Showing entry for Phospholipid hydroperoxide glutathione peroxidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009949
Protein NamePhospholipid hydroperoxide glutathione peroxidase
Uniport IdP36969
GeneGPX4
Gene Id2879
DomainGSHPx
Pfam PF00255  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.6 Metabolism of other amino acids hsa00480 Glutathione metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006749 glutathione metabolic process
Biological Process GO:0019372 lipoxygenase pathway
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0110076 negative regulation of ferroptosis
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:0051258 protein polymerization
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0032355 response to estradiol
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0007283 spermatogenesis
molecular function GO:0004602 glutathione peroxidase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0004601 peroxidase activity
molecular function GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity
molecular function GO:0008430 selenium binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005739 mitochondrion
cellular component GO:0005635 nuclear envelope
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-556833 Metabolism of lipids
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001857 BXGD000085 AIDS related complex Infections; Immune System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006635 BXGD000402 Cadmium poisoning Chemically-Induced Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007117 BXGD000433 Basal cell carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0012684 BXGD000781 Blastocyst Disintegration Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0013937 BXGD000871 Embryo Resorption Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0016059 BXGD001043 Fibrosis Pathological Conditions, Signs and Symptoms
C0017638 BXGD001132 Glioma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030044 BXGD002186 Acrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036646 BXGD002627 Age-related cataract Eye Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042875 BXGD003009 Vitamin E Deficiency Nutritional and Metabolic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0151860 BXGD003490 Acquired porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0206710 BXGD004258 Basal Cell Neoplasm Neoplasms
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238421 BXGD004928 Selenium deficiency
C0239594 BXGD004987 Short finger
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0259749 BXGD005216 Autonomic neuropathy Nervous System Diseases
C0262405 BXGD005237 Cerebral dysfunction Nervous System Diseases
C0265290 BXGD005503 Metaphyseal chondrodysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0266483 BXGD005680 Pachygyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339352 BXGD007243 Capsular cataract (disorder) Eye Diseases
C0342257 BXGD007447 Complications of Diabetes Mellitus Endocrine System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410179 BXGD008411 Ullrich congenital muscular dystrophy 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0426790 BXGD008577 Narrow thorax
C0426817 BXGD008585 Short ribs
C0431478 BXGD008692 Posteriorly rotated ear
C0431663 BXGD008700 Bilateral Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0431664 BXGD008701 Unilateral Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0451817 BXGD008827 Dietary selenium deficiency
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0521525 BXGD009139 Short neck
C0541764 BXGD009259 Delayed bone age
C0545053 BXGD009323 Advanced bone age
C0566888 BXGD009493 Narrow sacrosciatic notch
C0581342 BXGD009560 Redundant skin Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600228 BXGD009699 Cardiopulmonary Arrest Cardiovascular Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699893 BXGD009871 Skin carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700635 BXGD009897 Strudwick syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751676 BXGD010549 Basal Cell Cancer Neoplasms
C0752350 BXGD010722 Embryo Death Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0752351 BXGD010723 Embryo Loss Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0848676 BXGD010883 Subfertility, Male Male Urogenital Diseases
C0877165 BXGD011338 Short phalanx of finger
C0917731 BXGD011407 Male sterility Male Urogenital Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1136082 BXGD011707 Embryo Disintegration Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1176475 BXGD011798 Ductal Carcinoma Neoplasms
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1563730 BXGD013394 Abdominal Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C1563731 BXGD013395 Inguinal Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1740787 BXGD013742 Cardiac autonomic neuropathy Nervous System Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1836195 BXGD014094 Short toe
C1836542 BXGD014129 Depressed nasal bridge
C1837082 BXGD014194 Metaphyseal cupping
C1837084 BXGD014195 Short metacarpal
C1837485 BXGD014239 Flat acetabular roof
C1838662 BXGD014334 Metaphyseal irregularity
C1839731 BXGD014397 11 pairs of ribs
C1842083 BXGD014494 Abnormality of the ribs
C1843108 BXGD014556 Short palm
C1844548 BXGD014642 Hypoplastic finger
C1844704 BXGD014665 Platyspondyly
C1848109 BXGD014906 Long fibula
C1854912 BXGD015441 Short long bone
C1855229 BXGD015474 Spondylometaphyseal dysplasia, Sedaghatian type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1855230 BXGD015475 Focal lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1855233 BXGD015476 Large posterior fontanelle
C1855239 BXGD015477 Cone-shaped metacarpal epiphyses
C1855240 BXGD015478 Irregular tarsal bones
C1857186 BXGD015683 Iliac crest serration
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859480 BXGD015899 Cone-shaped epiphyses of the phalanges of the hand
C1865037 BXGD016289 Cone-shaped epiphysis
C1865039 BXGD016291 Cupped ribs
C1865200 BXGD016298 Delayed epiphyseal ossification
C1865841 BXGD016343 Flared iliac wings
C1866730 BXGD016419 Rhizomelia
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C1969532 BXGD016779 Rhizomelic arm shortening
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2745963 BXGD017571 Kashin-Beck Disease Musculoskeletal Diseases
C3164407 BXGD018528 Oligoasthenozoospermia
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C3806511 BXGD019516 Horizontal inferior border of scapula
C3840565 BXGD019797 Autoimmune thyroid disease (AITD)
C3854173 BXGD019824 Pre-renal acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4020732 BXGD020474 Mitochondrial abnormalities
C4024620 BXGD021348 Widened sacrosciatic notch
C4025828 BXGD021815 Abnormality of the scapula
C4082172 BXGD022086 Porencephalic cyst
C4285807 BXGD022455 Behavioral and psychological symptoms of dementia
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000989 Glutathione 307.32
BXGC0003705 Chloride 35.45
BXGC0035443 L-Cysteic acid 169
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein