Showing entry for Casein kinase I isoform alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010655
Protein NameCasein kinase I isoform alpha
Uniport IdP48729
GeneCSNK1A1
Gene Id1452
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.2 Cancers: Specific types hsa05224 Breast cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1904885 beta-catenin destruction complex assembly
Biological Process GO:1904886 beta-catenin destruction complex disassembly
Biological Process GO:0007049 cell cycle
Biological Process GO:0051301 cell division
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0007030 Golgi organization
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:1904424 regulation of GTP binding
Biological Process GO:0007165 signal transduction
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0016301 kinase activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0030877 beta-catenin destruction complex
cellular component GO:0005813 centrosome
cellular component GO:0036064 ciliary basal body
cellular component GO:0005929 cilium
cellular component GO:0000777 condensed chromosome kinetochore
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:1990904 ribonucleoprotein complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-195721 Signaling by WNT
R-HSA-195721 Signaling by WNT
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4791275 Signaling by WNT in cancer
R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling
R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
R-HSA-4839744 truncated APC mutants destabilize the destruction complex
R-HSA-4839748 AMER1 mutants destabilize the destruction complex
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5635838 Activation of SMO
R-HSA-5635838 Activation of SMO
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001623 BXGD000066 Adrenal gland hypofunction Endocrine System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026470 BXGD001903 Monoclonal Gammopathy of Undetermined Significance Immune System Diseases; Hemic and Lymphatic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0032131 BXGD002330 Plasmacytoma Neoplasms; Immune System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0405580 BXGD008325 Adrenal cortical hypofunction Endocrine System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0740302 BXGD009975 5q-syndrome Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0836924 BXGD010864 Thrombocytosis Hemic and Lymphatic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1292779 BXGD012238 Myelodysplastic Syndrome with Isolated del(5q) Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1802398 BXGD013758 Chromosome 5, trisomy 5q Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0001545 Harmine 212.25
BXGC0002071 Apigenin 270.24
BXGC0007029 Emodin 270.24
BXGC0013109 4-[2-(3,5-Dihydroxyphenyl)Ethenyl]Benzene-1,2-Diol 244.07
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047295 n.a 236.06
BXGC0047692 Gefitinib 446.15
BXGC0050854 Ricinine 164.06
BXGC0053494 Quinizarin 240.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein