Showing entry for 3-oxo-5-alpha-steroid 4-dehydrogenase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009515
Protein Name3-oxo-5-alpha-steroid 4-dehydrogenase 2
Uniport IdP31213
GeneSRD5A2
Gene Id6716
DomainSteroid_dh
Pfam PF02544  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006702 androgen biosynthetic process
Biological Process GO:0008209 androgen metabolic process
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0030154 cell differentiation
Biological Process GO:0030539 male genitalia development
Biological Process GO:0008584 male gonad development
Biological Process GO:0006694 steroid biosynthetic process
Biological Process GO:0061370 testosterone biosynthetic process
molecular function GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity
molecular function GO:0047751 cholestenone 5-alpha-reductase activity
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0009917 sterol 5-alpha reductase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
molecular function GO:0030283 testosterone dehydrogenase NAD(P) activity
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-193048 Androgen biosynthesis
R-HSA-196071 Metabolism of steroid hormones
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0005001 BXGD000302 Benign prostatic hypertrophy Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008043 BXGD000513 Chiari-Frommel Syndrome Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0018051 BXGD001167 Gonadal Dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020514 BXGD001414 Hyperprolactinemia Nervous System Diseases; Endocrine System Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028960 BXGD002101 Oligospermia Male Urogenital Diseases
C0029489 BXGD002163 Other alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033575 BXGD002407 Prostatic Diseases Male Urogenital Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033804 BXGD002426 Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036875 BXGD002640 Disorders of Sex Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0041408 BXGD002923 Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0086873 BXGD003313 Pseudopelade Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0162311 BXGD003935 Androgenetic Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0178879 BXGD004038 Urinary tract obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0201657 BXGD004051 C-reactive protein measurement
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0238395 BXGD004922 Male Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0263477 BXGD005311 Female pattern alopecia (disorder) Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0265987 BXGD005598 Nevus comedonicus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0268297 BXGD005889 Pseudovaginal Perineoscrotal Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0341787 BXGD007422 Bifid scrotum
C0342513 BXGD007494 Idiopathic hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0345326 BXGD007727 Congenital phimosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0403766 BXGD008309 Acquired phimosis Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0431659 BXGD008699 Hypoplasia of scrotum
C0432470 BXGD008792 46, XY female Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0452148 BXGD008833 Hypospadias, perineal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0520477 BXGD009087 Prostatic Adenoma Male Urogenital Diseases
C0520927 BXGD009124 Decreased fertility
C0521991 BXGD009187 Symptoms of stress
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0555232 BXGD009435 pseudohermaphrodite (non-specific)
C0565599 BXGD009488 Maternal hypertension Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0574785 BXGD009506 Lower Urinary Tract Symptoms Pathological Conditions, Signs and Symptoms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0852654 BXGD010947 21-hydroxylase deficiency
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C0949628 BXGD011581 Uniparental Disomy Pathological Conditions, Signs and Symptoms
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1291316 BXGD012210 Deficiency of reductase
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1691215 BXGD013491 Penile hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1739135 BXGD013733 Progression of prostate cancer
C1739363 BXGD013734 Prostatic Hypertrophy Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2676272 BXGD017331 Alopecia, Androgenetic, 3 Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C2678038 BXGD017394 Alopecia, Androgenetic, 2 Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C2751824 BXGD017742 46, XY Disorders of Sex Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2930619 BXGD017890 Sex Differentiation Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2931456 BXGD018024 Prostate cancer, familial Neoplasms; Male Urogenital Diseases
C2937421 BXGD018162 Prostatic Hyperplasia Male Urogenital Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3273019 BXGD018642 Early Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C3669122 BXGD019324 5-Alpha Reductase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4020961 BXGD020511 Displacement of the external urethral meatus
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4021776 BXGD020772 Abnormality of the voice
C4021823 BXGD020808 Ambiguous genitalia, male Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4021972 BXGD020849 Urogenital sinus anomaly
C4025823 BXGD021811 Abnormality of the endocrine system
C4049090 BXGD021913 Alopecia, Androgenetic, 1
C4083212 BXGD022105 Alopecia, Male Pattern Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C4551492 BXGD023317 Micropenis
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722328 BXGD023800 Hereditary Prostate Carcinoma Neoplasms; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003611 Latex 416.57
BXGC0005894 Azelaic acid 188.22
BXGC0017757 Androstenedione 286.19
BXGC0028471 Monoolein 356.29
BXGC0047405 Gamolenic Acid 278.22
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein