protein

Showing entry for Calpain-3

General Target Information
BXGT Id	BXGT008601
Protein Name	Calpain-3
Uniport Id	P20807
Gene	CAPN3
Gene Id	825
Domain	Calpain_III; Calpain_u2; EF-hand_5; Peptidase_C2
Pfam	PF01067 PF13202 PF00648
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:1990092	calcium-dependent self proteolysis
Biological Process	GO:0071277	cellular response to calcium ion
Biological Process	GO:0071472	cellular response to salt stress
Biological Process	GO:0070315	G1 to G0 transition involved in cell differentiation
Biological Process	GO:0046716	muscle cell cellular homeostasis
Biological Process	GO:0007517	muscle organ development
Biological Process	GO:0061061	muscle structure development
Biological Process	GO:0030239	myofibril assembly
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0033234	negative regulation of protein sumoylation
Biological Process	GO:0045892	negative regulation of transcription, DNA-templated
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity
Biological Process	GO:0045862	positive regulation of proteolysis
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
Biological Process	GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated
Biological Process	GO:0030163	protein catabolic process
Biological Process	GO:0065003	protein-containing complex assembly
Biological Process	GO:0031648	protein destabilization
Biological Process	GO:0072657	protein localization to membrane
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0050790	regulation of catalytic activity
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0045661	regulation of myoblast differentiation
Biological Process	GO:0051592	response to calcium ion
Biological Process	GO:0014850	response to muscle activity
Biological Process	GO:0045214	sarcomere organization
Biological Process	GO:0097264	self proteolysis
molecular function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
molecular function	GO:0005509	calcium ion binding
molecular function	GO:0003824	catalytic activity
molecular function	GO:0008234	cysteine-type peptidase activity
molecular function	GO:0042802	identical protein binding
molecular function	GO:0055103	ligase regulator activity
molecular function	GO:0060090	molecular adaptor activity
molecular function	GO:0008233	peptidase activity
molecular function	GO:0031402	sodium ion binding
molecular function	GO:0008307	structural constituent of muscle
molecular function	GO:0031432	titin binding
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol
cellular component	GO:0005622	intracellular
cellular component	GO:0030016	myofibril
cellular component	GO:0005634	nucleus
cellular component	GO:0005886	plasma membrane
cellular component	GO:0032991	protein-containing complex
cellular component	GO:0030315	T-tubule
cellular component	GO:0030018	Z disc

Reactome

Pathway Id	Pathway Name
R-HSA-1474228	Degradation of the extracellular matrix
R-HSA-1474244	Extracellular matrix organization

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001948	BXGD000091	Alcohol consumption	Behavior and Behavior Mechanisms
C0004604	BXGD000278	Back Pain	Pathological Conditions, Signs and Symptoms
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0009917	BXGD000635	Contracture	Musculoskeletal Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011876	BXGD000758	Cataract due to diabetes mellitus	Eye Diseases
C0013264	BXGD000808	Muscular Dystrophy, Duchenne	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013404	BXGD000833	Dyspnea	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014457	BXGD000915	Eosinophilia	Hemic and Lymphatic Diseases
C0023827	BXGD001707	liposarcoma	Neoplasms
C0023903	BXGD001720	Liver neoplasms	Digestive System Diseases; Neoplasms
C0024003	BXGD001726	Lordosis	Musculoskeletal Diseases
C0025202	BXGD001832	melanoma	Neoplasms
C0026106	BXGD001889	Mild Mental Retardation	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026848	BXGD001941	Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C0026850	BXGD001942	Muscular Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027121	BXGD001973	Myositis	Musculoskeletal Diseases; Nervous System Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027868	BXGD002053	Neuromuscular Diseases	Nervous System Diseases
C0027877	BXGD002055	Neuronal Ceroid-Lipofuscinoses	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030554	BXGD002239	Paresthesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033626	BXGD002412	Protein Deficiency	Nutritional and Metabolic Diseases
C0036439	BXGD002615	Scoliosis, unspecified	Musculoskeletal Diseases
C0037317	BXGD002689	Sleep disturbances	Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037772	BXGD002703	Spastic Paraplegia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039494	BXGD002814	Temporomandibular Joint Disorders	Musculoskeletal Diseases; Stomatognathic Diseases
C0039496	BXGD002815	Temporomandibular Joint Dysfunction Syndrome	Musculoskeletal Diseases; Stomatognathic Diseases
C0085078	BXGD003118	Lysosomal Storage Diseases	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0151786	BXGD003475	Muscle Weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0158113	BXGD003875	Contracture of joint of hand	Musculoskeletal Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0200637	BXGD004042	Monocyte count procedure
C0202236	BXGD004086	Triglycerides measurement
C0205711	BXGD004113	Pelizaeus-Merzbacher Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0206624	BXGD004190	Hepatoblastoma	Neoplasms
C0221629	BXGD004467	Proximal muscle weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0231528	BXGD004496	Myalgia	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0233844	BXGD004620	Clumsiness	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0234233	BXGD004636	Sore to touch	Pathological Conditions, Signs and Symptoms; Mental Disorders
C0234958	BXGD004702	Muscle degeneration	Musculoskeletal Diseases
C0238190	BXGD004890	Inclusion Body Myositis (disorder)	Musculoskeletal Diseases; Nervous System Diseases
C0238288	BXGD004905	Muscular Dystrophy, Facioscapulohumeral	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0239067	BXGD004961	Difficulty walking up stairs	Pathological Conditions, Signs and Symptoms
C0240914	BXGD005063	Romberg's sign positive
C0240953	BXGD005067	Winged scapula
C0241005	BXGD005072	Creatine phosphokinase serum increased
C0241237	BXGD005088	Difficulty standing	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0268281	BXGD005882	Infantile neuronal ceroid lipofuscinosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0270850	BXGD006117	Idiopathic generalized epilepsy	Nervous System Diseases
C0279626	BXGD006657	Squamous cell carcinoma of esophagus	Digestive System Diseases; Neoplasms
C0311394	BXGD006884	Difficulty walking	Pathological Conditions, Signs and Symptoms
C0333068	BXGD006920	Flexion contracture	Musculoskeletal Diseases
C0337428	BXGD007155	Fibrinogen assay
C0345904	BXGD007745	Malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0392885	BXGD008071	High density lipoprotein measurement
C0409338	BXGD008381	Flexion contracture - elbow
C0409345	BXGD008382	Flexion contracture - wrist
C0410173	BXGD008409	Severe autosomal recessive muscular dystrophy of childhood - North African type (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Nervous System Diseases; Cardiovascular Diseases
C0410189	BXGD008413	Muscular Dystrophy, Emery-Dreifuss	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0410266	BXGD008424	Contracture of hamstring(s)	Musculoskeletal Diseases
C0427063	BXGD008602	Shoulder girdle weakness
C0427144	BXGD008607	Toe-walking gait
C0541794	BXGD009262	Skeletal muscle atrophy
C0557874	BXGD009444	Global developmental delay
C0558845	BXGD009459	Reflex, Ankle, Absent	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575081	BXGD009512	Gait abnormality	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0587246	BXGD009616	Muscle weakness of limb	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0686353	BXGD009833	Muscular Dystrophies, Limb-Girdle	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0699743	BXGD009862	Congenital muscular dystrophy (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0745091	BXGD010113	Hypereosinophilia	Hemic and Lymphatic Diseases
C0746674	BXGD010147	Generalized muscle weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0750880	BXGD010239	Monocyte count result
C0751383	BXGD010422	Juvenile Neuronal Ceroid Lipofuscinosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751713	BXGD010564	Inclusion Body Myopathy, Sporadic	Musculoskeletal Diseases; Nervous System Diseases
C0855329	BXGD011084	Electrocardiogram change
C0917713	BXGD011404	Becker Muscular Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1145670	BXGD011764	Respiratory Failure	Respiratory Tract Diseases
C1299884	BXGD012265	Eosinophilic myositis (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1328504	BXGD012469	Hormone refractory prostate cancer	Neoplasms; Male Urogenital Diseases
C1389113	BXGD012965	Generalized amyotrophy
C1393871	BXGD012979	Congenital finger flexion contractures
C1456418	BXGD013117	Absence of muscle
C1611743	BXGD013456	Familial (FPAH)
C1832661	BXGD013866	ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1834582	BXGD013982	MYELOPROLIFERATIVE SYNDROME, TRANSIENT	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Hemic and Lymphatic Diseases
C1834671	BXGD013985	FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1B	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1834674	BXGD013987	BETHLEM MYOPATHY 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1836057	BXGD014076	Muscle fiber splitting
C1836296	BXGD014105	Muscle Weakness Lower Limb	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836767	BXGD014159	Proximal lower limb amyotrophy
C1838244	BXGD014304	TIBIAL MUSCULAR DYSTROPHY, TARDIVE	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1843057	BXGD014552	Calf muscle hypertrophy
C1850794	BXGD015178	Proximal amyotrophy
C1850808	BXGD015179	Miyoshi myopathy
C1850889	BXGD015185	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2B	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1852502	BXGD015286	CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT	Musculoskeletal Diseases; Stomatognathic Diseases
C1858025	BXGD015760	Spinal rigidity
C1858127	BXGD015775	Limb-girdle muscle weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1859523	BXGD015908	Contractures of the joints of the lower limbs
C1861922	BXGD016094	CAMPOMELIC DYSPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1866010	BXGD016360	Proximal muscle weakness in lower limbs
C1866012	BXGD016361	Proximal muscle weakness in upper limbs
C1869123	BXGD016553	Limb-girdle muscular dystrophy type 2A	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2676033	BXGD017322	Hepatoblastoma Caused By Somatic Mutation	Digestive System Diseases; Neoplasms
C2678065	BXGD017398	Myofibrillar Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C2827469	BXGD017798	Coronary Microvascular Disease
C2931673	BXGD018046	Ceroid lipofuscinosis, neuronal 1, infantile	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2931687	BXGD018048	Dysferlinopathy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2936331	BXGD018106	Sarcoglycanopathies	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Nervous System Diseases; Cardiovascular Diseases
C2936332	BXGD018107	Alpha-Sarcoglycanopathies	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Nervous System Diseases; Cardiovascular Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C3805969	BXGD019495	Scapular muscle atrophy
C3887485	BXGD019877	MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1
C3888204	BXGD019959	ACTN3 DEFICIENCY
C4020732	BXGD020474	Mitochondrial abnormalities
C4021527	BXGD020654	Abdominal wall muscle weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C4021528	BXGD020655	Pelvic girdle amyotrophy
C4021726	BXGD020735	EMG: myopathic abnormalities	Musculoskeletal Diseases; Nervous System Diseases
C4021727	BXGD020736	EMG: neuropathic changes
C4022625	BXGD020939	Absent muscle fiber calpain-3
C4023066	BXGD021092	Pectoralis amyotrophy
C4082951	BXGD022096	Progressive spinal muscular atrophy	Nervous System Diseases
C4275181	BXGD022370	Autosomal recessive limb girdle muscular dystrophy type 2A
C4551915	BXGD023441	Gait Disturbance, CTCAE
C4551973	BXGD023459	Miyoshi Muscular Dystrophy 1	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4552811	BXGD023526	Generalized Muscle Weakness, CTCAE
C4724975	BXGD023820	HyperCKmia
C4748295	BXGD023998	MUSCULAR DYSTROPHY, LIMB-GIRDLE, AUTOSOMAL DOMINANT 4
C4755301	BXGD024093	Idiopathic eosinophilic myositis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002586	Calcium		40.08
BXGC0003705	Chloride		35.45
BXGC0005511	D-Glucitol		182.17

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}