Showing entry for Serine/threonine-protein kinase ICK


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021804
Protein NameSerine/threonine-protein kinase ICK
Uniport IdQ9UPZ9
GeneCILK1
Gene Id22858
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060271 cilium assembly
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0035720 intraciliary anterograde transport
Biological Process GO:0035721 intraciliary retrograde transport
Biological Process GO:0042073 intraciliary transport
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0004707 MAP kinase activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0036064 ciliary basal body
cellular component GO:0097546 ciliary base
cellular component GO:0097542 ciliary tip
cellular component GO:0005929 cilium
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0001650 fibrillar center
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001430 BXGD000054 Adenoma Neoplasms
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007104 BXGD000427 Female Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024809 BXGD001808 Marijuana Abuse Chemically-Induced Disorders; Mental Disorders
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0025995 BXGD001885 Micromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026633 BXGD001910 Mouth Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0027443 BXGD001992 Natal Teeth
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036996 BXGD002655 Short Rib-Polydactyly Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039075 BXGD002788 Syndactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0079541 BXGD003081 Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220697 BXGD004324 POLYDACTYLY, POSTAXIAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220810 BXGD004346 Congenital defects
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235653 BXGD004762 Malignant neoplasm of female breast Neoplasms; Skin and Connective Tissue Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239234 BXGD004974 Low set ears
C0240701 BXGD005050 Small penis
C0241521 BXGD005101 Ulnar deviation of hand Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264172 BXGD005371 Barrel chest Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0271093 BXGD006162 Stargardt's disease
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0333113 BXGD006923 Sacculation Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0334586 BXGD007126 Pleomorphic Xanthoastrocytoma Neoplasms
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0345354 BXGD007728 Radial polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0426790 BXGD008577 Narrow thorax
C0431388 BXGD008682 Microdysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0431659 BXGD008699 Hypoplasia of scrotum
C0483368 BXGD009016 Human anaplasmosis due to Anaplasma phagocytophilum Infections; Animal Diseases
C0497202 BXGD009055 Abnormal ocular motility
C0542518 BXGD009278 Enlarged kidney
C0549306 BXGD009368 Mesomelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679395 BXGD009769 vascular ischemia Pathological Conditions, Signs and Symptoms
C0679427 BXGD009777 myeloblastosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0855090 BXGD011070 B-cell lymphoma refractory Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0857379 BXGD011148 Abnormality of the pinna
C0869083 BXGD011303 Other specified congenital malformation syndromes, not elsewhere classified in ICD10CM
C0878659 BXGD011380 Disproportionate short stature Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1827301 BXGD013769 Extensively Drug-Resistant Tuberculosis Infections
C1827524 BXGD013773 Wide spaced nipples
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1834124 BXGD013956 Shield chest
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1840069 BXGD014433 Sandal gap
C1846131 BXGD014783 Photosensitive tonic-clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1846223 BXGD014792 Adrenal hypoplasia
C1847164 BXGD014854 Morning myoclonic jerks Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1849367 BXGD015046 Nasal bridge wide
C1853242 BXGD015322 Midface retrusion
C1858085 BXGD015770 Malar flattening
C1859717 BXGD015924 Depressed nasal tip
C1859844 BXGD015935 LEBER CONGENITAL AMAUROSIS, TYPE II (disorder) Eye Diseases
C1861866 BXGD016087 Aplasia/Hypoplasia of the corpus callosum
C1866129 BXGD016375 Abnormality of the cerebellum Nervous System Diseases
C1866730 BXGD016419 Rhizomelia
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675227 BXGD017281 Endocrine-Cerebroosteodysplasia Nervous System Diseases; Endocrine System Diseases
C2981150 BXGD018211 Uranostaphyloschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3275899 BXGD018679 Hyperechogenic kidneys
C3278923 BXGD018748 Dilated ventricles (finding)
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3899645 BXGD020087 Childhood Pleomorphic Xanthoastrocytoma
C4021757 BXGD020760 EEG with polyspike wave complexes
C4021759 BXGD020762 Generalized myoclonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4022995 BXGD021056 Sex reversal
C4048199 BXGD021893 Ulnar deviation of the hand or of fingers of the hand
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4289580 BXGD022491 Epithelioid glioblastoma
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4509819 BXGD022977 Endocrine-cerebro-osteodysplasia syndrome Musculoskeletal Diseases
C4693613 BXGD023609 EPILEPSY, JUVENILE MYOCLONIC, SUSCEPTIBILITY TO, 10
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein