Showing entry for Sodium/hydrogen exchanger 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008504
Protein NameSodium/hydrogen exchanger 1
Uniport IdP19634
GeneSLC9A1
Gene Id6548
DomainNa_H_Exchanger; NEXCaM_BD
Pfam PF00999   PF16644  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086003 cardiac muscle cell contraction
Biological Process GO:0055007 cardiac muscle cell differentiation
Biological Process GO:0016477 cell migration
Biological Process GO:0071468 cellular response to acidic pH
Biological Process GO:0071236 cellular response to antibiotic
Biological Process GO:0070417 cellular response to cold
Biological Process GO:0071257 cellular response to electrical stimulus
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0006883 cellular sodium ion homeostasis
Biological Process GO:0030214 hyaluronan catabolic process
Biological Process GO:0006811 ion transport
Biological Process GO:0030011 maintenance of cell polarity
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0070997 neuron death
Biological Process GO:0045760 positive regulation of action potential
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
Biological Process GO:1903281 positive regulation of calcium:sodium antiporter activity
Biological Process GO:0010613 positive regulation of cardiac muscle hypertrophy
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0035794 positive regulation of mitochondrial membrane permeability
Biological Process GO:0098735 positive regulation of the force of heart contraction
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0051259 protein complex oligomerization
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:0086036 regulation of cardiac muscle cell membrane potential
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0051893 regulation of focal adhesion assembly
Biological Process GO:0051453 regulation of intracellular pH
Biological Process GO:0006885 regulation of pH
Biological Process GO:0051930 regulation of sensory perception of pain
Biological Process GO:0051492 regulation of stress fiber assembly
Biological Process GO:0086092 regulation of the force of heart contraction by cardiac conduction
Biological Process GO:0010447 response to acidic pH
Biological Process GO:0035994 response to muscle stretch
Biological Process GO:0036376 sodium ion export across plasma membrane
Biological Process GO:0098719 sodium ion import across plasma membrane
molecular function GO:0048306 calcium-dependent protein binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0060090 molecular adaptor activity
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
molecular function GO:0015386 potassium:proton antiporter activity
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0030346 protein phosphatase 2B binding
molecular function GO:0015385 sodium:proton antiporter activity
molecular function GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
molecular function GO:0015299 solute:proton antiporter activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0090533 cation-transporting ATPase complex
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0014704 intercalated disc
cellular component GO:0030027 lamellipodium
cellular component GO:0045121 membrane raft
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0030315 T-tubule
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-2142845 Hyaluronan metabolism
R-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-382551 Transport of small molecules
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-425986 Sodium/Proton exchangers
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002152 BXGD000104 Alloxan Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009917 BXGD000635 Contracture Musculoskeletal Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010709 BXGD000689 Cyst Pathological Conditions, Signs and Symptoms; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018834 BXGD001238 Heartburn Pathological Conditions, Signs and Symptoms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020488 BXGD001402 Hypernatremia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020545 BXGD001427 Hypertension, Renovascular Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022116 BXGD001531 Ischemia Pathological Conditions, Signs and Symptoms
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0029531 BXGD002164 Other cataract Eye Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032969 BXGD002385 Pregnancy in Diabetics Female Urogenital Diseases and Pregnancy Complications
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036982 BXGD002651 Shock, Hemorrhagic Pathological Conditions, Signs and Symptoms
C0038433 BXGD002754 Streptozotocin Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151603 BXGD003445 Anasarca Pathological Conditions, Signs and Symptoms
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162770 BXGD003980 Right Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202236 BXGD004086 Triglycerides measurement
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0234162 BXGD004627 Cerebellar Dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234230 BXGD004635 Pain, Burning Pathological Conditions, Signs and Symptoms
C0234238 BXGD004637 Ache Pathological Conditions, Signs and Symptoms
C0234254 BXGD004648 Radiating pain Pathological Conditions, Signs and Symptoms
C0234376 BXGD004659 Action Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234979 BXGD004707 Dysdiadochokinesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0267663 BXGD005765 Congenital secretory diarrhea, sodium type (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279070 BXGD006625 Adult Oligodendroglioma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280232 BXGD006724 stage, cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280475 BXGD006749 Childhood Oligodendroglioma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333641 BXGD006961 Atrophic Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342257 BXGD007447 Complications of Diabetes Mellitus Endocrine System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0458257 BXGD008905 Pain, Splitting Pathological Conditions, Signs and Symptoms
C0458259 BXGD008906 Pain, Crushing Pathological Conditions, Signs and Symptoms
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600519 BXGD009712 Ventricular Remodeling Pathological Conditions, Signs and Symptoms
C0600520 BXGD009713 Left Ventricle Remodeling Pathological Conditions, Signs and Symptoms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0751407 BXGD010429 Pain, Migratory Pathological Conditions, Signs and Symptoms
C0751408 BXGD010430 Suffering, Physical Pathological Conditions, Signs and Symptoms
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752308 BXGD010715 Hypoxia-Ischemia, Brain Nervous System Diseases; Cardiovascular Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1258085 BXGD011822 Barrett Epithelium Digestive System Diseases; Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1854301 BXGD015391 Motor delay Mental Disorders
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4225383 BXGD022255 LICHTENSTEIN-KNORR SYNDROME
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004275 Acetaldehyde 44.05
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein