Showing entry for Homeobox protein Meis2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004095
Protein NameHomeobox protein Meis2
Uniport IdO14770
GeneMEIS2
Gene Id4212
DomainHomeobox_KN; Meis_PKNOX_N
Pfam PF05920   PF16493  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0007420 brain development
Biological Process GO:0009880 embryonic pattern specification
Biological Process GO:0001654 eye development
Biological Process GO:0045638 negative regulation of myeloid cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0031016 pancreas development
Biological Process GO:0110024 positive regulation of cardiac muscle myoblast proliferation
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045931 positive regulation of mitotic cell cycle
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0070848 response to growth factor
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0008542 visual learning
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0008134 transcription factor binding
cellular component GO:0000790 nuclear chromatin
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002438 BXGD000113 Amebiasis Infections
C0003492 BXGD000198 Aortic coarctation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006325 BXGD000393 Bruxism Stomatognathic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013370 BXGD000822 Amebic colitis Digestive System Diseases; Infections
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018816 BXGD001234 Heart Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0042834 BXGD003004 Vital capacity
C0205682 BXGD004105 Waist-Hip Ratio
C0239234 BXGD004974 Low set ears
C0240538 BXGD005041 Convex nasal ridge
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0264303 BXGD005379 Laryngomalacia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0265449 BXGD005535 Pallister-Killian syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426891 BXGD008595 Broad thumbs
C0428791 BXGD008635 Aortic valve calcification Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0741916 BXGD010044 Cardiac defects
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1142533 BXGD011758 Smooth philtrum
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1832446 BXGD013844 Sparse eyebrow
C1832950 BXGD013889 Cardiac Malformation, Cleft Lip-Palate, Microcephaly and Digital Anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C1836047 BXGD014074 Long face
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1839758 BXGD014402 Narrow forehead
C1839767 BXGD014404 Tented upper lip vermilion
C1839783 BXGD014407 Large forehead
C1840069 BXGD014433 Sandal gap
C1842878 BXGD014543 Short 5th finger
C1844505 BXGD014633 Pointed chin
C1854113 BXGD015382 Prominent nasal bridge
C1854418 BXGD015402 Biparietal narrowing
C1861324 BXGD016029 Short philtrum
C1861921 BXGD016093 Cutaneous syndactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862142 BXGD016107 Short 2nd finger
C1865014 BXGD016282 Long philtrum
C1867131 BXGD016440 Broad hallux
C1868571 BXGD016508 Highly arched eyebrow
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2919142 BXGD017867 Short Stature, CTCAE
C2981150 BXGD018211 Uranostaphyloschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3276036 BXGD018682 High anterior hairline
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021813 BXGD020799 Oral cleft
C4023451 BXGD021190 Laterally extended eyebrow
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4225666 BXGD022287 CHROMOSOME 15q14 DELETION SYNDROME
C4551570 BXGD023357 2-3 toe syndactyly
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein