Showing entry for E3 SUMO-protein ligase RanBP2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010743
Protein NameE3 SUMO-protein ligase RanBP2
Uniport IdP49792
GeneRANBP2
Gene Id5903
DomainIR1-M; Pro_isomerase; Ran_BP1; zf-RanBP
Pfam PF12185   PF00160   PF00638   PF00641  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03013 RNA transport
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051642 centrosome localization
Biological Process GO:0075733 intracellular transport of virus
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0006607 NLS-bearing protein import into nucleus
Biological Process GO:0033133 positive regulation of glucokinase activity
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0006457 protein folding
Biological Process GO:0000413 protein peptidyl-prolyl isomerization
Biological Process GO:0016925 protein sumoylation
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0060964 regulation of gene silencing by miRNA
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0006110 regulation of glycolytic process
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0006409 tRNA export from nucleus
Biological Process GO:0016032 viral process
Biological Process GO:0019083 viral transcription
molecular function GO:0046872 metal ion binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0008536 Ran GTPase binding
molecular function GO:0003723 RNA binding
molecular function GO:0019789 SUMO transferase activity
cellular component GO:0005642 annulate lamellae
cellular component GO:0005737 cytoplasm
cellular component GO:1990723 cytoplasmic periphery of the nuclear pore complex
cellular component GO:0005829 cytosol
cellular component GO:0043657 host cell
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005635 nuclear envelope
cellular component GO:0042405 nuclear inclusion body
cellular component GO:0031965 nuclear membrane
cellular component GO:0005643 nuclear pore
cellular component GO:0044614 nuclear pore cytoplasmic filaments
cellular component GO:0044615 nuclear pore nuclear basket
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-141424 Amplification of signal from the kinetochores
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-1430728 Metabolism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-162582 Signal Transduction
R-HSA-162587 HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168255 Influenza Infection
R-HSA-168256 Immune System
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194441 Metabolism of non-coding RNA
R-HSA-195258 RHO GTPase Effectors
R-HSA-211000 Gene Silencing by RNA
R-HSA-2262752 Cellular responses to stress
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-2990846 SUMOylation
R-HSA-2990846 SUMOylation
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5619102 SLC transporter disorders
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68875 Mitotic Prophase
R-HSA-68877 Mitotic Prometaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69618 Mitotic Spindle Checkpoint
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-72306 tRNA processing
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953854 Metabolism of RNA
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-913531 Interferon Signaling
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9610379 HCMV Late Events
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004565 BXGD000276 Melanoma, B16 Neoplasms
C0006114 BXGD000371 Cerebral Edema Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0008354 BXGD000533 Cholera Infections
C0008522 BXGD000553 Choroid Hemorrhage Pathological Conditions, Signs and Symptoms; Eye Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014059 BXGD000881 Encephalomyelitis, Acute Disseminated Immune System Diseases; Nervous System Diseases
C0014077 BXGD000889 Leukoencephalitis, Acute Hemorrhagic Immune System Diseases; Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0018199 BXGD001181 Granuloma, Plasma Cell Pathological Conditions, Signs and Symptoms
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0019270 BXGD001311 Hernia Pathological Conditions, Signs and Symptoms
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0023003 BXGD001597 Langer-Giedion Syndrome Musculoskeletal Diseases
C0023264 BXGD001625 Leigh Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023479 BXGD001663 Acute myelomonocytic leukemia Neoplasms
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026499 BXGD001905 Monosomy Pathological Conditions, Signs and Symptoms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032541 BXGD002359 Polyneuritis Nervous System Diseases
C0034372 BXGD002480 Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036396 BXGD002609 Sciatica Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036651 BXGD002628 Solar lentigo Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0038016 BXGD002727 Spondylolisthesis Musculoskeletal Diseases
C0038017 BXGD002728 Congenital spondylolisthesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0158252 BXGD003877 Intervertebral disc disorder Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0162835 BXGD003989 Hypopigmentation disorder Skin and Connective Tissue Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0221775 BXGD004480 Lumbar disc disease Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279627 BXGD006658 Adult Acute Myelomonocytic Leukemia Neoplasms
C0279644 BXGD006668 Childhood Acute Myelomonocytic Leukemia Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0334121 BXGD006996 Inflammatory Myofibroblastic Tumor Pathological Conditions, Signs and Symptoms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0410533 BXGD008433 Osteodysplasia
C0410632 BXGD008440 Schmorl's nodes Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0496836 BXGD009042 Malignant tumor of eye Neoplasms; Eye Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306587 BXGD012368 Acute encephalopathy Nervous System Diseases
C1318711 BXGD012405 Herpes simplex type 1 infection Infections; Skin and Connective Tissue Diseases
C1333967 BXGD012661 Inflammatory pseudotumor of liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1806780 BXGD013759 Increased CSF protein
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837388 BXGD014225 Abnormal pattern of respiration
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1855020 BXGD015451 Acute necrotizing encephalopathy
C1860823 BXGD016003 Trichorhinophalangeal Syndrome, Type III Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C1876214 BXGD016567 ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C2062441 BXGD016897 Influenza A
C2675556 BXGD017301 ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3714534 BXGD019411 dowling-degos disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021243 BXGD020593 Abnormality of thalamus morphology
C4022749 BXGD020980 Abnormal brainstem MRI signal intensity
C4329281 BXGD022785 Advanced Malignant Solid Neoplasm
C4477094 BXGD022921 Abnormal visual fixation
C4509836 BXGD022978 Familial acute necrotizing encephalopathy
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4706387 BXGD023690 Acute necrotizing encephalopathy of childhood
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4732790 BXGD023901 Abnormal putamen morphology
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000696 Tartaric acid 150.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein