Showing entry for PHD finger protein 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018356
Protein NamePHD finger protein 6
Uniport IdQ8IWS0
GenePHF6
Gene Id84295
Domainzf-HC5HC2H
Pfam -  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001835 blastocyst hatching
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:0019899 enzyme binding
molecular function GO:0042393 histone binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0046872 metal ion binding
molecular function GO:0051219 phosphoprotein binding
molecular function GO:0043021 ribonucleoprotein complex binding
molecular function GO:0003723 RNA binding
molecular function GO:0097110 scaffold protein binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0015631 tubulin binding
cellular component GO:0000777 condensed chromosome kinetochore
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0005744 BXGD000330 Blepharophimosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018418 BXGD001192 Gynecomastia Skin and Connective Tissue Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023485 BXGD001667 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024814 BXGD001809 Marinesco-Sjogren syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026985 BXGD001956 Myelodysplasia
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034012 BXGD002449 Delayed Puberty Endocrine System Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220615 BXGD004298 Adult Acute Myeloblastic Leukemia Neoplasms
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0241355 BXGD005092 Small testicle
C0265338 BXGD005522 Coffin-Siris syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases; Behavior and Behavior Mechanisms
C0265339 BXGD005523 Borjeson-Forssman-Lehmann syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0265610 BXGD005555 Clinodactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279583 BXGD006640 Childhood T Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279646 BXGD006670 Childhood Acute Monocytic Leukemia Neoplasms
C0280141 BXGD006716 Acute Undifferentiated Leukemia
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280634 BXGD006753 Adult Acute Monocytic Leukemia Neoplasms
C0349588 BXGD007933 Short stature
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0426886 BXGD008594 Tapering fingers (finding)
C0431659 BXGD008699 Hypoplasia of scrotum
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0522631 BXGD009205 Acute myeloid leukemia, minimal differentiation Neoplasms
C0541794 BXGD009262 Skeletal muscle atrophy
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306341 BXGD012360 Mental handicap
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318544 BXGD012401 M5b Acute differentiated monocytic leukemia Neoplasms; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1691215 BXGD013491 Penile hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1836195 BXGD014094 Short toe
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1837770 BXGD014270 Sparse hair
C1842060 BXGD014491 Prominent supraorbital ridges
C1844573 BXGD014646 Large earlobe
C1844923 BXGD014694 Hypoplasia of the prostate
C1844925 BXGD014695 Cervical spinal canal stenosis
C1844926 BXGD014696 Scheuermann-like vertebral changes Musculoskeletal Diseases
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1845977 BXGD014769 X- linked recessive
C1853487 BXGD015340 Thick eyebrow
C1856912 BXGD015656 Shortening of all middle phalanges of the fingers
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858452 BXGD015796 Thickened calvaria
C1866241 BXGD016389 Broad foot Musculoskeletal Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1969238 BXGD016769 Widely spaced toes
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2674608 BXGD017250 Feeding difficulties in infancy
C2675021 BXGD017264 Narrow palpebral fissure
C2919142 BXGD017867 Short Stature, CTCAE
C2939461 BXGD018180 Myeloid neoplasm Neoplasms; Hemic and Lymphatic Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3553764 BXGD019187 Joint hyperflexibility
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4012968 BXGD020124 Mild global developmental delay
C4021004 BXGD020519 Short middle phalanx of the 4th toe
C4021608 BXGD020695 Shortening of all distal phalanges of the fingers
C4021735 BXGD020743 Abnormality of the hip bone
C4021774 BXGD020770 Camptodactyly of toe
C4021813 BXGD020799 Oral cleft
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551485 BXGD023312 Clinodactyly
C4551560 BXGD023349 Truncal obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4551570 BXGD023357 2-3 toe syndactyly
C4551838 BXGD023417 Talipes transversoplanus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein