	Blood Protein Measurement
C3463824	BXGD018899	MYELODYSPLASTIC SYNDROME	Hemic and Lymphatic Diseases
C3469521	BXGD018910	FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3714514	BXGD019409	Infection	Infections
C3839741	BXGD019782	Core binding factor acute myeloid leukemia	Neoplasms
C3888194	BXGD019955	MIXED LINEAGE LEUKEMIA
C3896960	BXGD020042	Childhood Pre-B Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C3896961	BXGD020043	Adult Pre-B Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4048329	BXGD021904	Immunosuppression
C4288891	BXGD022486	Infant T Acute Lymphoblastic Leukemia
C4528668	BXGD023176	Acute myeloid leukaemia refractory	Neoplasms
C4551584	BXGD023362	Brain atrophy	Nervous System Diseases
C4721532	BXGD023752	Lymphoma, Non-Hodgkin, Familial	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}