Showing entry for Potassium channel subfamily K member 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025486
Protein NamePotassium channel subfamily K member 3
Uniport IdO14649
GeneKCNK3
Gene Id3777
DomainIon_trans_2
Pfam PF07885  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007420 brain development
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0071294 cellular response to zinc ion
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0090102 cochlea development
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0006813 potassium ion transport
Biological Process GO:0042493 response to drug
Biological Process GO:0030322 stabilization of membrane potential
molecular function GO:0005216 ion channel activity
molecular function GO:0005252 open rectifier potassium channel activity
molecular function GO:0005267 potassium channel activity
molecular function GO:0022841 potassium ion leak channel activity
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0044548 S100 protein binding
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296346 Tandem pore domain potassium channels
R-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK)
R-HSA-397014 Muscle contraction
R-HSA-5576886 Phase 4 - resting membrane potential
R-HSA-5576891 Cardiac conduction
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0001726 BXGD000072 Affective Symptoms Behavior and Behavior Mechanisms
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011053 BXGD000694 Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015826 BXGD001022 Fenestration (morphologic abnormality)
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018834 BXGD001238 Heartburn Pathological Conditions, Signs and Symptoms
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028960 BXGD002101 Oligospermia Male Urogenital Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0031030 BXGD002272 Periapical Periodontitis Stomatognathic Diseases
C0034091 BXGD002463 Pulmonary Veno-Occlusive Disease (disorder) Respiratory Tract Diseases; Cardiovascular Diseases
C0035828 BXGD002566 Romano-Ward Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0039445 BXGD002810 Hereditary hemorrhagic telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0162770 BXGD003980 Right Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178272 BXGD004022 Disorder of pulmonary circulation Respiratory Tract Diseases; Cardiovascular Diseases
C0202194 BXGD004081 Potassium measurement
C0206525 BXGD004179 Tuberculosis, Drug-Resistant Infections
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0332853 BXGD006901 Anastomosis
C0340543 BXGD007344 Familial primary pulmonary hypertension Respiratory Tract Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0428886 BXGD008640 Mean blood pressure
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0694539 BXGD009849 Chronic atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0742034 BXGD010052 cerebellar function
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0871470 BXGD011316 Systolic Pressure
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1141890 BXGD011721 Congenital long QT syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1150929 BXGD011768 2-oxo-hept-3-ene-1,7-dioate hydratase activity
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306620 BXGD012371 Systolic blood pressure measurement
C1384514 BXGD012940 Conn Syndrome Endocrine System Diseases
C1611743 BXGD013456 Familial (FPAH)
C1701938 BXGD013524 Associated Pulmonary Arterial Hypertension Respiratory Tract Diseases
C1701939 BXGD013525 Familial pulmonary arterial hypertension
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1867423 BXGD016452 Increased pulmonary vascular resistance
C1969342 BXGD016771 PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED Respiratory Tract Diseases
C1969343 BXGD016772 Pulmonary Hypertension, Primary, Fenfluramine-Associated Respiratory Tract Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3714844 BXGD019435 Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia Respiratory Tract Diseases
C3809198 BXGD019575 PULMONARY HYPERTENSION, PRIMARY, 4
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3887640 BXGD019908 Astrocytosis Pathological Conditions, Signs and Symptoms
C3887658 BXGD019913 PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT Respiratory Tract Diseases; Cardiovascular Diseases
C4024896 BXGD021461 Motor neuron atrophy
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4054188 BXGD021977 Ph-Like Acute Lymphoblastic Leukemia
C4317009 BXGD022717 Diverticular Diseases Digestive System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551647 BXGD023381 Long QT Syndrome 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4552070 BXGD023481 Pulmonary Hypertension, Primary, 1 Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002591 Potassium 39.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein