Showing entry for Complications of Diabetes Mellitus


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD007447
Disease NameComplications of Diabetes Mellitus
Disease CUI IdC0342257
MeSH Codes C19  
Disease Class NameEndocrine System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15439 BXGT004169 Multidrug resistance-associated protein 4 10257 reviewed Transporter
O43451 BXGT004594 Maltase-glucoamylase, intestinal 8972 reviewed Enzyme
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 57016 reviewed Enzyme
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01275 BXGT005747 Glucagon 2641 reviewed
P01303 BXGT005748 Pro-neuropeptide Y 4852 reviewed Signaling
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02765 BXGT005952 Alpha-2-HS-glycoprotein 197 reviewed Enzyme modulator
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02774 BXGT005959 Vitamin D-binding protein 2638 reviewed Transporter
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04070 BXGT006143 Vitamin K-dependent protein C 5624 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase 2597 reviewed Enzyme
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05771 BXGT006384 Protein kinase C beta type 5579 reviewed Kinase
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P07203 BXGT006566 Glutathione peroxidase 1 2876 reviewed Enzyme
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08235 BXGT006751 Mineralocorticoid receptor 4306 reviewed Nuclear receptor
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08779 BXGT006824 Keratin, type I cytoskeletal 16 3868 reviewed
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10599 BXGT007583 Thioredoxin 7295 reviewed
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11597 BXGT007727 Cholesteryl ester transfer protein 1071 reviewed
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14410 BXGT008009 Sucrase-isomaltase, intestinal 6476 reviewed Enzyme
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 10327 reviewed Enzyme
P14672 BXGT008037 Solute carrier family 2, facilitated glucose transporter member 4 6517 reviewed Transporter
P14679 BXGT008039 Tyrosinase 7299 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 231 reviewed Enzyme
P15311 BXGT008106 Ezrin 7430 reviewed Cellular structure
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16050 BXGT008184 Arachidonate 15-lipoxygenase 246 reviewed Enzyme
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P17861 BXGT008348 X-box-binding protein 1 7494 reviewed
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P18075 BXGT008375 Bone morphogenetic protein 7 655 reviewed Signaling
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P18847 BXGT008431 Cyclic AMP-dependent transcription factor ATF-3 467 reviewed Transcription factor
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19634 BXGT008504 Sodium/hydrogen exchanger 1 6548 reviewed Transporter
P22413 BXGT008764 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 5167 reviewed Enzyme
P25116 BXGT009025 Proteinase-activated receptor 1 2149 reviewed G-protein coupled receptor
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P29466 BXGT009349 Caspase-1 834 reviewed Enzyme
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P31639 BXGT009556 Sodium/glucose cotransporter 2 6524 reviewed Transporter
P35414 BXGT009829 Apelin receptor 187 reviewed G-protein coupled receptor
P35557 BXGT009846 Glucokinase 2645 reviewed Kinase
P35613 BXGT009856 Basigin 682 reviewed
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 2324 reviewed Kinase
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P36969 BXGT009949 Phospholipid hydroperoxide glutathione peroxidase 2879 reviewed Enzyme
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P40933 BXGT010209 Interleukin-15 3600 reviewed
P41161 BXGT010229 ETS translocation variant 5 2119 reviewed Transcription factor
P41235 BXGT010241 Hepatocyte nuclear factor 4-alpha 3172 reviewed Nuclear receptor
P41252 BXGT010245 Isoleucine--tRNA ligase, cytoplasmic 3376 reviewed Enzyme
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43220 BXGT010367 Glucagon-like peptide 1 receptor 2740 reviewed G-protein coupled receptor
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48506 BXGT010635 Glutamate--cysteine ligase catalytic subunit 2729 reviewed Enzyme
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P51787 BXGT010889 Potassium voltage-gated channel subfamily KQT member 1 3784 reviewed Ion channel
P52594 BXGT010936 Arf-GAP domain and FG repeat-containing protein 1 3267 reviewed
P55211 BXGT011111 Caspase-9 842 reviewed Enzyme
P55789 BXGT011126 FAD-linked sulfhydryl oxidase ALR 2671 reviewed Enzyme
P81172 BXGT011935 Hepcidin 57817 reviewed
P98155 BXGT012226 Very low-density lipoprotein receptor 7436 reviewed
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q04760 BXGT012782 Lactoylglutathione lyase 2739 reviewed
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q09428 BXGT013036 ATP-binding cassette sub-family C member 8 6833 reviewed Transporter
Q12908 BXGT013278 Ileal sodium/bile acid cotransporter 6555 reviewed Transporter
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13164 BXGT013322 Mitogen-activated protein kinase 7 5598 reviewed Kinase
Q13546 BXGT013372 Receptor-interacting serine/threonine-protein kinase 1 8737 reviewed Kinase
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15582 BXGT013581 Transforming growth factor-beta-induced protein ig-h3 7045 reviewed Signaling
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q16853 BXGT013683 Membrane primary amine oxidase 8639 reviewed
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q86UW1 BXGT017613 Organic solute transporter subunit alpha 200931 reviewed Transporter
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 7442 reviewed Ion channel
Q8WTS6 BXGT018986 Histone-lysine N-methyltransferase SETD7 80854 reviewed Epigenetic regulator
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q99757 BXGT019959 Thioredoxin, mitochondrial 25828 reviewed Enzyme
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO 79068 reviewed
Q9H3M7 BXGT020462 Thioredoxin-interacting protein 10628 reviewed
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9UGB7 BXGT021678 Inositol oxygenase 55586 reviewed Enzyme
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y4B6 BXGT022272 DDB1- and CUL4-associated factor 1 9730 reviewed
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
O60502 BXGT023392 Protein O-GlcNAcase 10724 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P56703 BXGT023722 Proto-oncogene Wnt-3 7473 reviewed Signaling
Q96A54 BXGT024681 Adiponectin receptor protein 1 51094 reviewed Receptor
Q9BY76 BXGT025687 Angiopoietin-related protein 4 51129 reviewed Signaling
P35250 BXGT025854 Replication factor C subunit 2 5982 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease