Showing entry for eIF-2-alpha kinase GCN2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021302
Protein NameeIF-2-alpha kinase GCN2
Uniport IdQ9P2K8
GeneEIF2AK4
Gene Id440275
DomainHGTP_anticodon2; Pkinase; RWD; tRNA-synt_His
Pfam PF12745   PF00069   PF05773   PF13393  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0034198 cellular response to amino acid starvation
Biological Process GO:0070417 cellular response to cold
Biological Process GO:1990253 cellular response to leucine starvation
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0051607 defense response to virus
Biological Process GO:0000077 DNA damage checkpoint
Biological Process GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0007612 learning
Biological Process GO:0007616 long-term memory
Biological Process GO:0044828 negative regulation by host of viral genome replication
Biological Process GO:0032792 negative regulation of CREB transcription factor activity
Biological Process GO:0045665 negative regulation of neuron differentiation
Biological Process GO:0045947 negative regulation of translational initiation
Biological Process GO:0032057 negative regulation of translational initiation in response to stress
Biological Process GO:1990138 neuron projection extension
Biological Process GO:0002821 positive regulation of adaptive immune response
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:1900273 positive regulation of long-term synaptic potentiation
Biological Process GO:0071264 positive regulation of translational initiation in response to starvation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0060733 regulation of eIF2 alpha phosphorylation by amino acid starvation
Biological Process GO:0060259 regulation of feeding behavior
Biological Process GO:0006446 regulation of translational initiation
Biological Process GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
Biological Process GO:0002286 T cell activation involved in immune response
Biological Process GO:0019081 viral translation
molecular function GO:0005524 ATP binding
molecular function GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0000049 tRNA binding
cellular component GO:0022626 cytosolic ribosome
cellular component GO:0005844 polysome
Reactome
Pathway Id Pathway Name
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002514 BXGD000118 Amino Acid Metabolism, Inborn Errors Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0005893 BXGD000346 Body mass index procedure
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018500 BXGD001196 Hair Diseases Skin and Connective Tissue Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0034091 BXGD002463 Pulmonary Veno-Occlusive Disease (disorder) Respiratory Tract Diseases; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037221 BXGD002673 Situs Inversus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0042769 BXGD002999 Virus Diseases Infections
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0201983 BXGD004064 Dehydroepiandrosterone sulfate measurement (procedure)
C0206161 BXGD004167 Reticulocyte count (procedure)
C0220613 BXGD004297 Adult Soft Tissue Sarcoma
C0220645 BXGD004307 Childhood Soft Tissue Sarcoma
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0340543 BXGD007344 Familial primary pulmonary hypertension Respiratory Tract Diseases
C0340548 BXGD007346 Pulmonary capillary hemangiomatosis Neoplasms; Cardiovascular Diseases
C0340848 BXGD007370 PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE Neoplasms; Respiratory Tract Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0428883 BXGD008639 Diastolic blood pressure
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0578022 BXGD009541 Finding of body mass index
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0750905 BXGD010243 Amino Acid Metabolism, Inherited Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0871470 BXGD011316 Systolic Pressure
C1150929 BXGD011768 2-oxo-hept-3-ene-1,7-dioate hydratase activity
C1261473 BXGD011855 Sarcoma Neoplasms
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1701939 BXGD013525 Familial pulmonary arterial hypertension
C1827293 BXGD013768 Carcinoma of urinary bladder, invasive Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2363741 BXGD017100 HIV-1 infection
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2960129 BXGD018198 Vanishing white matter disease Nervous System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3698354 BXGD019369 Pulmonary veno-occlusive disease and/or pulmonary capillary hemangiomatosis
C3887551 BXGD019898 Memory dysfunction Mental Disorders
C3887658 BXGD019913 PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT Respiratory Tract Diseases; Cardiovascular Diseases
C3898127 BXGD020061 Non-Metastatic Childhood Soft Tissue Sarcoma
C4020753 BXGD020477 Intimal fibrosis
C4048329 BXGD021904 Immunosuppression
C4280802 BXGD022406 Pulmonary venous occlusion
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722524 BXGD023807 Blood Vessel Tumors Neoplasms
C4733095 BXGD023910 HER2-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein