Showing entry for Coagulation factor XIII A chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005552
Protein NameCoagulation factor XIII A chain
Uniport IdP00488
GeneF13A1
Gene Id2162
DomainTransglut_C; Transglut_core; Transglut_N
Pfam PF00927   PF01841   PF00868  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0072378 blood coagulation, fibrin clot formation
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0018149 peptide cross-linking
Biological Process GO:0002576 platelet degranulation
molecular function GO:0046872 metal ion binding
molecular function GO:0003810 protein-glutamine gamma-glutamyltransferase activity
cellular component GO:0072562 blood microparticle
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005576 extracellular region
cellular component GO:0031093 platelet alpha granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-168256 Immune System
R-HSA-449147 Signaling by Interleukins
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002991 BXGD000167 Cutaneous Fibrous Histiocytoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0012739 BXGD000786 Disseminated Intravascular Coagulation Hemic and Lymphatic Diseases
C0013491 BXGD000847 Ecchymosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0015530 BXGD001002 Hereditary Factor XIII Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016085 BXGD001047 Filariasis Infections
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0018924 BXGD001249 Hemarthrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023223 BXGD001621 Leg Ulcer Skin and Connective Tissue Diseases
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025323 BXGD001864 Menorrhagia Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028259 BXGD002073 Nodule
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032797 BXGD002373 Postpartum Hemorrhage Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038358 BXGD002748 Gastric ulcer Digestive System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040038 BXGD002837 Thromboembolism Cardiovascular Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0042344 BXGD002976 Varicose Ulcer Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0042485 BXGD002985 Venous Insufficiency Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151699 BXGD003461 Intracranial Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0151945 BXGD003508 Thrombosis of cerebral veins Nervous System Diseases; Cardiovascular Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162820 BXGD003985 Dermatitis, Allergic Contact Skin and Connective Tissue Diseases; Immune System Diseases
C0201278 BXGD004047 Antibody measurement (procedure)
C0206684 BXGD004239 Sebaceous Adenocarcinoma Neoplasms
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240412 BXGD005034 Muscle hematoma Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0269855 BXGD006060 Hematoma of cord Pathological Conditions, Signs and Symptoms
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0272350 BXGD006354 Dysfibrinogenemia, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392663 BXGD008061 Infection by Wuchereria bancrofti Infections; Hemic and Lymphatic Diseases
C0392784 BXGD008069 Dermatofibrosarcoma Protuberans Neoplasms
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0578878 BXGD009554 Inflammation of large intestine Digestive System Diseases
C0584960 BXGD009579 Factor V Leiden mutation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0751356 BXGD010406 Idiopathic Inflammatory Myopathies Musculoskeletal Diseases; Nervous System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1167912 BXGD011778 Coagulation factor measurement
C1269955 BXGD012005 Tumor Cell Invasion
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1697453 BXGD013507 Spontaneous hematomas
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1832662 BXGD013867 MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1837352 BXGD014223 Childhood onset
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1844374 BXGD014626 Persistent bleeding after trauma
C1851789 BXGD015233 Poor wound healing
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1969572 BXGD016781 Prolonged bleeding after dental extraction
C2239219 BXGD016966 von Willebrand's factor (lab test)
C2750514 BXGD017669 Factor Xiii, A Subunit, Deficiency Of Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2825741 BXGD017774 Indeterminate dendritic cell tumor Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2981150 BXGD018211 Uranostaphyloschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3160733 BXGD018471 THROMBOPHILIA DUE TO THROMBIN DEFECT
C3279439 BXGD018757 Recurrent spontaneous abortion Female Urogenital Diseases and Pregnancy Complications
C3550150 BXGD019132 Recurrent thrombophlebitis Cardiovascular Diseases
C3693482 BXGD019337 Giant Cell Fibroblastoma Neoplasms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021646 BXGD020717 Prolonged bleeding after surgery
C4022608 BXGD020936 Oral cavity bleeding
C4022611 BXGD020938 Prolonged bleeding following circumcision
C4023143 BXGD021122 Bleeding with minor or no trauma
C4023145 BXGD021123 Abnormal umbilical stump bleeding
C4024692 BXGD021371 Reduced factor XIII activity
C4280712 BXGD022390 Delayed onset bleeding
C4316906 BXGD022712 Factor XIII deficiency disease
C4321245 BXGD022744 Cleft lip or lips
C4511230 BXGD022997 Bathing suit ichthyosis
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002708 Strontium 87.62
BXGC0003705 Chloride 35.45
BXGC0023687 (S)-(+)-1,2-Propanediol 76.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein