Showing entry for Triosephosphate isomerase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011294
Protein NameTriosephosphate isomerase
Uniport IdP60174
GeneTPI1
Gene Id7167
DomainTIM
Pfam PF00121  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00010 Glycolysis / Gluconeogenesis
1. Metabolism 1.1 Carbohydrate metabolism hsa00051 Fructose and mannose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0046166 glyceraldehyde-3-phosphate biosynthetic process
Biological Process GO:0019563 glycerol catabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0019242 methylglyoxal biosynthetic process
molecular function GO:0008929 methylglyoxal synthase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004807 triose-phosphate isomerase activity
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-70171 Glycolysis
R-HSA-70263 Gluconeogenesis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001787 BXGD000076 Osteoporosis, Age-Related Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002735 BXGD000126 Oppenheim's Disease Nervous System Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0002879 BXGD000138 Anemia, Hemolytic, Acquired Hemic and Lymphatic Diseases
C0002881 BXGD000140 Anemia, Hemolytic, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002882 BXGD000141 Anemia, Hemolytic, Congenital Nonspherocytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002889 BXGD000146 Anemia, Microangiopathic Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0008325 BXGD000529 Cholecystitis Digestive System Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010709 BXGD000689 Cyst Pathological Conditions, Signs and Symptoms; Neoplasms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011311 BXGD000714 Dengue Fever Infections
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0017536 BXGD001114 Giardiasis Digestive System Diseases; Infections
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018023 BXGD001164 Nodular Goiter Endocrine System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023529 BXGD001682 Leukomalacia, Periventricular Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025290 BXGD001852 Aseptic Meningitis Nervous System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026640 BXGD001912 Mouth Neoplasms Neoplasms; Stomatognathic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0028840 BXGD002089 Ocular Hypertension Eye Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459 BXGD002159 Osteoporosis, Senile Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030409 BXGD002217 Paracoccidioidomycosis Infections
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032231 BXGD002339 Pleurisy Infections; Respiratory Tract Diseases
C0033839 BXGD002434 Pseudorabies Infections; Nervous System Diseases; Animal Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035232 BXGD002517 Respiratory Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0039263 BXGD002805 Takayasu Arteritis Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0040558 BXGD002873 Toxoplasmosis Infections
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041234 BXGD002901 Chagas Disease Infections
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0085136 BXGD003131 Central Nervous System Neoplasms Neoplasms; Nervous System Diseases
C0085407 BXGD003167 Microsporidiosis Infections
C0085577 BXGD003189 Normocytic anemia Hemic and Lymphatic Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0221021 BXGD004368 Microangiopathic hemolytic anemia Hemic and Lymphatic Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233401 BXGD004575 Psychiatric symptom
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235983 BXGD004798 Normochromic anemia Hemic and Lymphatic Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0240421 BXGD005037 Progressive muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0275524 BXGD006376 Coinfection Infections
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0392702 BXGD008065 Abnormal involuntary movement Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0398562 BXGD008191 Triose phosphate isomerase deficiency
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0520572 BXGD009093 Enzymopathy Nutritional and Metabolic Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0546126 BXGD009328 Acute Confusional Senile Dementia Nervous System Diseases; Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0748355 BXGD010195 Acute respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0750900 BXGD010241 Alzheimer's Disease, Focal Onset Nervous System Diseases; Mental Disorders
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0751381 BXGD010421 Foley-Denny-Brown Syndrome Nervous System Diseases
C0751406 BXGD010428 Post-Traumatic Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0752251 BXGD010700 Muscle Disease Manifestations Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752252 BXGD010701 Neuromuscular Manifestations Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752304 BXGD010711 Hypoxic-Ischemic Encephalopathy Nervous System Diseases; Cardiovascular Diseases
C0752335 BXGD010720 Neuropsychiatric Systemic Lupus Erythematosus Infections; Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0796074 BXGD010793 MOHR-TRANEBJAERG SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Mental Disorders; Otorhinolaryngologic Diseases; Behavior and Behavior Mechanisms
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0848332 BXGD010879 Spots on skin Skin and Connective Tissue Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0857501 BXGD011152 Acute schizophrenia
C0859021 BXGD011201 Hyperthymic state
C0872084 BXGD011319 Sarcopenia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0947785 BXGD011495 [D]Sleep disturbances (& [hypersomnia] or [insomnia])
C1269955 BXGD012005 Tumor Cell Invasion
C1276071 BXGD012103 Childhood atopic dermatitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332629 BXGD012540 Breast Fibrocystic Change, Proliferative Type Skin and Connective Tissue Diseases
C1387532 BXGD012957 Chronic hemolytic anemia Hemic and Lymphatic Diseases
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1857640 BXGD015726 Decreased nerve conduction velocity
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1860808 BXGD016000 Triosephosphate Isomerase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C1962942 BXGD016677 TRICHOMONAS VAGINALIS (finding)
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347748 BXGD017041 Adult Erythroleukemia
C2718001 BXGD017521 Protein Misfolding Disorders Nutritional and Metabolic Diseases
C3277687 BXGD018717 Central nervous system degeneration
C3539781 BXGD019086 Progressive cGVHD
C3665488 BXGD019291 Familial Osteochondritis Dissecans Musculoskeletal Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806467 BXGD019513 Respiratory insufficiency due to muscle weakness Respiratory Tract Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4016412 BXGD020328 TRIOSEPHOSPHATE ISOMERASE MANCHESTER
C4023616 BXGD021229 Abnormality of immune system physiology
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4505386 BXGD022959 Giardia duodenalis Infection Digestive System Diseases; Infections
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4543807 BXGD023276 Clinical malaria Infections
C4551685 BXGD023390 Paralysis of diaphragm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
C4684880 BXGD023577 Advanced Bile Duct Carcinoma
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0001096 Dihydroxyacetone phosphate 170.06
BXGC0002591 Potassium 39.1
BXGC0002682 Zinc 65.41
BXGC0003757 2-Methylpropan-2-ol 74.12
BXGC0004266 2-Propanol 60.1
BXGC0010486 Ethyl brevifolincarboxylate 320.25
BXGC0035448 Methylbrevifolin Carboxylate 306.04
BXGC0051100 dihydroartemisinin 284.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein