Showing entry for Nociceptin receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010226
Protein NameNociceptin receptor
Uniport IdP41146
GeneOPRL1
Gene Id4987
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:1990708 conditioned place preference
Biological Process GO:0042755 eating behavior
Biological Process GO:0044849 estrous cycle
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0045776 negative regulation of blood pressure
Biological Process GO:1901386 negative regulation of voltage-gated calcium channel activity
Biological Process GO:0007218 neuropeptide signaling pathway
Biological Process GO:0038003 opioid receptor signaling pathway
Biological Process GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Biological Process GO:0060454 positive regulation of gastric acid secretion
Biological Process GO:1904058 positive regulation of sensory perception of pain
Biological Process GO:0035810 positive regulation of urine volume
Biological Process GO:1904059 regulation of locomotor rhythm
Biological Process GO:0032355 response to estradiol
Biological Process GO:0007600 sensory perception
Biological Process GO:0019233 sensory perception of pain
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0042923 neuropeptide binding
molecular function GO:0001626 nociceptin receptor activity
molecular function GO:0042277 peptide binding
molecular function GO:0008022 protein C-terminus binding
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020505 BXGD001412 Hyperphagia Pathological Conditions, Signs and Symptoms
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0026552 BXGD001906 Morphine Dependence Chemically-Induced Disorders; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038441 BXGD002756 Stress Disorders, Traumatic Mental Disorders
C0038587 BXGD002773 Substance Withdrawal Syndrome Chemically-Induced Disorders; Mental Disorders
C0042834 BXGD003004 Vital capacity
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085292 BXGD003153 Stiff-Person Syndrome Immune System Diseases; Nervous System Diseases
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0086189 BXGD003268 Drug Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0086439 BXGD003284 Hypokinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0149940 BXGD003391 Sciatic Neuropathy Nervous System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0205682 BXGD004105 Waist-Hip Ratio
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0242684 BXGD005188 Hypodynamia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0265987 BXGD005598 Nevus comedonicus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C0278080 BXGD006495 Physical addiction Chemically-Induced Disorders; Mental Disorders; Behavior and Behavior Mechanisms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0439053 BXGD008808 Fatigue - symptom Pathological Conditions, Signs and Symptoms
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524662 BXGD009238 Opiate Addiction Chemically-Induced Disorders; Mental Disorders
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0596887 BXGD009648 mathematical ability
C0600272 BXGD009702 Morphine Abuse Chemically-Induced Disorders; Mental Disorders
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0679272 BXGD009761 Polydrug abuse Chemically-Induced Disorders; Mental Disorders
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0745133 BXGD010118 Isolated systolic hypertension
C0751701 BXGD010558 Hypokinesia, Antiorthostatic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0857177 BXGD011141 Arthritic pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0871470 BXGD011316 Systolic Pressure
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1840061 BXGD014431 SMALL PATELLA SYNDROME Musculoskeletal Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0011725 (-)-Morphine 285.34
BXGC0041045 Buprenorphine 467.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein