protein

Showing entry for Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)

General Target Information
BXGT Id	BXGT015894
Protein Name	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)
Uniport Id	Q5VZ30
Gene	GAD2
Gene Id	2572
Domain	Pyridoxal_deC
Pfam	PF00282
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.5 Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism
1. Metabolism	1.6 Metabolism of other amino acids	hsa00410	beta-Alanine metabolism
1. Metabolism	1.6 Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism
1. Metabolism	1.1 Carbohydrate metabolism	hsa00650	Butanoate metabolism
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways
5. Organismal Systems	5.6 Nervous system	hsa04727	GABAergic synapse
6. Human Diseases	6.7 Endocrine and metabolic diseases	hsa04940	Type I diabetes mellitus

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006540	glutamate decarboxylation to succinate
Biological Process	GO:0042493	response to drug
molecular function	GO:0016595	glutamate binding
molecular function	GO:0004351	glutamate decarboxylase activity
molecular function	GO:0044877	protein-containing complex binding
molecular function	GO:0030170	pyridoxal phosphate binding
cellular component	GO:0031225	anchored component of membrane
cellular component	GO:0030424	axon
cellular component	GO:0005829	cytosol
cellular component	GO:0060077	inhibitory synapse
cellular component	GO:0048471	perinuclear region of cytoplasm
cellular component	GO:0030672	synaptic vesicle membrane

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001403	BXGD000048	Addison Disease	Immune System Diseases; Endocrine System Diseases
C0001973	BXGD000095	Alcoholic Intoxication, Chronic	Chemically-Induced Disorders; Mental Disorders
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002622	BXGD000119	Amnesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002892	BXGD000149	Anemia, Pernicious	Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003469	BXGD000195	Anxiety Disorders	Mental Disorders
C0004352	BXGD000269	Autistic Disorder	Mental Disorders
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0005586	BXGD000315	Bipolar Disorder	Mental Disorders
C0005587	BXGD000316	Depression, Bipolar	Mental Disorders
C0006012	BXGD000360	Borderline Personality Disorder	Mental Disorders
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006287	BXGD000390	Bronchopulmonary Dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007570	BXGD000467	Celiac Disease	Digestive System Diseases; Nutritional and Metabolic Diseases
C0007682	BXGD000471	CNS disorder	Nervous System Diseases
C0007758	BXGD000475	Cerebellar Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009024	BXGD000578	Clonus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009171	BXGD000587	Cocaine Abuse	Chemically-Induced Disorders; Mental Disorders
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0010246	BXGD000656	Coxsackievirus Infections	Infections
C0010278	BXGD000660	Craniosynostosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011574	BXGD000731	Involutional Depression	Mental Disorders
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011880	BXGD000759	Diabetic Ketoacidosis	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884	BXGD000762	Diabetic Retinopathy	Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013363	BXGD000818	Dysautonomia	Nervous System Diseases
C0014038	BXGD000878	Encephalitis	Nervous System Diseases
C0014378	BXGD000912	Enterovirus Infections	Infections
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0014548	BXGD000928	Epilepsy, Generalized	Nervous System Diseases
C0014556	BXGD000932	Epilepsy, Temporal Lobe	Nervous System Diseases
C0015672	BXGD001011	Fatigue	Pathological Conditions, Signs and Symptoms
C0018213	BXGD001187	Graves Disease	Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018790	BXGD001221	Cardiac Arrest	Cardiovascular Diseases
C0019340	BXGD001321	Herpes NOS	Infections
C0019348	BXGD001325	Herpes Simplex Infections	Infections; Skin and Connective Tissue Diseases
C0020179	BXGD001363	Huntington Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020429	BXGD001378	Hyperalgesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0021670	BXGD001509	insulinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022333	BXGD001534	Jacksonian Seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022638	BXGD001567	Ketosis	Nutritional and Metabolic Diseases
C0022658	BXGD001570	Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024713	BXGD001799	Manic Disorder	Mental Disorders
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026837	BXGD001937	Muscle Rigidity	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026975	BXGD001954	Myelitis	Infections; Nervous System Diseases
C0027404	BXGD001984	Narcolepsy	Nervous System Diseases; Mental Disorders
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027765	BXGD002033	nervous system disorder	Nervous System Diseases
C0027796	BXGD002037	Neuralgia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027877	BXGD002055	Neuronal Ceroid-Lipofuscinoses	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756	BXGD002083	Obesity, Morbid	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028768	BXGD002084	Obsessive-Compulsive Disorder	Mental Disorders
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0030319	BXGD002208	Panic Disorder	Mental Disorders
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0033975	BXGD002447	Psychotic Disorders	Mental Disorders
C0035309	BXGD002530	Retinal Diseases	Eye Diseases
C0035921	BXGD002571	Congenital Rubella Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections
C0036337	BXGD002598	Schizoaffective Disorder	Mental Disorders
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037763	BXGD002699	Spasm	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040128	BXGD002844	Thyroid Diseases	Endocrine System Diseases
C0040156	BXGD002849	Thyrotoxicosis	Endocrine System Diseases
C0040264	BXGD002857	Tinnitus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0041696	BXGD002932	Unipolar Depression	Mental Disorders
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085271	BXGD003148	Self-Injurious Behavior	Behavior and Behavior Mechanisms
C0085292	BXGD003153	Stiff-Person Syndrome	Immune System Diseases; Nervous System Diseases
C0085543	BXGD003181	Epilepsia Partialis Continua	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086132	BXGD003264	Depressive Symptoms	Behavior and Behavior Mechanisms
C0149958	BXGD003395	Complex partial seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0150055	BXGD003401	Chronic pain	Pathological Conditions, Signs and Symptoms
C0162429	BXGD003942	Malnutrition	Nutritional and Metabolic Diseases
C0205734	BXGD004115	Diabetes, Autoimmune	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0221170	BXGD004400	Muscular stiffness	Nervous System Diseases
C0233514	BXGD004584	Abnormal behavior	Behavior and Behavior Mechanisms
C0234533	BXGD004687	Generalized seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535	BXGD004688	Clonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236736	BXGD004825	Cocaine-Related Disorders	Chemically-Induced Disorders; Mental Disorders
C0242422	BXGD005163	Parkinsonian Disorders	Nervous System Diseases
C0270549	BXGD006079	Generalized Anxiety Disorder	Mental Disorders
C0270824	BXGD006113	Visual seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844	BXGD006115	Tonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846	BXGD006116	Epileptic drop attack	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0271641	BXGD006225	Malnutrition related diabetes mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0338430	BXGD007173	Limbic Encephalitis	Neoplasms; Infections; Nervous System Diseases
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0338831	BXGD007216	Manic	Mental Disorders
C0338908	BXGD007218	Mixed anxiety and depressive disorder	Mental Disorders
C0342541	BXGD007499	Precocious pubarche	Endocrine System Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349204	BXGD007892	Nonorganic psychosis	Mental Disorders
C0362046	BXGD007959	Prediabetes syndrome	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0376338	BXGD007990	Diagnosis, Psychiatric	Mental Disorders
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0393591	BXGD008102	AICARDI-GOUTIERES SYNDROME	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Nervous System Diseases
C0393639	BXGD008110	Hashimoto's encephalitis	Nervous System Diseases; Endocrine System Diseases
C0422850	BXGD008457	Seizures, Somatosensory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852	BXGD008458	Seizures, Auditory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853	BXGD008459	Olfactory seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854	BXGD008460	Gustatory seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855	BXGD008461	Vertiginous seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424295	BXGD008524	Hyperactive behavior	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494475	BXGD009030	Tonic - clonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0525045	BXGD009255	Mood Disorders	Mental Disorders
C0563625	BXGD009484	Agnosia for Pain	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0600427	BXGD009706	Cocaine Dependence	Chemically-Induced Disorders; Mental Disorders
C0677607	BXGD009721	Hashimoto Disease	Endocrine System Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0740391	BXGD009987	Middle Cerebral Artery Occlusion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751056	BXGD010306	Non-epileptic convulsion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110	BXGD010318	Single Seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123	BXGD010326	Atonic Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214	BXGD010353	Hyperalgesia, Thermal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751295	BXGD010383	Memory Loss	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751383	BXGD010422	Juvenile Neuronal Ceroid Lipofuscinosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751494	BXGD010472	Convulsive Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495	BXGD010473	Seizures, Focal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496	BXGD010474	Seizures, Sensory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751791	BXGD010595	Reflex Epilepsy, Audiogenic	Nervous System Diseases
C0751950	BXGD010647	Neuromuscular Junction Diseases	Nervous System Diseases
C0795864	BXGD010754	Smith-Magenis syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0852733	BXGD010952	Completed Suicide
C0860603	BXGD011236	Anxiety symptoms
C1096063	BXGD011600	Drug Resistant Epilepsy	Nervous System Diseases
C1096184	BXGD011607	West Nile viral infection	Infections; Nervous System Diseases
C1112341	BXGD011664	Connective tissue inflammation
C1269683	BXGD012001	Major Depressive Disorder	Mental Disorders
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1328504	BXGD012469	Hormone refractory prostate cancer	Neoplasms; Male Urogenital Diseases
C1456399	BXGD013116	Crushing sensation
C1510586	BXGD013176	Autism Spectrum Disorders	Mental Disorders
C1533217	BXGD013313	Methamphetamine dependence	Chemically-Induced Disorders; Mental Disorders
C1571983	BXGD013425	Involutional paraphrenia	Mental Disorders
C1571984	BXGD013426	Psychosis, Involutional	Mental Disorders
C1611743	BXGD013456	Familial (FPAH)
C1739108	BXGD013730	Latent Autoimmune Diabetes in Adults	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C1840061	BXGD014431	SMALL PATELLA SYNDROME	Musculoskeletal Diseases
C1842981	BXGD014547	NEUROTICISM	Behavior and Behavior Mechanisms
C1861457	BXGD016052	PROGRESSIVE ENCEPHALOMYELITIS WITH RIGIDITY	Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases; Nervous System Diseases
C1960272	BXGD016654	Latent autoimmune diabetes mellitus in adult	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C2062441	BXGD016897	Influenza A
C2362324	BXGD017091	Pediatric Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2921125	BXGD017884	Post traumatic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2930824	BXGD017898	Autoimmune limbic encephalitis	Neoplasms; Infections; Immune System Diseases; Nervous System Diseases
C2936719	BXGD018130	Mechanical Allodynia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3250443	BXGD018584	MYOTONIC DYSTROPHY 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3495798	BXGD019003	Periodontal inflammation
C3495874	BXGD019008	Nonepileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3837958	BXGD019756	Diabetes Mellitus, Ketosis-Prone	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C4048158	BXGD021890	Convulsions	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4048329	BXGD021904	Immunosuppression
C4316903	BXGD022711	Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109	BXGD022725	Epileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123	BXGD022727	Myoclonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436	BXGD022962	Generalized Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4728082	BXGD023886	Severe hypoglycaemia

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0043088	Pyridoxal Phosphate		247.02

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}