Showing entry for Vitamin K epoxide reductase complex subunit 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020108
Protein NameVitamin K epoxide reductase complex subunit 1
Uniport IdQ9BQB6
GeneVKORC1
Gene Id79001
DomainVKOR
Pfam PF07884  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0060348 bone development
Biological Process GO:0017144 drug metabolic process
Biological Process GO:0017187 peptidyl-glutamic acid carboxylation
Biological Process GO:0030193 regulation of blood coagulation
Biological Process GO:0046677 response to antibiotic
Biological Process GO:0014070 response to organic cyclic compound
Biological Process GO:0010243 response to organonitrogen compound
Biological Process GO:0042373 vitamin K metabolic process
molecular function GO:0048038 quinone binding
molecular function GO:0047058 vitamin-K-epoxide reductase (warfarin-insensitive) activity
molecular function GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-6806664 Metabolism of vitamin K
R-HSA-6806667 Metabolism of fat-soluble vitamins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003496 BXGD000200 Aortic Rupture Cardiovascular Diseases; Wounds and Injuries
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018824 BXGD001237 Heart valve disease Cardiovascular Diseases
C0019080 BXGD001279 Hemorrhage Pathological Conditions, Signs and Symptoms
C0019087 BXGD001280 Hemorrhagic Disorders Hemic and Lymphatic Diseases
C0019154 BXGD001291 Hepatic Vein Thrombosis Digestive System Diseases; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027149 BXGD001979 Myxoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029458 BXGD002158 Osteoporosis, Postmenopausal Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033847 BXGD002437 Pseudoxanthoma Elasticum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0035328 BXGD002537 Retinal Vein Occlusion Eye Diseases; Cardiovascular Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042880 BXGD003011 Vitamin K Deficiency Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0087086 BXGD003320 Thrombus Cardiovascular Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0272315 BXGD006341 Coagulation factor deficiency syndrome Hemic and Lymphatic Diseases
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0342143 BXGD007435 Hyperthyroidism secondary to amiodarone Endocrine System Diseases
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0424621 BXGD008536 Body Fat Distribution
C0584960 BXGD009579 Factor V Leiden mutation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0741160 BXGD010025 Aortic Aneurysm, Ruptured Cardiovascular Diseases; Wounds and Injuries
C0750384 BXGD010234 Coumarin Resistance Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0850715 BXGD010907 Abnormality of blood and blood-forming tissues
C0852949 BXGD010957 Arteriopathic disease Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0856761 BXGD011115 Budd-Chiari Syndrome Digestive System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1096249 BXGD011612 Calcification of the aorta
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1709735 BXGD013631 Prosthetic Valve Thrombosis Cardiovascular Diseases
C1843832 BXGD014610 VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1848534 BXGD014937 VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1862382 BXGD016125 SVEINSSON CHORIORETINAL ATROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1865343 BXGD016316 OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT OF SPINE Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2608079 BXGD017154 WARFARIN SENSITIVITY (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2675747 BXGD017308 Coumarin Sensitivity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2718087 BXGD017527 Vitamin K Deficiency Bleeding Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3888513 BXGD019975 CYP2C9 polymorphism
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4023159 BXGD021128 Reduced factor IX activity
C4024702 BXGD021377 Reduced factor X activity
C4024722 BXGD021385 Reduced factor VII activity
C4076240 BXGD022073 Chronic kidney disease mineral and bone disorder Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Endocrine System Diseases
C4280698 BXGD022385 Reduced prothrombin antigen
C4476767 BXGD022864 Diffuse alveolar hemorrhage
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006156 Dicoumarol 336.3
BXGC0040042 Warfarin 308.1
BXGC0044200 Menadione 172.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein