Showing entry for Delta-aminolevulinic acid dehydratase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007948
Protein NameDelta-aminolevulinic acid dehydratase
Uniport IdP13716
GeneALAD
Gene Id210
DomainALAD
Pfam PF00490  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00860 Porphyrin and chlorophyll metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071353 cellular response to interleukin-4
Biological Process GO:0071284 cellular response to lead ion
Biological Process GO:0006783 heme biosynthetic process
Biological Process GO:1901799 negative regulation of proteasomal protein catabolic process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0006782 protoporphyrinogen IX biosynthetic process
Biological Process GO:0014823 response to activity
Biological Process GO:0010044 response to aluminum ion
Biological Process GO:0043200 response to amino acid
Biological Process GO:0046685 response to arsenic-containing substance
Biological Process GO:0046686 response to cadmium ion
Biological Process GO:0032025 response to cobalt ion
Biological Process GO:0042493 response to drug
Biological Process GO:0045471 response to ethanol
Biological Process GO:0070542 response to fatty acid
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0009635 response to herbicide
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0010212 response to ionizing radiation
Biological Process GO:0010039 response to iron ion
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0046689 response to mercury ion
Biological Process GO:0051597 response to methylmercury
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0070541 response to platinum ion
Biological Process GO:0010269 response to selenium ion
Biological Process GO:0010266 response to vitamin B1
Biological Process GO:0033197 response to vitamin E
Biological Process GO:0010043 response to zinc ion
molecular function GO:0003824 catalytic activity
molecular function GO:0042802 identical protein binding
molecular function GO:0004655 porphobilinogen synthase activity
molecular function GO:1904854 proteasome core complex binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005634 nucleus
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-189445 Metabolism of porphyrins
R-HSA-189451 Heme biosynthesis
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017638 BXGD001132 Glioma Neoplasms
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0018989 BXGD001263 Hemiparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0018995 BXGD001265 Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022333 BXGD001534 Jacksonian Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023176 BXGD001612 Lead Poisoning Chemically-Induced Disorders
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030779 BXGD002252 Pelger-Huet Anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0031572 BXGD002307 Phobia, Social Mental Disorders
C0032463 BXGD002357 Polycythemia Vera Neoplasms; Hemic and Lymphatic Diseases
C0032708 BXGD002368 Disorders of Porphyrin Metabolism Nutritional and Metabolic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035232 BXGD002517 Respiratory Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0162533 BXGD003952 Porphyrias, Hepatic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162565 BXGD003957 Acute intermittent porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0205834 BXGD004131 Meningiomas, Multiple Neoplasms; Nervous System Diseases
C0232488 BXGD004547 Abdominal colic Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0233401 BXGD004575 Psychiatric symptom
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535 BXGD004688 Clonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240602 BXGD005046 opioid use
C0259785 BXGD005222 Malignant Meningioma Neoplasms; Nervous System Diseases
C0268328 BXGD005898 Porphobilinogen synthase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0268490 BXGD005962 Tyrosinemia, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0270549 BXGD006079 Generalized Anxiety Disorder Mental Disorders
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844 BXGD006115 Tonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0281784 BXGD006785 Benign Meningioma Neoplasms; Nervous System Diseases
C0311375 BXGD006883 Arsenic Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0334605 BXGD007133 Meningothelial meningioma Neoplasms; Nervous System Diseases
C0334606 BXGD007134 Fibrous Meningioma Neoplasms; Nervous System Diseases
C0334607 BXGD007135 Psammomatous Meningioma Neoplasms; Nervous System Diseases
C0334608 BXGD007136 Angiomatous Meningioma Neoplasms; Nervous System Diseases
C0334609 BXGD007137 Hemangioblastic Meningioma Neoplasms; Nervous System Diseases
C0334610 BXGD007138 Hemangiopericytic Meningioma Neoplasms; Nervous System Diseases
C0334611 BXGD007139 Transitional Meningioma Neoplasms; Nervous System Diseases
C0347515 BXGD007858 Spinal Meningioma Neoplasms; Nervous System Diseases
C0349604 BXGD007934 Intracranial Meningioma Neoplasms; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0422850 BXGD008457 Seizures, Somatosensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852 BXGD008458 Seizures, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853 BXGD008459 Olfactory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854 BXGD008460 Gustatory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855 BXGD008461 Vertiginous seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0431121 BXGD008661 Clear Cell Meningioma Neoplasms; Nervous System Diseases
C0457190 BXGD008886 Xanthomatous Meningioma Neoplasms; Nervous System Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677050 BXGD009714 Manganese Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751056 BXGD010306 Non-epileptic convulsion Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110 BXGD010318 Single Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123 BXGD010326 Atonic Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751303 BXGD010385 Cerebral Convexity Meningioma Neoplasms; Nervous System Diseases
C0751304 BXGD010386 Parasagittal Meningioma Neoplasms; Nervous System Diseases
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496 BXGD010474 Seizures, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751569 BXGD010504 Genitourinary Cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751859 BXGD010616 Lead Poisoning, Nervous System Nervous System Diseases; Chemically-Induced Disorders
C1264195 BXGD011913 Refractory anemia with ringed sideroblasts Hemic and Lymphatic Diseases
C1266042 BXGD011938 Chromophobe Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266043 BXGD011939 Sarcomatoid Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266044 BXGD011940 Collecting Duct Carcinoma of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1334261 BXGD012691 Intraorbital Meningioma Neoplasms; Nervous System Diseases
C1334271 BXGD012693 Intraventricular Meningioma Neoplasms; Nervous System Diseases
C1335107 BXGD012760 Olfactory Groove Meningioma Neoplasms; Nervous System Diseases
C1384406 BXGD012937 Secretory meningioma Neoplasms; Nervous System Diseases
C1384408 BXGD012938 Microcystic meningioma Neoplasms; Nervous System Diseases
C1527197 BXGD013259 Angioblastic Meningioma Neoplasms; Nervous System Diseases
C1527390 BXGD013285 Neoplasms, Intracranial Neoplasms; Nervous System Diseases
C1565950 BXGD013406 Posterior Fossa Meningioma Neoplasms; Nervous System Diseases
C1565951 BXGD013407 Sphenoid Wing Meningioma Neoplasms; Nervous System Diseases
C1848702 BXGD014968 Elevated urinary delta-aminolevulinic acid
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2748608 BXGD017602 LEAD POISONING, SUSCEPTIBILITY TO
C2749625 BXGD017629 Motor axonal neuropathy
C3163622 BXGD018514 Papillary Meningioma Neoplasms; Nervous System Diseases
C3469186 BXGD018909 HEMOCHROMATOSIS, TYPE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3495874 BXGD019008 Nonepileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3714514 BXGD019409 Infection Infections
C4016013 BXGD020256 PORPHYRIA, ACUTE HEPATIC, DIGENIC
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436 BXGD022962 Generalized Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002439 4-Oxopentanoic acid 116.12
BXGC0012311 5-Aminolevulinic acid 131.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein