Showing entry for Paclitaxel


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0027421
Compound NamePaclitaxel
Structure
FormulaC47H51NO14
InchiKeyRCINICONZNJXQF-MZXODVADSA-N
SMILESCC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@@H]3[C@]([C@H]2[C@@H]([C@]2(C(C1=C(C)[C@@H](OC(=O)[C@@H]([C@H](c1ccccc1)N=C(c1ccccc1)O)O)C2)(C)C)O)OC(=O)c1ccccc1)(CO3)OC(=O)C
InchiInChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24
IUPAC
Molecular Weight853.33
Pubchem Id36314
Chembl IdCHEMBL428647
Targets of Information Source
DrugBank DB01229
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 approved; vet_approved inhibitor
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 approved; vet_approved inhibitor
P27816 BXGT009209 Microtubule-associated protein 4 reviewed - MAP4 approved; vet_approved -
P11137 BXGT007656 Microtubule-associated protein 2 reviewed - MAP2 approved; vet_approved -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT approved; vet_approved -
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 approved; vet_approved inducer
PDB TA1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed TUBB2B - - - - -
P02554 BXGT005892 Tubulin beta chain reviewed - - - - -
P02557 BXGT005893 Tubulin beta chain reviewed TUB2 - - - - -
P07437 BXGT006624 Tubulin beta chain reviewed TUBB Cellular structure - - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed ABCB1 Transporter - - - -
Binding DB 50001839
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009161 Serum paraoxonase/arylesterase 1 reviewed PON1 16500 42000 - -
reviewed BXGT008651 ATP-dependent translocase ABCB1 reviewed Abcb1a - 327000 - -
reviewed BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed UGT1A1 - 20000 - -
reviewed BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed UGT1A4 - 4900 - -
reviewed BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed UGT1A6 - 74000 - -
reviewed BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed UGT2B7 - >3.00e+5 - -
reviewed BXGT009924 UDP-glucuronosyltransferase 2B10 reviewed UGT2B10 - >3.00e+5 - -
reviewed BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC - >10000 - -
reviewed BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR - >10000 - -
reviewed BXGT007693 Fibroblast growth factor receptor 1 reviewed Kinase FGFR1 - >10000 - -
reviewed BXGT005570 Tyrosine-protein kinase ABL1 reviewed Kinase ABL1 - >10000 - -
reviewed BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 - 280 - -
reviewed BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 - 260 - -
reviewed BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 1800 - - -
reviewed BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 840 - - -
reviewed BXGT013273 Tyrosine-protein kinase Mer reviewed Kinase MERTK - 4900 - -
reviewed BXGT006315 Integrin beta-3 reviewed Receptor ITGB3 - 34 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 53900 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 54000 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 70200 - -
reviewed BXGT005373 Bile salt export pump reviewed Transporter ABCB11 - 26800 - -
reviewed BXGT005373 Bile salt export pump reviewed Transporter ABCB11 - 28900 - -
reviewed BXGT007528 Botulinum neurotoxin type A reviewed botA - 5200 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 2596 - -
CHEMBL CHEMBL428647
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q862F3 BXGT017581 Similar to alpha-tubulin isoform 1 unreviewed - Inhibition '=' 20 %
Q862L2 BXGT017582 Similar to alpha-tubulin isoform 1 unreviewed - Inhibition '=' 20 %
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B Inhibition '=' 20 %
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A ED50 ratio '=' 1 -
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 12589 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 53 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 510 nM
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Activity '=' 6 %
P02554 BXGT005892 Tubulin beta chain reviewed - Activity '=' 6 %
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 3981 nM
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 39810 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 183 nM
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Activity '=' 66 %
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Inhibition - - -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Inhibition - - -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Inhibition - - -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Inhibition - - -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Inhibition - - -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Inhibition - - -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Inhibition - - -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Inhibition - - -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Inhibition - - -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Inhibition - - -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Inhibition - - -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Inhibition - - -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Inhibition - - -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Inhibition - - -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Inhibition - - -
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Activity - - -
P02554 BXGT005892 Tubulin beta chain reviewed - Activity - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 2310 nM
Q862F3 BXGT017581 Similar to alpha-tubulin isoform 1 unreviewed - Activity - - -
Q862L2 BXGT017582 Similar to alpha-tubulin isoform 1 unreviewed - Activity - - -
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B Activity - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 '=' 23906 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18 nM
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Activity '=' 23 %
P02554 BXGT005892 Tubulin beta chain reviewed - Activity '=' 23 %
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 25118 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Activity - - -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Activity - - -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Activity - - -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Activity - - -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Activity - - -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Activity - - -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Activity - - -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Activity - - -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Activity - - -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Activity - - -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Activity - - -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Activity - - -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Activity - - -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Activity - - -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Activity - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki '=' 1481 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 '=' 17133 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 IC50 '=' 9 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_Papp '>' 108 -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P21447 BXGT008651 ATP-dependent translocase ABCB1 reviewed - Abcb1a Activity - - -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 10000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 12 %
P02554 BXGT005892 Tubulin beta chain reviewed - Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 53900 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 44668 nM
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC IC50 '>' 10000 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Activity - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 2592 nM
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 12589 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 7 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 71 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 % maximum response '=' 0 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 22 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 70200 nM
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 17782 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 44668 nM
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki '=' 16072 nM
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B GTPase Activity '=' 3 -
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 5623 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 1 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 51 nM
Q862F3 BXGT017581 Similar to alpha-tubulin isoform 1 unreviewed - Ratio '=' 1 -
Q862L2 BXGT017582 Similar to alpha-tubulin isoform 1 unreviewed - Ratio '=' 1 -
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B Ratio '=' 1 -
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Tubulin polymerization '=' 1 -
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 EC50 '=' 31 nM
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B EC50 '=' 31 nM
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A EC50 '=' 31 nM
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E EC50 '=' 31 nM
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C EC50 '=' 31 nM
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B EC50 '=' 31 nM
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB EC50 '=' 31 nM
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 EC50 '=' 31 nM
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A EC50 '=' 31 nM
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A EC50 '=' 31 nM
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 EC50 '=' 31 nM
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A EC50 '=' 31 nM
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C EC50 '=' 31 nM
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 EC50 '=' 31 nM
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B EC50 '=' 31 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki '=' 2276 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 '=' 11380 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 19952 nM
Q9QY30 BXGT021389 Bile salt export pump reviewed - Abcb11 Activity - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 1258 nM
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Activity '=' 32 %
P02554 BXGT005892 Tubulin beta chain reviewed - Activity '=' 32 %
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 ED50 '=' 0 uM
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B ED50 '=' 0 uM
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A ED50 '=' 0 uM
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E ED50 '=' 0 uM
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C ED50 '=' 0 uM
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B ED50 '=' 0 uM
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB ED50 '=' 0 uM
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 ED50 '=' 0 uM
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A ED50 '=' 0 uM
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A ED50 '=' 0 uM
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 ED50 '=' 0 uM
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A ED50 '=' 0 uM
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C ED50 '=' 0 uM
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 ED50 '=' 0 uM
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B ED50 '=' 0 uM
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
Q25270 BXGT013897 Beta-tubulin unreviewed - beta-tubulin Inhibition '=' 80 %
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 28900 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 44668 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 GI50 '>' 10000 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 35 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 14125 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Ratio ED50 '=' 1 -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Ratio ED50 '=' 1 -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Ratio ED50 '=' 1 -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Ratio ED50 '=' 1 -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Ratio ED50 '=' 1 -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Ratio ED50 '=' 1 -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Ratio ED50 '=' 1 -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Ratio ED50 '=' 1 -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Ratio ED50 '=' 1 -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Ratio ED50 '=' 1 -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Ratio ED50 '=' 1 -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Ratio ED50 '=' 1 -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Ratio ED50 '=' 1 -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Ratio ED50 '=' 1 -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Ratio ED50 '=' 1 -
A3EZI9 BXGT001153 Genome polyprotein unreviewed - NS3 IC50 '>' 1000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 5956 nM
Q862F3 BXGT017581 Similar to alpha-tubulin isoform 1 unreviewed - EC50 '=' 830 nM
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B EC50 '=' 830 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 15848 nM
Q25270 BXGT013897 Beta-tubulin unreviewed - beta-tubulin IC50 '<' 1000 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 223 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 18 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '<' 1 nm/s
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 '=' 11108 nM
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 '=' 6125 nM
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P21439 BXGT008649 Phosphatidylcholine translocator ABCB4 reviewed Transporter ABCB4 Activity - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 70794 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 94 %
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 87 %
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 1122 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Inhibition - - -
P00519 BXGT005570 Tyrosine-protein kinase ABL1 reviewed Kinase ABL1 IC50 '>' 10000 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 316 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 89 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 5 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 16360 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 2600 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 22387 nM
P0DPI0 BXGT007528 Botulinum neurotoxin type A reviewed - botA Activity '=' 7 %
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 GI50 '>' 10000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 2596 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 6309 nM
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A ED50 '=' 0 uM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 2238 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 15848 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 12589 nM
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A TIME '=' 0 hr
P02554 BXGT005892 Tubulin beta chain reviewed - TIME '=' 0 hr
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 54000 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 10000 nM
Q25270 BXGT013897 Beta-tubulin unreviewed - beta-tubulin Inhibition - - -
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 IC50 - - -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B IC50 - - -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A IC50 - - -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E IC50 - - -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C IC50 - - -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B IC50 - - -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB IC50 - - -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 IC50 - - -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A IC50 - - -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A IC50 - - -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 IC50 - - -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A IC50 - - -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C IC50 - - -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 IC50 - - -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B IC50 - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 16 %
Q862F3 BXGT017581 Similar to alpha-tubulin isoform 1 unreviewed - ED50 '=' 0 uM
Q862L2 BXGT017582 Similar to alpha-tubulin isoform 1 unreviewed - ED50 '=' 0 uM
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B ED50 '=' 0 uM
P06756 BXGT006499 Integrin alpha-V reviewed - ITGAV IC50 '=' 34 nM
P05106 BXGT006315 Integrin beta-3 reviewed Receptor ITGB3 IC50 '=' 34 nM
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B GTPase Activity '=' 1 -
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Concentration '=' 10 uM
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 29 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 35481 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 37685 nM
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 '>' 10000 nM
P0DPI0 BXGT007528 Botulinum neurotoxin type A reviewed - botA Inhibition '=' 85 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 21 nM
O95235 BXGT005360 Kinesin-like protein KIF20A reviewed Cellular structure KIF20A Imax - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 7943 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A EC50 '=' 520 nM
P02554 BXGT005892 Tubulin beta chain reviewed - EC50 '=' 520 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 5 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
Q5T3U5 BXGT015846 Multidrug resistance-associated protein 7 reviewed Transporter ABCC10 Activity '=' 22 %
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 IC50 '=' 260 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 168 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Vmax '=' 35 uM
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Ratio '=' 1 -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 58 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 ID50 ratio '=' 0 -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B ID50 ratio '=' 0 -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A ID50 ratio '=' 0 -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E ID50 ratio '=' 0 -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C ID50 ratio '=' 0 -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B ID50 ratio '=' 0 -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB ID50 ratio '=' 0 -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 ID50 ratio '=' 0 -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A ID50 ratio '=' 0 -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A ID50 ratio '=' 0 -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 ID50 ratio '=' 0 -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A ID50 ratio '=' 0 -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C ID50 ratio '=' 0 -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 ID50 ratio '=' 0 -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B ID50 ratio '=' 0 -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 ED50 ratio '=' 1 -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Activity - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio '=' 50 -
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Initial rate ratio '=' 1 -
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 8492 nM
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A ED50 '=' 0 uM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Log 1/ratio '=' 0 -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Log 1/ratio '=' 0 -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Log 1/ratio '=' 0 -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Log 1/ratio '=' 0 -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Log 1/ratio '=' 0 -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Log 1/ratio '=' 0 -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Log 1/ratio '=' 0 -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Log 1/ratio '=' 0 -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Log 1/ratio '=' 0 -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Log 1/ratio '=' 0 -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Log 1/ratio '=' 0 -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Log 1/ratio '=' 0 -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Log 1/ratio '=' 0 -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Log 1/ratio '=' 0 -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Log 1/ratio '=' 0 -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 17 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Log 1/ratio '=' 0 -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Log 1/ratio '=' 0 -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Log 1/ratio '=' 0 -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Log 1/ratio '=' 0 -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Log 1/ratio '=' 0 -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Log 1/ratio '=' 0 -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Log 1/ratio '=' 0 -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Log 1/ratio '=' 0 -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Log 1/ratio '=' 0 -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Log 1/ratio '=' 0 -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Log 1/ratio '=' 0 -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Log 1/ratio '=' 0 -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Log 1/ratio '=' 0 -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Log 1/ratio '=' 0 -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Log 1/ratio '=' 0 -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 65 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Log 1/Km '=' -1 -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 63 nM
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Activity '=' 100 %
P02554 BXGT005892 Tubulin beta chain reviewed - Activity '=' 100 %
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse IC50 '>' 200 ug.mL-1
P02550 BXGT005891 Tubulin alpha-1A chain reviewed - TUBA1A Binding ratio '=' 1 -
P02554 BXGT005892 Tubulin beta chain reviewed - Binding ratio '=' 1 -
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 47 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P21398 BXGT008645 Amine oxidase [flavin-containing] A reviewed - MAOA Activity - - -
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency '=' 15848 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 11220 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 22387 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 707 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 26800 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Km '=' 16500 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 31622 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 ID50 ratio '=' 1 -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B ID50 ratio '=' 1 -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A ID50 ratio '=' 1 -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E ID50 ratio '=' 1 -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C ID50 ratio '=' 1 -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B ID50 ratio '=' 1 -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB ID50 ratio '=' 1 -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 ID50 ratio '=' 1 -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A ID50 ratio '=' 1 -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A ID50 ratio '=' 1 -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 ID50 ratio '=' 1 -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A ID50 ratio '=' 1 -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C ID50 ratio '=' 1 -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 ID50 ratio '=' 1 -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B ID50 ratio '=' 1 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 1258 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Km '=' 700 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 9 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 25118 nM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 3548 nM
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 12589 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Inhibition '=' 7 %
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 562 nM
P0DPI0 BXGT007528 Botulinum neurotoxin type A reviewed - botA Activity - - -
Q12866 BXGT013273 Tyrosine-protein kinase Mer reviewed Kinase MERTK IC50 '=' 4900 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 28183 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 31622 nM
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 IC50 '=' 7 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 89125 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Activity '=' 99 %
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Activity '=' 99 %
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Activity '=' 99 %
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Activity '=' 99 %
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Activity '=' 99 %
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Activity '=' 99 %
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Activity '=' 99 %
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Activity '=' 99 %
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Activity '=' 99 %
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Activity '=' 99 %
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Activity '=' 99 %
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Activity '=' 99 %
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Activity '=' 99 %
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Activity '=' 99 %
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Activity '=' 99 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 4466 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 4466 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 '=' 4202 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 369 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 251 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 58 nM
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 52 %
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 37933 nM
Q862F3 BXGT017581 Similar to alpha-tubulin isoform 1 unreviewed - Activity '=' 4 uM
Q862L2 BXGT017582 Similar to alpha-tubulin isoform 1 unreviewed - Activity '=' 4 uM
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B Activity '=' 4 uM
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 3548 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 130 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Km '=' 14 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 7943 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 3 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_ATPase activity '=' 2 -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 14125 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 135 nm/s
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 29620 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 44668 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 62 %
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 12589 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Activity '=' 245 %
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Activity '=' 245 %
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Activity '=' 245 %
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Activity '=' 245 %
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Activity '=' 245 %
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Activity '=' 245 %
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Activity '=' 245 %
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Activity '=' 245 %
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Activity '=' 245 %
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Activity '=' 245 %
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Activity '=' 245 %
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Activity '=' 245 %
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Activity '=' 245 %
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Activity '=' 245 %
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Activity '=' 245 %
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Inhibition '=' 157 %
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Inhibition '=' 157 %
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Inhibition '=' 157 %
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Inhibition '=' 157 %
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Inhibition '=' 157 %
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Inhibition '=' 157 %
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Inhibition '=' 157 %
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Inhibition '=' 157 %
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Inhibition '=' 157 %
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Inhibition '=' 157 %
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Inhibition '=' 157 %
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Inhibition '=' 157 %
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Inhibition '=' 157 %
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Inhibition '=' 157 %
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Inhibition '=' 157 %
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki '=' 2042 nM
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P11362 BXGT007693 Fibroblast growth factor receptor 1 reviewed Kinase FGFR1 IC50 '>' 10000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 8 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 2 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 IC50 '=' 280 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 5011 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 2511 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 50118 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 44668 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 5011 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 EC50 '=' 1230 nM
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B EC50 '=' 1230 nM
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A EC50 '=' 1230 nM
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E EC50 '=' 1230 nM
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C EC50 '=' 1230 nM
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B EC50 '=' 1230 nM
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB EC50 '=' 1230 nM
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 EC50 '=' 1230 nM
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A EC50 '=' 1230 nM
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A EC50 '=' 1230 nM
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 EC50 '=' 1230 nM
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A EC50 '=' 1230 nM
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C EC50 '=' 1230 nM
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 EC50 '=' 1230 nM
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B EC50 '=' 1230 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' -2 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 7 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 21 nM
Q862F3 BXGT017581 Similar to alpha-tubulin isoform 1 unreviewed - Inhibition - - -
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed - TUBB2B Inhibition - - -
O95235 BXGT005360 Kinesin-like protein KIF20A reviewed Cellular structure KIF20A IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Ki '=' 1800 nM
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 141 nM
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' 30 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Activity - - -
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 28183 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 15000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 16 %
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Ki '=' 840 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 4228 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 24400 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 133000 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 ED90 '=' 0 uM
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B ED90 '=' 0 uM
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A ED90 '=' 0 uM
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E ED90 '=' 0 uM
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C ED90 '=' 0 uM
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B ED90 '=' 0 uM
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB ED90 '=' 0 uM
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 ED90 '=' 0 uM
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A ED90 '=' 0 uM
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A ED90 '=' 0 uM
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 ED90 '=' 0 uM
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A ED90 '=' 0 uM
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C ED90 '=' 0 uM
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 ED90 '=' 0 uM
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B ED90 '=' 0 uM
P10632 BXGT007592 Cytochrome P450 2C8 reviewed - CYP2C8 Activity - - -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 50 nM
Q9HC29 BXGT020526 Nucleotide-binding oligomerization domain-containing protein 2 reviewed Enzyme NOD2 IC50 '=' 7943 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9 nM
P0DPI0 BXGT007528 Botulinum neurotoxin type A reviewed - botA IC50 '=' 5200 nM
P09652 BXGT026140 Tubulin beta-4 chain reviewed - Inhibition '=' 98 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00151 Pomegranate Punica granatum Fruits
BXGF02479 Torreya nuncifera Torreya nuncifera Others
BXGF02574 Torreya grandis Torreya grandis Medicinal Plant
BXGF03695 Taxus wallichiana Taxus wallichiana Medicinal Plant
BXGF03696 Taxus mairei Taxus mairei Others
BXGF03896 Taxus cuspidata Taxus cuspidata Medicinal Plant
BXGF04369 Taxus brevifolia Taxus brevifolia Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease