Showing entry for Transcobalamin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008543
Protein NameTranscobalamin-2
Uniport IdP20062
GeneTCN2
Gene Id6948
DomainCobalamin_bind; DUF4430
Pfam PF01122   PF14478  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04977 Vitamin digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009235 cobalamin metabolic process
Biological Process GO:0015889 cobalamin transport
Biological Process GO:0006824 cobalt ion transport
molecular function GO:0031419 cobalamin binding
molecular function GO:0046872 metal ion binding
cellular component GO:0005768 endosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0043202 lysosomal lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-3296469 Defects in cobalamin (B12) metabolism
R-HSA-3296482 Defects in vitamin and cofactor metabolism
R-HSA-3359454 Defective TCN2 causes hereditary megaloblastic anemia
R-HSA-3359485 Defective CD320 causes methylmalonic aciduria
R-HSA-5668914 Diseases of metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001430 BXGD000054 Adenoma Neoplasms
C0001768 BXGD000075 Agammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0001824 BXGD000081 Agranulocytosis Hemic and Lymphatic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002886 BXGD000144 Anemia, Macrocytic Hemic and Lymphatic Diseases
C0002888 BXGD000145 Anemia, Megaloblastic Hemic and Lymphatic Diseases
C0002892 BXGD000149 Anemia, Pernicious Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0016412 BXGD001058 Folic Acid Deficiency Nutritional and Metabolic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023418 BXGD001642 leukemia Neoplasms
C0024291 BXGD001757 Lymphohistiocytosis, Hemophagocytic Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025500 BXGD001874 Mesothelioma Neoplasms
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026633 BXGD001910 Mouth Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041234 BXGD002901 Chagas Disease Infections
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0041782 BXGD002934 Deficiency anemias Hemic and Lymphatic Diseases
C0042847 BXGD003006 Vitamin B 12 Deficiency Nutritional and Metabolic Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0205646 BXGD004098 Adenoma, Basal Cell Neoplasms
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0205648 BXGD004100 Adenoma, Microcystic Neoplasms
C0205649 BXGD004101 Adenoma, Monomorphic Neoplasms
C0205650 BXGD004102 Papillary adenoma Neoplasms
C0205651 BXGD004103 Adenoma, Trabecular Neoplasms
C0220810 BXGD004346 Congenital defects
C0238801 BXGD004957 Bone marrow megaloblastic (finding)
C0267537 BXGD005756 Typhlitis Digestive System Diseases; Infections
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280803 BXGD006766 Primary central nervous system lymphoma Neoplasms; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0342701 BXGD007529 Transcobalamin II deficiency
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400823 BXGD008259 Neutropenic colitis Digestive System Diseases; Hemic and Lymphatic Diseases
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0700216 BXGD009881 Structural Clinical Interview for DSM-III
C0795690 BXGD010728 Congenital omphalocele Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0810364 BXGD010846 Cleft Lip with or without Cleft Palate
C0858867 BXGD011196 Reticulocytopenia
C0917996 BXGD011425 Cerebral Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1852146 BXGD015261 DERMODISTORTIVE URTICARIA Skin and Connective Tissue Diseases; Immune System Diseases
C1853238 BXGD015320 Conotruncal defect
C1855119 BXGD015463 Methylmalonic aciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1858991 BXGD015841 Childhood Ataxia with Central Nervous System Hypomyelinization Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887639 BXGD019907 Autoimmune gastritis Digestive System Diseases
C4021813 BXGD020799 Oral cleft
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551705 BXGD023397 Abnormality of chromosome stability
C4552810 BXGD023525 Irritability, CTCAE
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003751 Cyanide 26.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein