Showing entry for Activin receptor type-2A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009153
Protein NameActivin receptor type-2A
Uniport IdP27037
GeneACVR2A
Gene Id92
DomainActivin_recp; Pkinase
Pfam PF01064   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032924 activin receptor signaling pathway
Biological Process GO:0009952 anterior/posterior pattern specification
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0071773 cellular response to BMP stimulus
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0007368 determination of left/right symmetry
Biological Process GO:0048706 embryonic skeletal system development
Biological Process GO:0001702 gastrulation with mouth forming second
Biological Process GO:0007498 mesoderm development
Biological Process GO:0043084 penile erection
Biological Process GO:0032927 positive regulation of activin receptor signaling pathway
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0050999 regulation of nitric-oxide synthase activity
Biological Process GO:0060011 Sertoli cell proliferation
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0042713 sperm ejaculation
Biological Process GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
molecular function GO:0048185 activin binding
molecular function GO:0005524 ATP binding
molecular function GO:0098821 BMP receptor activity
molecular function GO:0015026 coreceptor activity
molecular function GO:0019838 growth factor binding
molecular function GO:0034711 inhibin binding
molecular function GO:0046872 metal ion binding
molecular function GO:0030165 PDZ domain binding
molecular function GO:0043621 protein self-association
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004675 transmembrane receptor protein serine/threonine kinase activity
cellular component GO:0048179 activin receptor complex
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0034673 inhibin-betaglycan-ActRII complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1181150 Signaling by NODAL
R-HSA-1266738 Developmental Biology
R-HSA-1433617 Regulation of signaling by NODAL
R-HSA-1502540 Signaling by Activin
R-HSA-1502540 Signaling by Activin
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-201451 Signaling by BMP
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9006936 Signaling by TGFB family members
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0008476 BXGD000543 Chondromatosis, Synovial Musculoskeletal Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0013537 BXGD000853 Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0014084 BXGD000891 Enchondromatosis Musculoskeletal Diseases
C0015306 BXGD000975 Hereditary Multiple Exostoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases
C0017185 BXGD001104 Gastrointestinal Neoplasms Digestive System Diseases; Neoplasms
C0017654 BXGD001136 Glomerular Filtration Rate
C0018021 BXGD001162 Goiter Endocrine System Diseases
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0024814 BXGD001809 Marinesco-Sjogren syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029427 BXGD002144 Synovial osteochondromatosis Musculoskeletal Diseases
C0031900 BXGD002313 Pierre Robin Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0154084 BXGD003699 Stage 0 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0206641 BXGD004206 Osteochondromatosis Neoplasms; Musculoskeletal Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0264009 BXGD005361 Osteodystrophy Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278803 BXGD006593 Adenocarcinoma of small intestine Digestive System Diseases; Neoplasms
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0852519 BXGD010946 Benign chondrogenic neoplasm Neoplasms
C0871470 BXGD011316 Systolic Pressure
C0920269 BXGD011462 Microsatellite Instability Pathological Conditions, Signs and Symptoms
C0936248 BXGD011480 Chondroma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332922 BXGD012556 Cervical Squamous Intraepithelial Neoplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1391732 BXGD012971 Cancer cachexia
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1567741 BXGD013414 Alport Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C1721098 BXGD013705 Replication Error Phenotype Pathological Conditions, Signs and Symptoms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C4520821 BXGD023039 Stage 0 Breast Cancer AJCC v6 and v7 Neoplasms; Skin and Connective Tissue Diseases
C4543877 BXGD023280 Osteopenia due to disuse Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C4544822 BXGD023286 Microsatellite instability-high colorectal cancer Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030612 tetraethylene glycol 194.12
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein