Showing entry for Curcumin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0005982
Compound NameCurcumin
Structure
FormulaC21H20O6
InchiKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
SMILESCOC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC(OC)=C(O)C=C2)=CC=C1O
InchiInChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
IUPAC(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Molecular Weight368.38
Pubchem Id969516
Chembl IdCHEMBL140
Targets of Information Source
DrugBank DB11672
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG approved; experimental; investigational -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR approved; experimental; investigational -
O15440 BXGT004170 Multidrug resistance-associated protein 5 reviewed Transporter ABCC5 approved; experimental; investigational inhibitor
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 reviewed - CBR1 approved; experimental; investigational -
P09211 BXGT006869 Glutathione S-transferase P reviewed - GSTP1 approved; experimental; investigational -
PDB CC9
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed DYRK2 Kinase - - - -
Binding DB 50140172
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006869 Glutathione S-transferase P reviewed GSTP1 - 69000 - -
reviewed BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR - 8650 - -
reviewed BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP - 11300 - -
reviewed BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 - 343000 - -
reviewed BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B - 17950 - -
reviewed BXGT013038 Histone acetyltransferase p300 reviewed EP300 - 6500 - -
reviewed BXGT013038 Histone acetyltransferase p300 reviewed EP300 - 25000 - -
reviewed BXGT019374 CREB-binding protein reviewed CREBBP - 25000 - -
reviewed BXGT009172 Amine oxidase [flavin-containing] B reviewed MAOB 21500 - - -
reviewed BXGT008644 Amine oxidase [flavin-containing] A reviewed MAOA 710 - - -
reviewed BXGT022346 Lymphocyte antigen 96 reviewed Receptor LY96 - - 379000 -
reviewed BXGT004925 Prostaglandin G/H synthase 2 reviewed PTGS2 - 2000 - -
reviewed BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP - 3100 - -
reviewed BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP - 1500 - -
reviewed BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP - 21810 - -
reviewed BXGT006364 Neuronal proto-oncogene tyrosine-protein kinase Src reviewed Src - 2200 - -
reviewed BXGT007596 Microtubule-associated protein tau reviewed MAPT - 3000 - -
reviewed BXGT021269 CDGSH iron-sulfur domain-containing protein 1 reviewed CISD1 - 2360 - -
reviewed BXGT021269 CDGSH iron-sulfur domain-containing protein 1 reviewed CISD1 101 - - -
CHEMBL CHEMBL140
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 12589 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 2511 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 1122 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 21136 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 12589 nM
Q9NZ45 BXGT021269 CDGSH iron-sulfur domain-containing protein 1 reviewed - CISD1 Ki '=' 101 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 34 %
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 25118 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 68 %
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 IC50 '=' 343000 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 630 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 31622 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 2511 nM
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM Potency '=' 28183 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 35481 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Potency - 3162 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 1500 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 41 %
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 29092 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 7943 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16788 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 39810 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 39810 nM
P05480 BXGT006364 Neuronal proto-oncogene tyrosine-protein kinase Src reviewed - Src IC50 '=' 2200 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 46 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 18250 nM
O60240 BXGT004860 Perilipin-1 reviewed - PLIN1 IC50 '=' 9167 nM
Q8WTS1 BXGT018985 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 reviewed - ABHD5 IC50 '=' 9167 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition - - -
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 10000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 50118 nM
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B IC50 '=' 17950 nM
P55210 BXGT011110 Caspase-7 reviewed Enzyme CASP7 Potency '=' 12589 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 35481 nM
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 39810 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 50118 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 22387 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 20314 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 16360 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 26679 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 31622 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 15848 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 28183 nM
P24822 BXGT008996 Intestinal-type alkaline phosphatase reviewed - Iap IC50 '=' 18700 nM
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 33491 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '>' 100000 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 63095 nM
Q9NR96 BXGT021181 Toll-like receptor 9 reviewed - TLR9 IC50 '=' 8362 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 3548 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 50118 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 21331 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 89125 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 7943 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 18356 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 79 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 44668 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 35481 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 79432 nM
Q99816 BXGT019966 Tumor susceptibility gene 101 protein reviewed Enzyme TSG101 Potency - 19952 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 89125 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 35481 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 14125 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 17782 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 53 %
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 35481 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 6309 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 31622 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 Inhibition - - -
Q932Y6 BXGT019466 Beta-lactamase unreviewed - bla(tem-2) IC50 '=' 7751 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 11220 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 11220 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '=' 24 %
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 15848 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 15848 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 22387 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 1778 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 14125 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 56 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 35 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT IC50 '=' 3000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 56 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 18730 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 35481 nM
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 IC50 '=' 6500 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 13335 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 25118 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 11300 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 3981 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 3981 nM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 79432 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 10000 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 10000 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Inhibition - - -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 39810 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 44668 nM
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 IC50 '=' 25000 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 32196 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 15848 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 65 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 0 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition - - -
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 35481 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Inhibition - - -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Inhibition - - -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Inhibition - - -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Inhibition - - -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Inhibition - - -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Inhibition - - -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Inhibition - - -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Inhibition - - -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Inhibition - - -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Inhibition - - -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Inhibition - - -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Inhibition - - -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Inhibition - - -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Inhibition - - -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Inhibition - - -
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency '=' 5011 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 7079 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 56234 nM
P42858 BXGT010341 Huntingtin reviewed - HTT Potency '=' 3548 nM
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 316 nM
P10145 BXGT007542 Interleukin-8 reviewed Signaling CXCL8 Potency - 84126 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 31622 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9441 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 55 %
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 44668 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 70794 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 14125 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 14125 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 44668 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 31622 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 31622 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 17740 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 22387 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 9000 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 44668 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 39810 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 35481 nM
Q92793 BXGT019374 CREB-binding protein reviewed - CREBBP IC50 '=' 25000 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 44668 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 31622 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '>' 300000 nM
O14684 BXGT004082 Prostaglandin E synthase reviewed - PTGES IC50 '=' 200 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 56 %
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 11220 nM
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 52 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 132130 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 53 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 3100 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 50118 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 31622 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 25118 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Activity '=' 57 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 28183 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 28183 nM
O14684 BXGT004082 Prostaglandin E synthase reviewed - PTGES IC50 '=' 220 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 15848 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 19952 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition - - -
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency - 50118 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 39506 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 7307 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 19952 nM
P87108 BXGT012099 Mitochondrial import inner membrane translocase subunit TIM10 reviewed - TIM10 IC50 '=' 19700 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 21131 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 39810 nM
Q8IUX4 BXGT018337 DNA dC->dU-editing enzyme APOBEC-3F reviewed Enzyme APOBEC3F Potency - 22387 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 50118 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 12589 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 12589 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 7079 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 7079 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 3981 nM
P65502 BXGT011541 Probable nicotinate-nucleotide adenylyltransferase reviewed - nadD IC50 - 23100 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 8912 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 43 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 11582 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '>' 100000 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 44668 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 35481 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 35481 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 35481 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 39810 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 19952 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 21136 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 52 %
O62698 BXGT004925 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 2000 nM
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 2000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 9900 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Activity - - -
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Activity - - -
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Activity - - -
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Activity - - -
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Activity - - -
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Activity - - -
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Activity - - -
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Activity - - -
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Activity - - -
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Activity - - -
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Activity - - -
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Activity - - -
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Activity - - -
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Activity - - -
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Activity - - -
Q9NZ45 BXGT021269 CDGSH iron-sulfur domain-containing protein 1 reviewed - CISD1 IC50 '=' 2360 nM
P65502 BXGT011541 Probable nicotinate-nucleotide adenylyltransferase reviewed - nadD IC50 - 62700 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 - - -
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '>' 100000 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '>' 100000 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '>' 100000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 25918 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 42 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29855 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 67 %
P11308 BXGT007684 Transcriptional regulator ERG reviewed Transcription factor ERG Potency - 15848 nM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 12589 nM
P35869 BXGT009877 Aryl hydrocarbon receptor reviewed Transcription factor AHR Potency - 56234 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 14125 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition - - -
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P10696 BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG IC50 '>' 100000 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 35481 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 28183 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 70794 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Activity - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 1000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 51 %
P0A031 BXGT006961 Cell division protein FtsZ reviewed - ftsZ INH '=' 1024 ug ml-1
Q9Y6Y9 BXGT022346 Lymphocyte antigen 96 reviewed Receptor LY96 Kd '=' 379000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Activity - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 3300 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 52 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 54 %
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 36 %
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 35481 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 21810 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 '=' 8650 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 55 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 25929 nM
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 IC50 '=' 187000 nM
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 IC50 '=' 187000 nM
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 IC50 '=' 187000 nM
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 IC50 '=' 187000 nM
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 IC50 '=' 187000 nM
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 IC50 '=' 187000 nM
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 IC50 '=' 187000 nM
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 IC50 '=' 187000 nM
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 IC50 '=' 187000 nM
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 IC50 '=' 187000 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 IC50 '=' 187000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 36 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 EC50 '=' 21000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 3264 nM
Q8WTS1 BXGT018985 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 reviewed - ABHD5 IC50 '=' 10232 nM
Q00G26 BXGT012560 Perilipin-5 reviewed - PLIN5 IC50 '=' 10232 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE Inhibition '=' 3 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 40 %
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki '=' 710 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 5400 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT IC50 '=' 13000 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT IC50 '=' 3500 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 39810 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP DC50 '=' 0 uM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Ki '=' 21500 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 800 nM
Q13153 BXGT013319 Serine/threonine-protein kinase PAK 1 reviewed Kinase PAK1 IC50 '=' 16000 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '>' 5000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 57 %
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 39 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Activity - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 39 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 51 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Activity '>' 75 %
P18266 BXGT008394 Glycogen synthase kinase-3 beta reviewed - Gsk3b IC50 '=' 66 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 51 %
O14684 BXGT004082 Prostaglandin E synthase reviewed - PTGES IC50 '=' 300 nM
P37059 BXGT009957 Estradiol 17-beta-dehydrogenase 2 reviewed Enzyme HSD17B2 IC50 '=' 1730 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 56 %
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Inhibition - - -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 14990 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 43 %
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 50118 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 22510 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 10000 nM
P13726 BXGT007950 Tissue factor reviewed Receptor F3 IC50 '=' 13 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Activity '=' 57 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 46 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP DC50 '=' 0 uM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '>' 5000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 54 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 FC '=' 22 -
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 47 %
P15144 BXGT008087 Aminopeptidase N reviewed Enzyme ANPEP IC50 '=' 15500 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 65 %
Q92793 BXGT019374 CREB-binding protein reviewed - CREBBP IC50 '=' 25000 nM
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 IC50 '=' 25000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '=' 3400 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00068 Turmeric Curcuma longa Herbs and Spices
BXGF00206 Ginger Zingiber officinale Herbs and Spices
BXGF00635 Curry powder Herbs and Spices
BXGF00818 Herbs and Spices Herbs and Spices
BXGF01594 Tacca chantrieri Tacca chantrieri Medicinal Plant
BXGF02616 Curcuma phaeocaulis Curcuma phaeocaulis Others
BXGF03536 Curcuma kwangsiensis Curcuma kwangsiensis Medicinal Plant
BXGF03970 Goniothalamus borneensis Goniothalamus borneensis Others
BXGF03980 Curcuma aromatica Curcuma aromatica Medicinal Plant
BXGF04173 Curcuma wenyujin Curcuma wenyujin Others
BXGF05024 Jacobaea maritima Jacobaea maritima Others
BXGF05816 Fraxinus quadrangulata Fraxinus quadrangulata Medicinal Plant
BXGF05934 Curcuma zedoaria Curcuma zedoaria Medicinal Plant
BXGF06181 Adiantum capillus-veneris Adiantum capillus-veneris Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease