protein

Showing entry for Follistatin

General Target Information
BXGT Id	BXGT008528
Protein Name	Follistatin
Uniport Id	P19883
Gene	FST
Gene Id	10468
Domain	FOLN; Kazal_2
Pfam	PF09289 PF07648
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.2 Signal transduction	hsa04350	TGF-beta signaling pathway

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0030509	BMP signaling pathway
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0008585	female gonad development
Biological Process	GO:0007276	gamete generation
Biological Process	GO:0031069	hair follicle morphogenesis
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation
Biological Process	GO:0043616	keratinocyte proliferation
Biological Process	GO:0007275	multicellular organism development
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway
Biological Process	GO:0045596	negative regulation of cell differentiation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth
Biological Process	GO:0007389	pattern specification process
Biological Process	GO:0051798	positive regulation of hair follicle development
Biological Process	GO:0030510	regulation of BMP signaling pathway
Biological Process	GO:0001501	skeletal system development
molecular function	GO:0048185	activin binding
molecular function	GO:0038102	activin receptor antagonist activity
molecular function	GO:0043395	heparan sulfate proteoglycan binding
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005576	extracellular region
cellular component	GO:0005615	extracellular space
cellular component	GO:0005634	nucleus

Reactome

Pathway Id	Pathway Name
R-HSA-1502540	Signaling by Activin
R-HSA-162582	Signal Transduction
R-HSA-2473224	Antagonism of Activin by Follistatin
R-HSA-9006936	Signaling by TGFB family members

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000768	BXGD000007	Congenital Abnormality	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000786	BXGD000010	Spontaneous abortion	Female Urogenital Diseases and Pregnancy Complications
C0000822	BXGD000012	Abortion, Tubal	Female Urogenital Diseases and Pregnancy Complications
C0001430	BXGD000054	Adenoma	Neoplasms
C0002965	BXGD000162	Angina, Unstable	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003469	BXGD000195	Anxiety Disorders	Mental Disorders
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0004941	BXGD000296	Behavioral Symptoms	Behavior and Behavior Mechanisms
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006145	BXGD000376	Breast Diseases	Skin and Connective Tissue Diseases
C0006625	BXGD000401	Cachexia	Pathological Conditions, Signs and Symptoms
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007124	BXGD000437	Noninfiltrating Intraductal Carcinoma	Neoplasms
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0007370	BXGD000462	Catalepsy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008497	BXGD000549	Choriocarcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0010674	BXGD000683	Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0010692	BXGD000686	Cystitis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013264	BXGD000808	Muscular Dystrophy, Duchenne	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0014170	BXGD000902	Endometrial Neoplasms	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0017601	BXGD001125	Glaucoma	Eye Diseases
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0018206	BXGD001186	granulosa cell tumor	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0018939	BXGD001253	Hematological Disease	Hemic and Lymphatic Diseases
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0021390	BXGD001503	Inflammatory Bowel Diseases	Digestive System Diseases
C0022408	BXGD001544	Arthropathy	Musculoskeletal Diseases
C0023267	BXGD001626	Fibroid Tumor	Neoplasms
C0023418	BXGD001642	leukemia	Neoplasms
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0023896	BXGD001718	Alcoholic Liver Diseases	Digestive System Diseases; Chemically-Induced Disorders
C0023903	BXGD001720	Liver neoplasms	Digestive System Diseases; Neoplasms
C0024031	BXGD001727	Low Back Pain	Pathological Conditions, Signs and Symptoms
C0024115	BXGD001732	Lung diseases	Respiratory Tract Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0025202	BXGD001832	melanoma	Neoplasms
C0025289	BXGD001851	Meningitis	Nervous System Diseases
C0025295	BXGD001855	Meningitis, Pneumococcal	Infections; Nervous System Diseases
C0025322	BXGD001863	Premature Menopause	Female Urogenital Diseases and Pregnancy Complications
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0025874	BXGD001880	Metrorrhagia	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026847	BXGD001940	Spinal Muscular Atrophy	Nervous System Diseases
C0026848	BXGD001941	Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C0026850	BXGD001942	Muscular Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027819	BXGD002043	Neuroblastoma	Neoplasms
C0027868	BXGD002053	Neuromuscular Diseases	Nervous System Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029191	BXGD002122	Orchitis	Male Urogenital Diseases; Endocrine System Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029422	BXGD002142	Osteochondrodysplasias	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0034069	BXGD002458	Pulmonary Fibrosis	Respiratory Tract Diseases
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0038356	BXGD002747	Stomach Neoplasms	Digestive System Diseases; Neoplasms
C0038436	BXGD002755	Post-Traumatic Stress Disorder	Mental Disorders
C0040100	BXGD002840	Thymoma	Neoplasms; Hemic and Lymphatic Diseases
C0041956	BXGD002942	Ureteral obstruction	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042133	BXGD002960	Uterine Fibroids	Neoplasms
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085215	BXGD003141	Ovarian Failure, Premature	Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151514	BXGD003429	Atrophic condition of skin	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0153676	BXGD003679	Secondary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0156344	BXGD003851	Endometriosis of ovary	Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0162557	BXGD003956	Liver Failure, Acute	Digestive System Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0206650	BXGD004214	Fibroadenoma	Neoplasms
C0206664	BXGD004226	Teratocarcinoma	Neoplasms
C0220620	BXGD004299	Gastrointestinal Carcinoid Tumor	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0235989	BXGD004801	Renal interstitial fibrosis	Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0238288	BXGD004905	Muscular Dystrophy, Facioscapulohumeral	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0269102	BXGD006053	Endometrioma	Female Urogenital Diseases and Pregnancy Complications
C0278488	BXGD006515	Carcinoma breast stage IV
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0332840	BXGD006900	Amputated structure (morphologic abnormality)	Wounds and Injuries
C0339527	BXGD007260	Leber Congenital Amaurosis	Eye Diseases
C0341106	BXGD007389	Eosinophilic esophagitis	Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0345904	BXGD007745	Malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0362046	BXGD007959	Prediabetes syndrome	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0406585	BXGD008353	Lethal tight skin contracture syndrome (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0409959	BXGD008400	Osteoarthritis, Knee	Musculoskeletal Diseases
C0410528	BXGD008430	Skeletal dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0476089	BXGD008977	Endometrial Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0494165	BXGD009022	Secondary malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935	BXGD009674	Tumor Initiation	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600041	BXGD009685	Infective cystitis	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0686353	BXGD009833	Muscular Dystrophies, Limb-Girdle	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0700095	BXGD009875	Central neuroblastoma	Neoplasms; Nervous System Diseases
C0747845	BXGD010184	early pregnancy
C0751713	BXGD010564	Inclusion Body Myopathy, Sporadic	Musculoskeletal Diseases; Nervous System Diseases
C0751967	BXGD010657	Multiple Sclerosis, Relapsing-Remitting	Immune System Diseases; Nervous System Diseases
C0812413	BXGD010847	Malignant Pleural Mesothelioma	Neoplasms; Respiratory Tract Diseases
C0853879	BXGD010982	Invasive carcinoma of breast	Neoplasms; Skin and Connective Tissue Diseases
C0856825	BXGD011118	Acute GVH disease	Immune System Diseases
C0858252	BXGD011172	Breast adenocarcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0917713	BXGD011404	Becker Muscular Dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0920646	BXGD011471	Ischemia of kidney	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1134719	BXGD011688	Invasive Ductal Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1153706	BXGD011769	Endometrial adenocarcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1257931	BXGD011815	Mammary Neoplasms, Human	Neoplasms; Skin and Connective Tissue Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1275126	BXGD012062	TNF receptor-associated periodic fever syndrome (TRAPS)	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1301797	BXGD012299	Induced hypothermia (finding)	Pathological Conditions, Signs and Symptoms
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1328252	BXGD012460	Mucocutaneous leishmaniasis	Infections; Skin and Connective Tissue Diseases
C1368683	BXGD012900	Epithelioma	Neoplasms
C1370419	BXGD012910	Ovarian Granulosa Cell Tumor	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1391732	BXGD012971	Cancer cachexia
C1442837	BXGD013060	Myocardial necrosis	Cardiovascular Diseases
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1512409	BXGD013188	Hepatocarcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C1519670	BXGD013241	Tumor Angiogenesis	Pathological Conditions, Signs and Symptoms
C1536148	BXGD013338	Chocolate cyst of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1536220	BXGD013341	ST segment elevation myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1623038	BXGD013475	Cirrhosis	Pathological Conditions, Signs and Symptoms
C1704272	BXGD013537	Benign Prostatic Hyperplasia	Male Urogenital Diseases
C1708349	BXGD013597	Hereditary Diffuse Gastric Cancer	Digestive System Diseases; Neoplasms
C1720983	BXGD013698	Channelopathies	Pathological Conditions, Signs and Symptoms
C1800706	BXGD013755	Idiopathic Pulmonary Fibrosis	Respiratory Tract Diseases
C1845050	BXGD014703	PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C1960398	BXGD016658	HER2-positive carcinoma of breast	Neoplasms; Skin and Connective Tissue Diseases
C1969372	BXGD016775	Tubulointerstitial fibrosis
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C3266262	BXGD018600	Multiple Chronic Conditions	Pathological Conditions, Signs and Symptoms
C3495436	BXGD018985	American cutaneous leishmaniasis	Infections; Skin and Connective Tissue Diseases
C3714636	BXGD019421	Pneumonitis	Infections; Respiratory Tract Diseases
C3811653	BXGD019662	Experimental Organism Basal Cell Carcinoma	Neoplasms
C3830362	BXGD019751	Early Pregnancy Loss	Female Urogenital Diseases and Pregnancy Complications
C4049392	BXGD021929	Chronic hepatitis C genotype 1
C4086165	BXGD022126	Childhood Neuroblastoma	Neoplasms
C4269195	BXGD022329	Chronic bladder pain
C4303510	BXGD022563	Idiopathic premature ovarian failure	Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4529962	BXGD023178	Fatty Liver Disease
C4552766	BXGD023523	Miscarriage	Female Urogenital Diseases and Pregnancy Complications
C4704874	BXGD023682	Mammary Carcinoma, Human	Neoplasms; Skin and Connective Tissue Diseases
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721806	BXGD023772	Carcinoma, Basal Cell	Neoplasms

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0006198	Citric acid		192.12

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}