Showing entry for Steroid hormone receptor ERR1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007710
Protein NameSteroid hormone receptor ERR1
Uniport IdP11474
GeneESRRA
Gene Id2101
DomainHormone_recep; zf-C4
Pfam PF00104   PF00105  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051216 cartilage development
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:1900078 positive regulation of cellular response to insulin stimulus
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0045667 regulation of osteoblast differentiation
Biological Process GO:0045670 regulation of osteoclast differentiation
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0032355 response to estradiol
Biological Process GO:0006367 transcription initiation from RNA polymerase II promoter
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:0019904 protein domain specific binding
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0005496 steroid binding
molecular function GO:0003707 steroid hormone receptor activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0001650 fibrillar center
cellular component GO:0045171 intercellular bridge
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8939902 Regulation of RUNX2 expression and activity
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001618 BXGD000063 Tumors of Adrenal Cortex Neoplasms; Endocrine System Diseases
C0002152 BXGD000104 Alloxan Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008354 BXGD000533 Cholera Infections
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013473 BXGD000845 Eating Disorders Mental Disorders
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0031036 BXGD002273 Polyarteritis Nodosa Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038433 BXGD002754 Streptozotocin Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280220 BXGD006722 stage, ovarian epithelial cancer
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1334177 BXGD012684 Infiltrating Cervical Carcinoma
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1827293 BXGD013768 Carcinoma of urinary bladder, invasive Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1862382 BXGD016125 SVEINSSON CHORIORETINAL ATROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2748055 BXGD017583 Hypoinsulinaemia (disorder)
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3887654 BXGD019912 POLYARTERITIS NODOSA, CHILDHOOD-ONSET Skin and Connective Tissue Diseases; Cardiovascular Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4264446 BXGD022316 Mixed carcinoma
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000340 Kaempferol 286.24
BXGC0003707 Estrogen 268.36
BXGC0003776 Flavones 222.24
BXGC0005624 Genistein 270.24
BXGC0020637 4-hydroxybenzamide 137.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein