Showing entry for Properdin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025485
Protein NameProperdin
Uniport IdP27918
GeneCFP
Gene Id5199
DomainTSP_1
Pfam PF00090  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006956 complement activation
Biological Process GO:0006957 complement activation, alternative pathway
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0006955 immune response
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0030449 regulation of complement activation
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0035580 specific granule lumen
cellular component GO:1904724 tertiary granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-166658 Complement cascade
R-HSA-166663 Initial triggering of complement
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-173736 Alternative complement activation
R-HSA-174577 Activation of C3 and C5
R-HSA-3781865 Diseases of glycosylation
R-HSA-3906995 Diseases associated with O-glycosylation of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173105 O-linked glycosylation
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins
R-HSA-5668914 Diseases of metabolism
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
R-HSA-977606 Regulation of Complement cascade
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016065 BXGD001046 Polyostotic fibrous dysplasia Musculoskeletal Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020175 BXGD001362 Hunger Behavior and Behavior Mechanisms
C0020624 BXGD001450 Hypomenorrhea Pathological Conditions, Signs and Symptoms
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023343 BXGD001635 Leprosy Infections
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025294 BXGD001854 Meningococcal meningitis Infections; Nervous System Diseases
C0025303 BXGD001858 Meningococcal Infections Infections
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041326 BXGD002915 Pleural Tuberculosis Infections; Respiratory Tract Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042693 BXGD002996 Violence
C0151332 BXGD003415 Active tuberculosis Infections
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0221239 BXGD004416 Rapidly progressive glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0233477 BXGD004581 Dysphoric mood Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233762 BXGD004610 Hallucinations, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0236663 BXGD004817 Alcohol withdrawal syndrome Chemically-Induced Disorders; Mental Disorders
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0240602 BXGD005046 opioid use
C0242292 BXGD005146 McCune-Albright Syndrome Musculoskeletal Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0259779 BXGD005218 Fibrous Dysplasia
C0268647 BXGD006024 Lysinuric Protein Intolerance Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0272242 BXGD006330 Complement deficiency disease Immune System Diseases; Hemic and Lymphatic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349251 BXGD007897 Behavioral syndrome associated with physiological disturbance and physical factors Mental Disorders
C0398762 BXGD008226 Properdin deficiency disease
C0409326 BXGD008379 Anterior knee pain
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432215 BXGD008739 Progressive pseudorheumatoid dysplasia Musculoskeletal Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596344 BXGD009643 clinical anxiety Mental Disorders
C0600104 BXGD009690 Obsessive compulsive behavior Behavior and Behavior Mechanisms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679362 BXGD009767 Tuberculosis, extrapulmonary Infections
C0747845 BXGD010184 early pregnancy
C0848332 BXGD010879 Spots on skin Skin and Connective Tissue Diseases
C0860603 BXGD011236 Anxiety symptoms
C1135745 BXGD011696 Meningitis, Meningococcal, Serogroup A Infections; Nervous System Diseases
C1135746 BXGD011697 Meningitis, Meningococcal, Serogroup B Infections; Nervous System Diseases
C1135747 BXGD011698 Meningitis, Meningococcal, Serogroup C Infections; Nervous System Diseases
C1136209 BXGD011713 Meningitis, Meningococcal, Serogroup Y Infections; Nervous System Diseases
C1136210 BXGD011714 Meningitis, Meningococcal, Serogroup W-135 Infections; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1331541 BXGD012480 Thymic Dysplasia
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1609538 BXGD013444 Latent Tuberculosis Infections
C1839454 BXGD014375 PROPERDIN DEFICIENCY, X-LINKED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C1839455 BXGD014376 Properdin Deficiency, Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C1839456 BXGD014377 Properdin Deficiency, Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C1839458 BXGD014378 Dysfunctional alternative complement pathway
C1845977 BXGD014769 X- linked recessive
C1853926 BXGD015365 NONAKA MYOPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2919706 BXGD017877 Idiopathic rapidly progressive glomerulonephritis
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4048329 BXGD021904 Immunosuppression
C4087273 BXGD022140 C3 glomerulopathy
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein