Showing entry for Glycogen synthase kinase-3 alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010749
Protein NameGlycogen synthase kinase-3 alpha
Uniport IdP49840
GeneGSK3A
Gene Id2931
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04932 Non-alcoholic fatty liver disease (NAFLD)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0003214 cardiac left ventricle morphogenesis
Biological Process GO:0016477 cell migration
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0036016 cellular response to interleukin-3
Biological Process GO:0071285 cellular response to lithium ion
Biological Process GO:0007212 dopamine receptor signaling pathway
Biological Process GO:0060079 excitatory postsynaptic potential
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0005977 glycogen metabolic process
Biological Process GO:0044027 hypermethylation of CpG island
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:2000171 negative regulation of dendrite development
Biological Process GO:0046325 negative regulation of glucose import
Biological Process GO:2000466 negative regulation of glycogen (starch) synthase activity
Biological Process GO:0045719 negative regulation of glycogen biosynthetic process
Biological Process GO:1904227 negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
Biological Process GO:0046627 negative regulation of insulin receptor signaling pathway
Biological Process GO:0032007 negative regulation of TOR signaling
Biological Process GO:2000077 negative regulation of type B pancreatic cell development
Biological Process GO:0010905 negative regulation of UDP-glucose catabolic process
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0071879 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process GO:0106071 positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:0010508 positive regulation of autophagy
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:2000467 positive regulation of glycogen (starch) synthase activity
Biological Process GO:0045823 positive regulation of heart contraction
Biological Process GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0010800 positive regulation of peptidyl-threonine phosphorylation
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:1903955 positive regulation of protein targeting to mitochondrion
Biological Process GO:0031398 positive regulation of protein ubiquitination
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:1903146 regulation of autophagy of mitochondrion
Biological Process GO:0006349 regulation of gene expression by genetic imprinting
Biological Process GO:0010975 regulation of neuron projection development
Biological Process GO:0003073 regulation of systemic arterial blood pressure
Biological Process GO:0007165 signal transduction
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0034236 protein kinase A catalytic subunit binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0005102 signaling receptor binding
molecular function GO:0048156 tau protein binding
molecular function GO:0050321 tau-protein kinase activity
cellular component GO:0097440 apical dendrite
cellular component GO:0030424 axon
cellular component GO:0030877 beta-catenin destruction complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005874 microtubule
cellular component GO:0005739 mitochondrion
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
cellular component GO:0098794 postsynapse
cellular component GO:1990635 proximal dendrite
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9635465 Suppression of apoptosis
R-HSA-9635486 Infection with Mycobacterium tuberculosis
R-HSA-9637690 Response of Mtb to phagocytosis
R-HSA-9678108 SARS-CoV-1 Infection
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription
R-HSA-9682706 Replication of the SARS-CoV-1 genome
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription
R-HSA-9694686 Replication of the SARS-CoV-2 genome
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0004565 BXGD000276 Melanoma, B16 Neoplasms
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005587 BXGD000316 Depression, Bipolar Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0011573 BXGD000730 Endogenous depression Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024713 BXGD001799 Manic Disorder Mental Disorders
C0025193 BXGD001831 Melancholia Mental Disorders
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086133 BXGD003265 Depressive Syndrome Mental Disorders
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0282126 BXGD006796 Depression, Neurotic Mental Disorders
C0338831 BXGD007216 Manic Mental Disorders
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C4282128 BXGD022420 PATENT DUCTUS ARTERIOSUS 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000332 Fisetin 286.24
BXGC0000340 Kaempferol 286.24
BXGC0001545 Harmine 212.25
BXGC0002071 Apigenin 270.24
BXGC0002929 Hydantoin 100.08
BXGC0005683 Quercetin 302.24
BXGC0006635 Luteolin 286.24
BXGC0008167 Chrysin 254.24
BXGC0012352 Chelerythrine 348.12
BXGC0013109 4-[2-(3,5-Dihydroxyphenyl)Ethenyl]Benzene-1,2-Diol 244.07
BXGC0016599 4-Cyclopentene-1,3-Dione 96.02
BXGC0027547 Indigo 262.07
BXGC0028863 Atolaphyllidine 309.1
BXGC0040305 Indirubin 262.07
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0042701 Succinimide 99.03
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051398 Indole 117.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein