Showing entry for Serine/threonine-protein kinase 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013307
Protein NameSerine/threonine-protein kinase 4
Uniport IdQ13043
GeneSTK4
Gene Id6789
DomainMst1_SARAH; Pkinase
Pfam PF11629   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05223 Non-small cell lung cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0001569 branching involved in blood vessel morphogenesis
Biological Process GO:0060706 cell differentiation involved in embryonic placenta development
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0007417 central nervous system development
Biological Process GO:0003157 endocardium development
Biological Process GO:0097284 hepatocyte apoptotic process
Biological Process GO:0035329 hippo signaling
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0046621 negative regulation of organ growth
Biological Process GO:0001841 neural tube formation
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0045600 positive regulation of fat cell differentiation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate
Biological Process GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
Biological Process GO:0060215 primitive hemopoiesis
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0050821 protein stabilization
Biological Process GO:0060800 regulation of cell differentiation involved in embryonic placenta development
Biological Process GO:0007165 signal transduction
Biological Process GO:0023014 signal transduction by protein phosphorylation
Biological Process GO:0031098 stress-activated protein kinase signaling cascade
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0043539 protein serine/threonine kinase activator activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0008134 transcription factor binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0016604 nuclear body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-2028269 Signaling by Hippo
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005587 BXGD000316 Depression, Bipolar Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024713 BXGD001799 Manic Disorder Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0043037 BXGD003023 Common wart Neoplasms; Infections; Skin and Connective Tissue Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236773 BXGD004827 Depressed bipolar I disorder Mental Disorders
C0242172 BXGD005138 Pelvic Inflammatory Disease Female Urogenital Diseases and Pregnancy Complications; Infections
C0242647 BXGD005184 Mucosa-Associated Lymphoid Tissue Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0338831 BXGD007216 Manic Mental Disorders
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0523465 BXGD009209 Serum albumin measurement
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1301034 BXGD012282 Pancreatic intraepithelial neoplasia Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1837066 BXGD014190 Recurrent viral infection Infections
C1840311 BXGD014445 Laryngeal cleft Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1844383 BXGD014628 Recurrent bacterial infection Infections
C1844384 BXGD014629 Recurrent fungal infections
C1850900 BXGD015186 Familial primary gastric lymphoma Digestive System Diseases; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2945759 BXGD018189 aggressive cancer
C2985280 BXGD018223 Blood Protein Measurement
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3553943 BXGD019196 T-CELL IMMUNODEFICIENCY, RECURRENT INFECTIONS, AND AUTOIMMUNITY WITH OR WITHOUT CARDIAC MALFORMATIONS
C3665596 BXGD019295 Warts Infections; Skin and Connective Tissue Diseases
C3887645 BXGD019910 Job Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C4016913 BXGD020389 T-CELL IMMUNODEFICIENCY, RECURRENT INFECTIONS, AUTOIMMUNITY, AND CARDIAC MALFORMATIONS
C4289709 BXGD022496 DOCK8 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000933 (-)-Arctigenin 372.41
BXGC0001940 Daphnetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0007052 Olomoucine 298.34
BXGC0012352 Chelerythrine 348.12
BXGC0012706 4-hydroxy-5-nitrophenyl acetic acid 197.03
BXGC0013582 Curcumin 368.13
BXGC0020911 Debromohymenialdisine 245.09
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0042870 Piceatannol 244.07
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein