protein

Showing entry for Anthrax toxin receptor 2

General Target Information
BXGT Id	BXGT011233
Protein Name	Anthrax toxin receptor 2
Uniport Id	P58335
Gene	ANTXR2
Gene Id	118429
Domain	Anth_Ig; Ant_C; VWA
Pfam	PF05586 PF05587 PF00092
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.1 Immune system	hsa04621	NOD-like receptor signaling pathway

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0022414	reproductive process
Biological Process	GO:1901998	toxin transport
molecular function	GO:0046872	metal ion binding
molecular function	GO:0004888	transmembrane signaling receptor activity
cellular component	GO:0009986	cell surface
cellular component	GO:0005789	endoplasmic reticulum membrane
cellular component	GO:0010008	endosome membrane
cellular component	GO:0009897	external side of plasma membrane
cellular component	GO:0005576	extracellular region
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001787	BXGD000076	Osteoporosis, Age-Related	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0003175	BXGD000187	Anthrax disease	Infections
C0003862	BXGD000230	Arthralgia	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006157	BXGD000377	Breech Presentation	Female Urogenital Diseases and Pregnancy Complications
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0008313	BXGD000528	Cholangitis, Sclerosing	Digestive System Diseases
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009917	BXGD000635	Contracture	Musculoskeletal Diseases
C0009918	BXGD000636	Contracture of joint	Musculoskeletal Diseases
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0013336	BXGD000815	Dwarfism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0015544	BXGD001003	Failure to Thrive	Pathological Conditions, Signs and Symptoms
C0016045	BXGD001037	fibroma	Neoplasms
C0016048	BXGD001038	Fibromatosis	Neoplasms
C0016049	BXGD001039	Fibromatosis, Gingival	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0017567	BXGD001119	Gingival Hypertrophy	Stomatognathic Diseases
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0017638	BXGD001132	Glioma	Neoplasms
C0019337	BXGD001319	Heroin Dependence	Chemically-Induced Disorders; Mental Disorders
C0019348	BXGD001325	Herpes Simplex Infections	Infections; Skin and Connective Tissue Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020615	BXGD001445	Hypoglycemia	Nutritional and Metabolic Diseases
C0020676	BXGD001462	Hypothyroidism	Endocrine System Diseases
C0021051	BXGD001475	Immunologic Deficiency Syndromes	Immune System Diseases
C0023508	BXGD001675	White Blood Cell Count procedure
C0023518	BXGD001677	Leukocytosis	Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0024236	BXGD001752	Lymphedema	Hemic and Lymphatic Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0025995	BXGD001885	Micromelia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026827	BXGD001936	Muscle hypotonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027404	BXGD001984	Narcolepsy	Nervous System Diseases; Mental Disorders
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0028259	BXGD002073	Nodule
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453	BXGD002154	Osteopenia	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459	BXGD002159	Osteoporosis, Senile	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0033860	BXGD002438	Psoriasis	Skin and Connective Tissue Diseases
C0037293	BXGD002684	Skin tag	Pathological Conditions, Signs and Symptoms; Neoplasms; Skin and Connective Tissue Diseases
C0037299	BXGD002685	Skin Ulcer	Skin and Connective Tissue Diseases
C0037822	BXGD002706	Speech Disorders	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038013	BXGD002725	Ankylosing spondylitis	Musculoskeletal Diseases
C0038238	BXGD002741	Steatorrhea	Digestive System Diseases; Nutritional and Metabolic Diseases
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0040427	BXGD002864	Tooth Abnormalities	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0040997	BXGD002894	Trigeminal Neuralgia	Nervous System Diseases; Stomatognathic Diseases
C0042109	BXGD002957	Urticaria	Skin and Connective Tissue Diseases; Immune System Diseases
C0079744	BXGD003090	Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151718	BXGD003464	Hypocholesterolemia	Nutritional and Metabolic Diseases
C0151811	BXGD003478	Subcutaneous nodule	Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0162298	BXGD003933	Joint stiffness	Musculoskeletal Diseases
C0162834	BXGD003988	Hyperpigmentation	Skin and Connective Tissue Diseases
C0200635	BXGD004041	Lymphocyte Count measurement
C0200638	BXGD004043	Eosinophil count procedure
C0205766	BXGD004118	Myxofibroma	Neoplasms
C0220613	BXGD004297	Adult Soft Tissue Sarcoma
C0220645	BXGD004307	Childhood Soft Tissue Sarcoma
C0221355	BXGD004447	Macrocephaly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221357	BXGD004449	Brachydactyly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0232466	BXGD004543	Feeding difficulties
C0239998	BXGD005012	Recurrent infections	Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0241165	BXGD005083	Thick skin
C0278152	BXGD006503	Hemifacial Spasm	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0332563	BXGD006894	Papule	Pathological Conditions, Signs and Symptoms
C0343641	BXGD007636	Human papilloma virus infection	Infections
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0349566	BXGD007928	Squamous cell carcinoma of tongue	Neoplasms; Stomatognathic Diseases
C0349588	BXGD007933	Short stature
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0376480	BXGD007998	Gingival Overgrowth	Stomatognathic Diseases
C0401151	BXGD008274	Chronic diarrhea	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0409338	BXGD008381	Flexion contracture - elbow
C0409346	BXGD008383	Contracture of joint of thumb	Musculoskeletal Diseases
C0409348	BXGD008384	Flexion contracture of proximal interphalangeal joint
C0454644	BXGD008850	Delayed speech and language development	Behavior and Behavior Mechanisms
C0521525	BXGD009139	Short neck
C0541794	BXGD009262	Skeletal muscle atrophy
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0701807	BXGD009901	Acute anterior uveitis	Eye Diseases
C0751406	BXGD010428	Post-Traumatic Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0836924	BXGD010864	Thrombocytosis	Hemic and Lymphatic Diseases
C0949690	BXGD011584	Spondylarthritis	Musculoskeletal Diseases
C1142533	BXGD011758	Smooth philtrum
C1167791	BXGD011776	Skin toxicity
C1260926	BXGD011844	Abnormal pigmentation
C1261473	BXGD011855	Sarcoma	Neoplasms
C1269955	BXGD012005	Tumor Cell Invasion
C1298820	BXGD012252	Aneurysm of aortic root	Cardiovascular Diseases
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1519353	BXGD013236	Skin Papule	Skin and Connective Tissue Diseases
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1658953	BXGD013486	tumor vasculature
C1833326	BXGD013914	Generalized bone demineralization
C1836542	BXGD014129	Depressed nasal bridge
C1837658	BXGD014257	Gross motor development delay	Mental Disorders
C1839739	BXGD014400	Thick lower lip vermilion
C1840077	BXGD014434	Anteverted nostril
C1842083	BXGD014494	Abnormality of the ribs
C1843108	BXGD014556	Short palm
C1844383	BXGD014628	Recurrent bacterial infection	Infections
C1844806	BXGD014676	Weight less than 3rd percentile
C1845847	BXGD014760	Coarse facial features	Pathological Conditions, Signs and Symptoms
C1846423	BXGD014812	Thick upper lip vermilion
C1849340	BXGD015039	Long palpebral fissure
C1858430	BXGD015792	Death in infancy
C1859212	BXGD015863	Limited neck range of motion
C1861172	BXGD016016	Venous Thromboembolism	Cardiovascular Diseases
C1861403	BXGD016045	Variable expressivity
C2315100	BXGD017021	Pediatric failure to thrive	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2745948	BXGD017569	Hyalinosis, Systemic	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2931822	BXGD018068	Nasopharyngeal carcinoma	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3279322	BXGD018752	Progressive flexion contractures
C3805574	BXGD019481	Increased fracture rate
C3887650	BXGD019911	Adult Rickets	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C3898127	BXGD020061	Non-Metastatic Childhood Soft Tissue Sarcoma
C4021787	BXGD020780	Abnormal diaphysis morphology
C4021794	BXGD020784	Abnormality of the adrenal glands
C4022018	BXGD020872	Telangiectasia of the skin	Cardiovascular Diseases
C4023528	BXGD021211	Abnormality of skin morphology	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4023588	BXGD021223	Abnormality of the gastrointestinal tract	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4023796	BXGD021264	Aplasia/Hypoplasia of the thymus
C4024737	BXGD021397	Aplasia/Hypoplasia of the skin
C4538570	BXGD023221	COMPLEMENT HYPERACTIVATION, ANGIOPATHIC THROMBOSIS, AND PROTEIN-LOSING ENTEROPATHY
C4551687	BXGD023392	Sarcoma of soft tissue	Neoplasms
C4721411	BXGD023735	Osteolysis	Musculoskeletal Diseases
C4728082	BXGD023886	Severe hypoglycaemia

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000061	Gallic acid 3-O-gallate		322.23
BXGC0000368	Gallic acid		170.12
BXGC0000369	Methyl gallate		184.15
BXGC0000504	Vanillic acid		168.15
BXGC0000505	Protocatechuic acid		154.12
BXGC0001857	Caffeic acid		180.16
BXGC0002588	Magnesium		24.31
BXGC0002690	alpha-Catechin		290.27
BXGC0004647	3-(3,4-Dihydroxyphenyl)propanoic acid		182.17
BXGC0005683	Quercetin		302.24
BXGC0005756	Propyl gallate		212.2
BXGC0005871	Dopamine		153.18
BXGC0006306	Myricetin		318.24
BXGC0009548	Epigallocatechin		306.27
BXGC0012913	Pentagalloyl Glucose		940.12
BXGC0013582	Curcumin		368.13
BXGC0019117	Tannic Acid		1700.17
BXGC0020412	Methyl Protocatechuate		168.04
BXGC0022876	6,8-Dihydroxy-3-Methylisocoumarin		192.04
BXGC0049447	acetate		59.01

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}