Showing entry for ADP-ribosylation factor-like protein 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020435
Protein NameADP-ribosylation factor-like protein 6
Uniport IdQ9H0F7
GeneARL6
Gene Id84100
DomainArf
Pfam PF00025  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007420 brain development
Biological Process GO:0060271 cilium assembly
Biological Process GO:0007368 determination of left/right symmetry
Biological Process GO:0045444 fat cell differentiation
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0032402 melanosome transport
Biological Process GO:0061512 protein localization to cilium
Biological Process GO:0097499 protein localization to non-motile cilium
Biological Process GO:0051258 protein polymerization
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:1903445 protein transport from ciliary membrane to plasma membrane
Biological Process GO:0008589 regulation of smoothened signaling pathway
Biological Process GO:0010842 retina layer formation
Biological Process GO:0016192 vesicle-mediated transport
Biological Process GO:0007601 visual perception
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0005543 phospholipid binding
cellular component GO:0005879 axonemal microtubule
cellular component GO:0005930 axoneme
cellular component GO:0005929 cilium
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0030117 membrane coat
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-5617833 Cilium Assembly
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220697 BXGD004324 POLYDACTYLY, POSTAXIAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235095 BXGD004723 Visual field constriction Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0266295 BXGD005645 Congenital hypoplasia of kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349588 BXGD007933 Short stature
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0398791 BXGD008233 Nijmegen Breakage Syndrome Nutritional and Metabolic Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0431904 BXGD008713 Ulnar polydactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0521525 BXGD009139 Short neck
C0541794 BXGD009262 Skeletal muscle atrophy
C0685840 BXGD009821 Congenital hypoplasia of ovary Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0730290 BXGD009946 Cone Dystrophy Eye Diseases
C0752166 BXGD010684 Bardet-Biedl Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1408258 BXGD013037 Kidney damage
C1840077 BXGD014434 Anteverted nostril
C1844562 BXGD014645 Medial flaring of the eyebrow
C1845977 BXGD014769 X- linked recessive
C1849211 BXGD015023 Generalized hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1849367 BXGD015046 Nasal bridge wide
C1854113 BXGD015382 Prominent nasal bridge
C1855333 BXGD015489 External genital hypoplasia
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1859564 BXGD015910 Bardet-Biedl syndrome 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1861403 BXGD016045 Variable expressivity
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2675305 BXGD017283 BARDET-BIEDL SYNDROME 1, MODIFIER OF
C2919142 BXGD017867 Short Stature, CTCAE
C2936862 BXGD018148 Bardet-Biedl syndrome 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C3150808 BXGD018340 RETINITIS PIGMENTOSA 55
C3714581 BXGD019415 Multicystic Dysplastic Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4551492 BXGD023317 Micropenis
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4703439 BXGD023647 Abnormality of fundus pigmentation
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0048845 Guanosine Triphosphate 522.99
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein